Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice

Abstract The immune system plays a role in the maintenance of healthy neurocognitive function. Different patterns of immune response triggered by distinct stimuli may affect nervous functions through regulatory or deregulatory signals, depending on the properties of the exogenous immunogens. Here, w...

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Autores principales:	Luciana Pereira de Sousa, Flávia Lima Ribeiro-Gomes, Roberto Farina de Almeida, Tadeu Mello e Souza, Guilherme Loureiro Werneck, Diogo Onofre Souza, Cláudio Tadeu Daniel-Ribeiro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/849797976ac3456f824fc19d446e56a2
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spelling	oai:doaj.org-article:849797976ac3456f824fc19d446e56a22021-12-02T17:55:13ZImmune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice10.1038/s41598-021-94167-82045-2322https://doaj.org/article/849797976ac3456f824fc19d446e56a22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94167-8https://doaj.org/toc/2045-2322Abstract The immune system plays a role in the maintenance of healthy neurocognitive function. Different patterns of immune response triggered by distinct stimuli may affect nervous functions through regulatory or deregulatory signals, depending on the properties of the exogenous immunogens. Here, we investigate the effect of immune stimulation on cognitive-behavioural parameters in healthy mice and its impact on cognitive sequelae resulting from non-severe experimental malaria. We show that immune modulation induced by a specific combination of immune stimuli that induce a type 2 immune response can enhance long-term recognition memory in healthy adult mice subjected to novel object recognition task (NORT) and reverse a lack of recognition ability in NORT and anxiety-like behaviour in a light/dark task that result from a single episode of mild Plasmodium berghei ANKA malaria. Our findings suggest a potential use of immunogens for boosting and recovering recognition memory that may be impaired by chronic and infectious diseases and by the effects of ageing.Luciana Pereira de SousaFlávia Lima Ribeiro-GomesRoberto Farina de AlmeidaTadeu Mello e SouzaGuilherme Loureiro WerneckDiogo Onofre SouzaCláudio Tadeu Daniel-RibeiroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luciana Pereira de Sousa Flávia Lima Ribeiro-Gomes Roberto Farina de Almeida Tadeu Mello e Souza Guilherme Loureiro Werneck Diogo Onofre Souza Cláudio Tadeu Daniel-Ribeiro Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice
description	Abstract The immune system plays a role in the maintenance of healthy neurocognitive function. Different patterns of immune response triggered by distinct stimuli may affect nervous functions through regulatory or deregulatory signals, depending on the properties of the exogenous immunogens. Here, we investigate the effect of immune stimulation on cognitive-behavioural parameters in healthy mice and its impact on cognitive sequelae resulting from non-severe experimental malaria. We show that immune modulation induced by a specific combination of immune stimuli that induce a type 2 immune response can enhance long-term recognition memory in healthy adult mice subjected to novel object recognition task (NORT) and reverse a lack of recognition ability in NORT and anxiety-like behaviour in a light/dark task that result from a single episode of mild Plasmodium berghei ANKA malaria. Our findings suggest a potential use of immunogens for boosting and recovering recognition memory that may be impaired by chronic and infectious diseases and by the effects of ageing.
format	article
author	Luciana Pereira de Sousa Flávia Lima Ribeiro-Gomes Roberto Farina de Almeida Tadeu Mello e Souza Guilherme Loureiro Werneck Diogo Onofre Souza Cláudio Tadeu Daniel-Ribeiro
author_facet	Luciana Pereira de Sousa Flávia Lima Ribeiro-Gomes Roberto Farina de Almeida Tadeu Mello e Souza Guilherme Loureiro Werneck Diogo Onofre Souza Cláudio Tadeu Daniel-Ribeiro
author_sort	Luciana Pereira de Sousa
title	Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice
title_short	Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice
title_full	Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice
title_fullStr	Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice
title_full_unstemmed	Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice
title_sort	immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/849797976ac3456f824fc19d446e56a2
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Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice

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