CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation

Chromatin remodellers hydrolyse ATP to move nucleosomal DNA against histone octamers. Here, the authors use single-molecule assays to examine the mechanism of action of CHD4 remodeller, and provide evidence that CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation.

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Autores principales:	Yichen Zhong, Bishnu P. Paudel, Daniel P. Ryan, Jason K. K. Low, Charlotte Franck, Karishma Patel, Max J. Bedward, Mario Torrado, Richard J. Payne, Antoine M. van Oijen, Joel P. Mackay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/848eae28baf44153b8dee9ed3f4508b7
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spelling	oai:doaj.org-article:848eae28baf44153b8dee9ed3f4508b72021-12-02T15:34:13ZCHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation10.1038/s41467-020-15183-22041-1723https://doaj.org/article/848eae28baf44153b8dee9ed3f4508b72020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15183-2https://doaj.org/toc/2041-1723Chromatin remodellers hydrolyse ATP to move nucleosomal DNA against histone octamers. Here, the authors use single-molecule assays to examine the mechanism of action of CHD4 remodeller, and provide evidence that CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation.Yichen ZhongBishnu P. PaudelDaniel P. RyanJason K. K. LowCharlotte FranckKarishma PatelMax J. BedwardMario TorradoRichard J. PayneAntoine M. van OijenJoel P. MackayNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yichen Zhong Bishnu P. Paudel Daniel P. Ryan Jason K. K. Low Charlotte Franck Karishma Patel Max J. Bedward Mario Torrado Richard J. Payne Antoine M. van Oijen Joel P. Mackay CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation
description	Chromatin remodellers hydrolyse ATP to move nucleosomal DNA against histone octamers. Here, the authors use single-molecule assays to examine the mechanism of action of CHD4 remodeller, and provide evidence that CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation.
format	article
author	Yichen Zhong Bishnu P. Paudel Daniel P. Ryan Jason K. K. Low Charlotte Franck Karishma Patel Max J. Bedward Mario Torrado Richard J. Payne Antoine M. van Oijen Joel P. Mackay
author_facet	Yichen Zhong Bishnu P. Paudel Daniel P. Ryan Jason K. K. Low Charlotte Franck Karishma Patel Max J. Bedward Mario Torrado Richard J. Payne Antoine M. van Oijen Joel P. Mackay
author_sort	Yichen Zhong
title	CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation
title_short	CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation
title_full	CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation
title_fullStr	CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation
title_full_unstemmed	CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation
title_sort	chd4 slides nucleosomes by decoupling entry- and exit-side dna translocation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/848eae28baf44153b8dee9ed3f4508b7
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CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation

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