No impact of gestational diabetes mellitus on pregnancy complications in women with PCOS, regardless of GDM criteria used.

Polycystic ovary syndrome (PCOS) is characterized by the presence of insulin resistance, and women with PCOS have high prevalence of gestational diabetes (GDM). Both conditions have been associated with increased risk for pregnancy complications such as preterm birth, preeclampsia and increased offs...

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Autores principales:	Stine Lyngvi Fougner, Eszter Vanky, Tone Shetelig Løvvik, Sven Magnus Carlsen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/849143672a264167a02eedcc7cddc313
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spelling	oai:doaj.org-article:849143672a264167a02eedcc7cddc3132021-12-02T20:04:52ZNo impact of gestational diabetes mellitus on pregnancy complications in women with PCOS, regardless of GDM criteria used.1932-620310.1371/journal.pone.0254895https://doaj.org/article/849143672a264167a02eedcc7cddc3132021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254895https://doaj.org/toc/1932-6203Polycystic ovary syndrome (PCOS) is characterized by the presence of insulin resistance, and women with PCOS have high prevalence of gestational diabetes (GDM). Both conditions have been associated with increased risk for pregnancy complications such as preterm birth, preeclampsia and increased offspring birth weight. We aimed to estimate the prevalence of GDM in women with PCOS using both previous and new diagnostic criteria, and to analyse whether the risk of pregnancy complications increased with the presence of GDM. In addition, we aimed to assess the response to metformin treatment in PCOS women with GDM. We performed post-hoc analysis of three prospective, double blinded studies of altogether 791 pregnant women with PCOS randomized to either metformin or placebo treatment from first trimester to delivery. Glucose data allowing GDM classification after previous (WHO 1999) and new (WHO 2013 and Norwegian 2017) diagnostic criteria were available for 722 of the women. Complications such as preeclampsia, late miscarriage and preterm birth, birth weight and gestational age were correlated to the presence of GDM and metformin treatment. The prevalence of GDM was 28.3% (WHO 1999), 41.2% (WHO 2013) and 27.2% (Norwegian 2017). Having GDM already in first trimester associated with increased risk for late miscarriage (p<0.01). Having GDM according to newer criteria correlated to increased maternal age and BMI (p<0.001). Otherwise, having GDM (any criteria) correlated neither to the development of preeclampsia, nor to birth weight z-score or the proportion of offspring being large for gestational weight. Maternal age and BMI, parity and gestational weight gain, but not GDM or metformin treatment, were determinants for birth weight z-score. Conclusion: in pregnant women with PCOS, having GDM did not increase the risk for other pregnancy complications except for an increased risk for late miscarriage among those with GDM already in the first trimester.Stine Lyngvi FougnerEszter VankyTone Shetelig LøvvikSven Magnus CarlsenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254895 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stine Lyngvi Fougner Eszter Vanky Tone Shetelig Løvvik Sven Magnus Carlsen No impact of gestational diabetes mellitus on pregnancy complications in women with PCOS, regardless of GDM criteria used.
description	Polycystic ovary syndrome (PCOS) is characterized by the presence of insulin resistance, and women with PCOS have high prevalence of gestational diabetes (GDM). Both conditions have been associated with increased risk for pregnancy complications such as preterm birth, preeclampsia and increased offspring birth weight. We aimed to estimate the prevalence of GDM in women with PCOS using both previous and new diagnostic criteria, and to analyse whether the risk of pregnancy complications increased with the presence of GDM. In addition, we aimed to assess the response to metformin treatment in PCOS women with GDM. We performed post-hoc analysis of three prospective, double blinded studies of altogether 791 pregnant women with PCOS randomized to either metformin or placebo treatment from first trimester to delivery. Glucose data allowing GDM classification after previous (WHO 1999) and new (WHO 2013 and Norwegian 2017) diagnostic criteria were available for 722 of the women. Complications such as preeclampsia, late miscarriage and preterm birth, birth weight and gestational age were correlated to the presence of GDM and metformin treatment. The prevalence of GDM was 28.3% (WHO 1999), 41.2% (WHO 2013) and 27.2% (Norwegian 2017). Having GDM already in first trimester associated with increased risk for late miscarriage (p<0.01). Having GDM according to newer criteria correlated to increased maternal age and BMI (p<0.001). Otherwise, having GDM (any criteria) correlated neither to the development of preeclampsia, nor to birth weight z-score or the proportion of offspring being large for gestational weight. Maternal age and BMI, parity and gestational weight gain, but not GDM or metformin treatment, were determinants for birth weight z-score. Conclusion: in pregnant women with PCOS, having GDM did not increase the risk for other pregnancy complications except for an increased risk for late miscarriage among those with GDM already in the first trimester.
format	article
author	Stine Lyngvi Fougner Eszter Vanky Tone Shetelig Løvvik Sven Magnus Carlsen
author_facet	Stine Lyngvi Fougner Eszter Vanky Tone Shetelig Løvvik Sven Magnus Carlsen
author_sort	Stine Lyngvi Fougner
title	No impact of gestational diabetes mellitus on pregnancy complications in women with PCOS, regardless of GDM criteria used.
title_short	No impact of gestational diabetes mellitus on pregnancy complications in women with PCOS, regardless of GDM criteria used.
title_full	No impact of gestational diabetes mellitus on pregnancy complications in women with PCOS, regardless of GDM criteria used.
title_fullStr	No impact of gestational diabetes mellitus on pregnancy complications in women with PCOS, regardless of GDM criteria used.
title_full_unstemmed	No impact of gestational diabetes mellitus on pregnancy complications in women with PCOS, regardless of GDM criteria used.
title_sort	no impact of gestational diabetes mellitus on pregnancy complications in women with pcos, regardless of gdm criteria used.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/849143672a264167a02eedcc7cddc313
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No impact of gestational diabetes mellitus on pregnancy complications in women with PCOS, regardless of GDM criteria used.

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