Cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study.

<h4>Aims</h4>Metabolic disturbances may contribute to cognitive dysfunction in patients with type 2 diabetes. We investigated the relation between cognitive impairment and metabolic deteriorations, low physical fitness, low-grade inflammation and abdominal obesity in middle aged individu...

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Autores principales: Maria Pedersen, Karin Kaereby Pedersen, Helle Bruunsgaard, Karen Suarez Krabbe, Carsten Thomsen, Kristine Færch, Bente Klarlund Pedersen, Erik Lykke Mortensen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/848d3ec2b5244024b7c94a7fb1548a6e
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Sumario:<h4>Aims</h4>Metabolic disturbances may contribute to cognitive dysfunction in patients with type 2 diabetes. We investigated the relation between cognitive impairment and metabolic deteriorations, low physical fitness, low-grade inflammation and abdominal obesity in middle aged individuals.<h4>Methods</h4>We conducted a cross-sectional study including 40 to 65 year-old patients with type 2 diabetes and limited co morbidity (N = 56), age-matched individuals with impaired glucose tolerance (N = 56) as well as age-matched controls with normal glucose tolerance (N = 72). Specific cognitive functions were assessed with focus on verbal memory, processing speed, executive functions, and a composite overall mean score. Oral glucose tolerance test, VO(2)max test, systemic inflammation, DXA scanning and abdominal MRI were measured.<h4>Results</h4>Multiple linear regression analyses adjusting for age, gender and verbal intelligence demonstrated that a low score in processing speed, executive functions and overall cognitive function were related to high fasting C-peptide, as well as low insulin sensitivity, beta-cell function and VO(2)max. Measurements of blood glucose, obesity and inflammation were not associated with cognitive function.<h4>Conclusion</h4>Low cognitive scores are seen in middle aged individuals with hyperinsulinemia, low insulin sensitivity, beta-cell function and low aerobic capacity. These findings emphasize the importance of appropriate lifestyle and not only blood glucose control in prevention of cognitive disability.