Cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study.

<h4>Aims</h4>Metabolic disturbances may contribute to cognitive dysfunction in patients with type 2 diabetes. We investigated the relation between cognitive impairment and metabolic deteriorations, low physical fitness, low-grade inflammation and abdominal obesity in middle aged individu...

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Autores principales:	Maria Pedersen, Karin Kaereby Pedersen, Helle Bruunsgaard, Karen Suarez Krabbe, Carsten Thomsen, Kristine Færch, Bente Klarlund Pedersen, Erik Lykke Mortensen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/848d3ec2b5244024b7c94a7fb1548a6e
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spelling	oai:doaj.org-article:848d3ec2b5244024b7c94a7fb1548a6e2021-11-18T08:05:25ZCognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study.1932-620310.1371/journal.pone.0051132https://doaj.org/article/848d3ec2b5244024b7c94a7fb1548a6e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23251434/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aims</h4>Metabolic disturbances may contribute to cognitive dysfunction in patients with type 2 diabetes. We investigated the relation between cognitive impairment and metabolic deteriorations, low physical fitness, low-grade inflammation and abdominal obesity in middle aged individuals.<h4>Methods</h4>We conducted a cross-sectional study including 40 to 65 year-old patients with type 2 diabetes and limited co morbidity (N = 56), age-matched individuals with impaired glucose tolerance (N = 56) as well as age-matched controls with normal glucose tolerance (N = 72). Specific cognitive functions were assessed with focus on verbal memory, processing speed, executive functions, and a composite overall mean score. Oral glucose tolerance test, VO(2)max test, systemic inflammation, DXA scanning and abdominal MRI were measured.<h4>Results</h4>Multiple linear regression analyses adjusting for age, gender and verbal intelligence demonstrated that a low score in processing speed, executive functions and overall cognitive function were related to high fasting C-peptide, as well as low insulin sensitivity, beta-cell function and VO(2)max. Measurements of blood glucose, obesity and inflammation were not associated with cognitive function.<h4>Conclusion</h4>Low cognitive scores are seen in middle aged individuals with hyperinsulinemia, low insulin sensitivity, beta-cell function and low aerobic capacity. These findings emphasize the importance of appropriate lifestyle and not only blood glucose control in prevention of cognitive disability.Maria PedersenKarin Kaereby PedersenHelle BruunsgaardKaren Suarez KrabbeCarsten ThomsenKristine FærchBente Klarlund PedersenErik Lykke MortensenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51132 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Pedersen Karin Kaereby Pedersen Helle Bruunsgaard Karen Suarez Krabbe Carsten Thomsen Kristine Færch Bente Klarlund Pedersen Erik Lykke Mortensen Cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study.
description	<h4>Aims</h4>Metabolic disturbances may contribute to cognitive dysfunction in patients with type 2 diabetes. We investigated the relation between cognitive impairment and metabolic deteriorations, low physical fitness, low-grade inflammation and abdominal obesity in middle aged individuals.<h4>Methods</h4>We conducted a cross-sectional study including 40 to 65 year-old patients with type 2 diabetes and limited co morbidity (N = 56), age-matched individuals with impaired glucose tolerance (N = 56) as well as age-matched controls with normal glucose tolerance (N = 72). Specific cognitive functions were assessed with focus on verbal memory, processing speed, executive functions, and a composite overall mean score. Oral glucose tolerance test, VO(2)max test, systemic inflammation, DXA scanning and abdominal MRI were measured.<h4>Results</h4>Multiple linear regression analyses adjusting for age, gender and verbal intelligence demonstrated that a low score in processing speed, executive functions and overall cognitive function were related to high fasting C-peptide, as well as low insulin sensitivity, beta-cell function and VO(2)max. Measurements of blood glucose, obesity and inflammation were not associated with cognitive function.<h4>Conclusion</h4>Low cognitive scores are seen in middle aged individuals with hyperinsulinemia, low insulin sensitivity, beta-cell function and low aerobic capacity. These findings emphasize the importance of appropriate lifestyle and not only blood glucose control in prevention of cognitive disability.
format	article
author	Maria Pedersen Karin Kaereby Pedersen Helle Bruunsgaard Karen Suarez Krabbe Carsten Thomsen Kristine Færch Bente Klarlund Pedersen Erik Lykke Mortensen
author_facet	Maria Pedersen Karin Kaereby Pedersen Helle Bruunsgaard Karen Suarez Krabbe Carsten Thomsen Kristine Færch Bente Klarlund Pedersen Erik Lykke Mortensen
author_sort	Maria Pedersen
title	Cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study.
title_short	Cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study.
title_full	Cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study.
title_fullStr	Cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study.
title_full_unstemmed	Cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study.
title_sort	cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/848d3ec2b5244024b7c94a7fb1548a6e
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Cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study.

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