Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells

Abstract In response to UV irradiation, translesion DNA synthesis (TLS) utilizes specialized DNA polymerases to bypass replication-blocking lesions. In a well-established polymerase switch model, Polη is thought to be a preferred TLS polymerase to insert correct nucleotides across from the thymine d...

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Autores principales: Tonghui Bi, Xiaohong Niu, Chunping Qin, Wei Xiao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/84893909b2c14fa98bd3f2f0eb8fa9cd
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