Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites

Alsayed AM Elsherbini1, Mahmoud Saber2, Mohamed Aggag2, Ahmed El-Shahawy2, Hesham AA Shokier11National Institute of Laser Enhanced Science, 2Children&#39;s Cancer Hospital, Cairo, EgyptIntroduction: The current radiofrequency ablation technique requires invasive needle placement. On the othe...

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Autores principales:	Elsherbini AAM, Saber M, Aggag M, El-Shahawy A, Shokier HAA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/848f1d67dc6642489d4eaf2e5c9b06a1
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spelling	oai:doaj.org-article:848f1d67dc6642489d4eaf2e5c9b06a12021-12-02T08:08:33ZLaser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites1176-91141178-2013https://doaj.org/article/848f1d67dc6642489d4eaf2e5c9b06a12011-09-01T00:00:00Zhttp://www.dovepress.com/laser-and-radiofrequency-induced-hyperthermia-treatment-via-gold-coate-a8377https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Alsayed AM Elsherbini1, Mahmoud Saber2, Mohamed Aggag2, Ahmed El-Shahawy2, Hesham AA Shokier11National Institute of Laser Enhanced Science, 2Children&#39;s Cancer Hospital, Cairo, EgyptIntroduction: The current radiofrequency ablation technique requires invasive needle placement. On the other hand, most of the common photothermal therapeutic methods are limited by lack of accuracy of targeting. Gold and magnetic nanoparticles offer the potential to heat tumor tissue selectively at the cellular level by noninvasive interaction with laser and radiofrequency.Methods: Gold nanospheres and gold-coated magnetic nanocomposites were used for inducing hyperthermia to treat subcutaneous Ehrlich carcinoma implanted in female mice.Results: In mice treated with gold nanospheres, tumors continued to grow but at a slow rate. In contrast, more than 50% of the tumors treated with gold-coated magnetic nanocomposites completely disappeared.Conclusion: This simple and noninvasive method shows great promise as a technique for selective magnetic photothermal treatment.Keywords: laser, hyperthermia, gold magnetic nanocomposites, Ehrlich carcinomaElsherbini AAMSaber MAggag MEl-Shahawy AShokier HAADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 2155-2165 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Elsherbini AAM Saber M Aggag M El-Shahawy A Shokier HAA Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites
description	Alsayed AM Elsherbini1, Mahmoud Saber2, Mohamed Aggag2, Ahmed El-Shahawy2, Hesham AA Shokier11National Institute of Laser Enhanced Science, 2Children&#39;s Cancer Hospital, Cairo, EgyptIntroduction: The current radiofrequency ablation technique requires invasive needle placement. On the other hand, most of the common photothermal therapeutic methods are limited by lack of accuracy of targeting. Gold and magnetic nanoparticles offer the potential to heat tumor tissue selectively at the cellular level by noninvasive interaction with laser and radiofrequency.Methods: Gold nanospheres and gold-coated magnetic nanocomposites were used for inducing hyperthermia to treat subcutaneous Ehrlich carcinoma implanted in female mice.Results: In mice treated with gold nanospheres, tumors continued to grow but at a slow rate. In contrast, more than 50% of the tumors treated with gold-coated magnetic nanocomposites completely disappeared.Conclusion: This simple and noninvasive method shows great promise as a technique for selective magnetic photothermal treatment.Keywords: laser, hyperthermia, gold magnetic nanocomposites, Ehrlich carcinoma
format	article
author	Elsherbini AAM Saber M Aggag M El-Shahawy A Shokier HAA
author_facet	Elsherbini AAM Saber M Aggag M El-Shahawy A Shokier HAA
author_sort	Elsherbini AAM
title	Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites
title_short	Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites
title_full	Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites
title_fullStr	Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites
title_full_unstemmed	Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites
title_sort	laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/848f1d67dc6642489d4eaf2e5c9b06a1
work_keys_str_mv	AT elsherbiniaam laserandradiofrequencyinducedhyperthermiatreatmentviagoldcoatedmagneticnanocomposites AT saberm laserandradiofrequencyinducedhyperthermiatreatmentviagoldcoatedmagneticnanocomposites AT aggagm laserandradiofrequencyinducedhyperthermiatreatmentviagoldcoatedmagneticnanocomposites AT elshahawya laserandradiofrequencyinducedhyperthermiatreatmentviagoldcoatedmagneticnanocomposites AT shokierhaa laserandradiofrequencyinducedhyperthermiatreatmentviagoldcoatedmagneticnanocomposites
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Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites

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