Liver fat scores do not reflect interventional changes in liver fat content induced by high-protein diets

Abstract Non-alcoholic fatty liver disease (NAFLD) is common in Metabolic Syndrome and type 2 diabetes (T2DM), driven by energy imbalance, saturated fats and simple carbohydrates. NAFLD requires screening and monitoring for late complications. Liver fat indices may predict NAFLD avoiding expensive o...

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Autores principales:	Stefan Kabisch, Mariya Markova, Silke Hornemann, Stephanie Sucher, Olga Pivovarova-Ramich, Jürgen Machann, Johannes Hierholzer, Sascha Rohn, Andreas F. H. Pfeiffer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8487ee657cc844dfa87948c21f423a06
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spelling	oai:doaj.org-article:8487ee657cc844dfa87948c21f423a062021-12-02T15:27:12ZLiver fat scores do not reflect interventional changes in liver fat content induced by high-protein diets10.1038/s41598-021-87360-22045-2322https://doaj.org/article/8487ee657cc844dfa87948c21f423a062021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87360-2https://doaj.org/toc/2045-2322Abstract Non-alcoholic fatty liver disease (NAFLD) is common in Metabolic Syndrome and type 2 diabetes (T2DM), driven by energy imbalance, saturated fats and simple carbohydrates. NAFLD requires screening and monitoring for late complications. Liver fat indices may predict NAFLD avoiding expensive or invasive gold-standard methods, but they are poorly validated for use in interventional settings. Recent data indicate a particular insensitivity to weight-independent liver fat reduction. We evaluated 31 T2DM patients, completing a randomized intervention study on isocaloric high-protein diets. We assessed anthropometric measures, intrahepatic lipid (IHL) content and serum liver enzymes, allowing AUROC calculations as well as cross-sectional and longitudinal Spearman correlations between the fatty liver index, the NAFLD-liver fat score, the Hepatosteatosis Index, and IHL. At baseline, all indices predicted NAFLD with moderate accuracy (AUROC 0.731–0.770), supported by correlation analyses. Diet-induced IHL changes weakly correlated with changes of waist circumference, but no other index component or the indices themselves. Liver fat indices may help to easily detect NAFLD, allowing cost-effective allocation of further diagnostics to patients at high risk. IHL reduction by weight-independent diets is not reflected by a proportional change in liver fat scores. Further research on the development of treatment-sensitive indices is required. Trial registration: The trial was registered at clinicaltrials.gov: NCT02402985.Stefan KabischMariya MarkovaSilke HornemannStephanie SucherOlga Pivovarova-RamichJürgen MachannJohannes HierholzerSascha RohnAndreas F. H. PfeifferNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefan Kabisch Mariya Markova Silke Hornemann Stephanie Sucher Olga Pivovarova-Ramich Jürgen Machann Johannes Hierholzer Sascha Rohn Andreas F. H. Pfeiffer Liver fat scores do not reflect interventional changes in liver fat content induced by high-protein diets
description	Abstract Non-alcoholic fatty liver disease (NAFLD) is common in Metabolic Syndrome and type 2 diabetes (T2DM), driven by energy imbalance, saturated fats and simple carbohydrates. NAFLD requires screening and monitoring for late complications. Liver fat indices may predict NAFLD avoiding expensive or invasive gold-standard methods, but they are poorly validated for use in interventional settings. Recent data indicate a particular insensitivity to weight-independent liver fat reduction. We evaluated 31 T2DM patients, completing a randomized intervention study on isocaloric high-protein diets. We assessed anthropometric measures, intrahepatic lipid (IHL) content and serum liver enzymes, allowing AUROC calculations as well as cross-sectional and longitudinal Spearman correlations between the fatty liver index, the NAFLD-liver fat score, the Hepatosteatosis Index, and IHL. At baseline, all indices predicted NAFLD with moderate accuracy (AUROC 0.731–0.770), supported by correlation analyses. Diet-induced IHL changes weakly correlated with changes of waist circumference, but no other index component or the indices themselves. Liver fat indices may help to easily detect NAFLD, allowing cost-effective allocation of further diagnostics to patients at high risk. IHL reduction by weight-independent diets is not reflected by a proportional change in liver fat scores. Further research on the development of treatment-sensitive indices is required. Trial registration: The trial was registered at clinicaltrials.gov: NCT02402985.
format	article
author	Stefan Kabisch Mariya Markova Silke Hornemann Stephanie Sucher Olga Pivovarova-Ramich Jürgen Machann Johannes Hierholzer Sascha Rohn Andreas F. H. Pfeiffer
author_facet	Stefan Kabisch Mariya Markova Silke Hornemann Stephanie Sucher Olga Pivovarova-Ramich Jürgen Machann Johannes Hierholzer Sascha Rohn Andreas F. H. Pfeiffer
author_sort	Stefan Kabisch
title	Liver fat scores do not reflect interventional changes in liver fat content induced by high-protein diets
title_short	Liver fat scores do not reflect interventional changes in liver fat content induced by high-protein diets
title_full	Liver fat scores do not reflect interventional changes in liver fat content induced by high-protein diets
title_fullStr	Liver fat scores do not reflect interventional changes in liver fat content induced by high-protein diets
title_full_unstemmed	Liver fat scores do not reflect interventional changes in liver fat content induced by high-protein diets
title_sort	liver fat scores do not reflect interventional changes in liver fat content induced by high-protein diets
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8487ee657cc844dfa87948c21f423a06
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Liver fat scores do not reflect interventional changes in liver fat content induced by high-protein diets

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