THE DEPOSIT OF ANTIBODY’S PROLIFERATIVE ACTIVITY IN THE IMMUNE RESPONSE AND ITS RESISTANCE TO INHIBITORS OF PROLIFERATION
The effect of hyperstimulation of the primary immune response was showed by additional introducing of antigen in the late log-phase of the primary IgM-response. The multiple increase of IgM-and IgG-antibody productive cells (АРС) in the spleen during the primary response was accompanied by suppressi...
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Scientific Сentre for Family Health and Human Reproduction Problems
2012
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oai:doaj.org-article:84950dc9177f498ab345c276d037e0af2021-11-23T06:14:19ZTHE DEPOSIT OF ANTIBODY’S PROLIFERATIVE ACTIVITY IN THE IMMUNE RESPONSE AND ITS RESISTANCE TO INHIBITORS OF PROLIFERATION2541-94202587-9596https://doaj.org/article/84950dc9177f498ab345c276d037e0af2012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/930https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The effect of hyperstimulation of the primary immune response was showed by additional introducing of antigen in the late log-phase of the primary IgM-response. The multiple increase of IgM-and IgG-antibody productive cells (АРС) in the spleen during the primary response was accompanied by suppression of anamnestic response. The injection of hydroxyurea (an inhibitor of DNA synthesis) together with the additional introduction of the antigen at the late log-phase of the primary IgM-response reduces the rise of IgM-APC, but does not abolish the stimulation of the primary and secondary IgG-APC formation. This fact indicates that proliferative processes play an important role in the stimulation of IgM-response induced by reinjection of the antigen. The stimulation of proliferation of B-lymphocytes which differentiate into antibody productive cells significantly reduces the pool of memory cells and consequently, suppresses secondary immune response.E. D. GavrilovaO. T. KudayevaO. P. KolesnikovaV. A. KozlovScientific Сentre for Family Health and Human Reproduction Problemsarticleigm- и igg-антителообразующие клеткиigm- and igg-antibody producing cellshydroxyurea, the immune memoryScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 260-263 (2012) |
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DOAJ |
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DOAJ |
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RU |
| topic |
igm- и igg-антителообразующие клетки igm- and igg-antibody producing cells hydroxyurea, the immune memory Science Q |
| spellingShingle |
igm- и igg-антителообразующие клетки igm- and igg-antibody producing cells hydroxyurea, the immune memory Science Q E. D. Gavrilova O. T. Kudayeva O. P. Kolesnikova V. A. Kozlov THE DEPOSIT OF ANTIBODY’S PROLIFERATIVE ACTIVITY IN THE IMMUNE RESPONSE AND ITS RESISTANCE TO INHIBITORS OF PROLIFERATION |
| description |
The effect of hyperstimulation of the primary immune response was showed by additional introducing of antigen in the late log-phase of the primary IgM-response. The multiple increase of IgM-and IgG-antibody productive cells (АРС) in the spleen during the primary response was accompanied by suppression of anamnestic response. The injection of hydroxyurea (an inhibitor of DNA synthesis) together with the additional introduction of the antigen at the late log-phase of the primary IgM-response reduces the rise of IgM-APC, but does not abolish the stimulation of the primary and secondary IgG-APC formation. This fact indicates that proliferative processes play an important role in the stimulation of IgM-response induced by reinjection of the antigen. The stimulation of proliferation of B-lymphocytes which differentiate into antibody productive cells significantly reduces the pool of memory cells and consequently, suppresses secondary immune response. |
| format |
article |
| author |
E. D. Gavrilova O. T. Kudayeva O. P. Kolesnikova V. A. Kozlov |
| author_facet |
E. D. Gavrilova O. T. Kudayeva O. P. Kolesnikova V. A. Kozlov |
| author_sort |
E. D. Gavrilova |
| title |
THE DEPOSIT OF ANTIBODY’S PROLIFERATIVE ACTIVITY IN THE IMMUNE RESPONSE AND ITS RESISTANCE TO INHIBITORS OF PROLIFERATION |
| title_short |
THE DEPOSIT OF ANTIBODY’S PROLIFERATIVE ACTIVITY IN THE IMMUNE RESPONSE AND ITS RESISTANCE TO INHIBITORS OF PROLIFERATION |
| title_full |
THE DEPOSIT OF ANTIBODY’S PROLIFERATIVE ACTIVITY IN THE IMMUNE RESPONSE AND ITS RESISTANCE TO INHIBITORS OF PROLIFERATION |
| title_fullStr |
THE DEPOSIT OF ANTIBODY’S PROLIFERATIVE ACTIVITY IN THE IMMUNE RESPONSE AND ITS RESISTANCE TO INHIBITORS OF PROLIFERATION |
| title_full_unstemmed |
THE DEPOSIT OF ANTIBODY’S PROLIFERATIVE ACTIVITY IN THE IMMUNE RESPONSE AND ITS RESISTANCE TO INHIBITORS OF PROLIFERATION |
| title_sort |
deposit of antibody’s proliferative activity in the immune response and its resistance to inhibitors of proliferation |
| publisher |
Scientific Сentre for Family Health and Human Reproduction Problems |
| publishDate |
2012 |
| url |
https://doaj.org/article/84950dc9177f498ab345c276d037e0af |
| work_keys_str_mv |
AT edgavrilova thedepositofantibodysproliferativeactivityintheimmuneresponseanditsresistancetoinhibitorsofproliferation AT otkudayeva thedepositofantibodysproliferativeactivityintheimmuneresponseanditsresistancetoinhibitorsofproliferation AT opkolesnikova thedepositofantibodysproliferativeactivityintheimmuneresponseanditsresistancetoinhibitorsofproliferation AT vakozlov thedepositofantibodysproliferativeactivityintheimmuneresponseanditsresistancetoinhibitorsofproliferation AT edgavrilova depositofantibodysproliferativeactivityintheimmuneresponseanditsresistancetoinhibitorsofproliferation AT otkudayeva depositofantibodysproliferativeactivityintheimmuneresponseanditsresistancetoinhibitorsofproliferation AT opkolesnikova depositofantibodysproliferativeactivityintheimmuneresponseanditsresistancetoinhibitorsofproliferation AT vakozlov depositofantibodysproliferativeactivityintheimmuneresponseanditsresistancetoinhibitorsofproliferation |
| _version_ |
1718417330344558592 |