Lung function decline is associated with serum uric acid in Korean health screening individuals

Abstract We performed a retrospective cohort study of 19,237 individuals who underwent at least three health screenings with follow-up periods of over 5 years to find a routinely checked serum marker that predicts lung function decline. Using linear regression models to analyze associations between...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kyung-Min Ahn, Suh-Young Lee, So-Hee Lee, Sun-Sin Kim, Heung-Woo Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8485de8cb5784d65a240bafcd0c54d1f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8485de8cb5784d65a240bafcd0c54d1f
record_format	dspace
spelling	oai:doaj.org-article:8485de8cb5784d65a240bafcd0c54d1f2021-12-02T15:42:59ZLung function decline is associated with serum uric acid in Korean health screening individuals10.1038/s41598-021-89678-32045-2322https://doaj.org/article/8485de8cb5784d65a240bafcd0c54d1f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89678-3https://doaj.org/toc/2045-2322Abstract We performed a retrospective cohort study of 19,237 individuals who underwent at least three health screenings with follow-up periods of over 5 years to find a routinely checked serum marker that predicts lung function decline. Using linear regression models to analyze associations between the rate of decline in the forced expiratory volume in 1 s (FEV1) and the level of 10 serum markers (calcium, phosphorus, uric acid, total cholesterol, total protein, total bilirubin, alkaline phosphatase, aspartate aminotransferase, creatinine, and C-reactive protein) measured at two different times (at the first and third health screenings), we found that an increased uric acid level was significantly associated with an accelerated FEV1 decline (P = 0.0014 and P = 0.037, respectively) and reduced FEV1 predicted % (P = 0.0074 and P = 8.64 × 10–7, respectively) at both visits only in non-smoking individuals. In addition, we confirmed that accelerated forced vital capacity (FVC) and FEV1/FVC ratio declines were observed in non-smoking individuals with increased serum uric acid levels using linear mixed models. The serum uric acid level thus potentially predicts an acceleration in lung function decline in a non-smoking general population.Kyung-Min AhnSuh-Young LeeSo-Hee LeeSun-Sin KimHeung-Woo ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyung-Min Ahn Suh-Young Lee So-Hee Lee Sun-Sin Kim Heung-Woo Park Lung function decline is associated with serum uric acid in Korean health screening individuals
description	Abstract We performed a retrospective cohort study of 19,237 individuals who underwent at least three health screenings with follow-up periods of over 5 years to find a routinely checked serum marker that predicts lung function decline. Using linear regression models to analyze associations between the rate of decline in the forced expiratory volume in 1 s (FEV1) and the level of 10 serum markers (calcium, phosphorus, uric acid, total cholesterol, total protein, total bilirubin, alkaline phosphatase, aspartate aminotransferase, creatinine, and C-reactive protein) measured at two different times (at the first and third health screenings), we found that an increased uric acid level was significantly associated with an accelerated FEV1 decline (P = 0.0014 and P = 0.037, respectively) and reduced FEV1 predicted % (P = 0.0074 and P = 8.64 × 10–7, respectively) at both visits only in non-smoking individuals. In addition, we confirmed that accelerated forced vital capacity (FVC) and FEV1/FVC ratio declines were observed in non-smoking individuals with increased serum uric acid levels using linear mixed models. The serum uric acid level thus potentially predicts an acceleration in lung function decline in a non-smoking general population.
format	article
author	Kyung-Min Ahn Suh-Young Lee So-Hee Lee Sun-Sin Kim Heung-Woo Park
author_facet	Kyung-Min Ahn Suh-Young Lee So-Hee Lee Sun-Sin Kim Heung-Woo Park
author_sort	Kyung-Min Ahn
title	Lung function decline is associated with serum uric acid in Korean health screening individuals
title_short	Lung function decline is associated with serum uric acid in Korean health screening individuals
title_full	Lung function decline is associated with serum uric acid in Korean health screening individuals
title_fullStr	Lung function decline is associated with serum uric acid in Korean health screening individuals
title_full_unstemmed	Lung function decline is associated with serum uric acid in Korean health screening individuals
title_sort	lung function decline is associated with serum uric acid in korean health screening individuals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8485de8cb5784d65a240bafcd0c54d1f
work_keys_str_mv	AT kyungminahn lungfunctiondeclineisassociatedwithserumuricacidinkoreanhealthscreeningindividuals AT suhyounglee lungfunctiondeclineisassociatedwithserumuricacidinkoreanhealthscreeningindividuals AT soheelee lungfunctiondeclineisassociatedwithserumuricacidinkoreanhealthscreeningindividuals AT sunsinkim lungfunctiondeclineisassociatedwithserumuricacidinkoreanhealthscreeningindividuals AT heungwoopark lungfunctiondeclineisassociatedwithserumuricacidinkoreanhealthscreeningindividuals
_version_	1718385817161826304

Lung function decline is associated with serum uric acid in Korean health screening individuals

Ejemplares similares