The prognostic value of peripheral total and differential leukocyte count in renal progression: A community-based study.

<h4>Background</h4>Systemic inflammation is related to chronic kidney disease (CKD) patients. Elevated peripheral leukocyte count may be a herald of increased systemic inflammation and subclinical disease. Inflammation plays an important role in renal progression. The pattern of total an...

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Autores principales:	Chiung-Hui Yen, I-Wen Wu, Chin-Chan Lee, Kuang-Hung Hsu, Chiao-Yin Sun, Chun-Yu Chen, Heng-Chih Pan, Heng Jung Hsu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/849aa8467d294876a5affd8a25b22822
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spelling	oai:doaj.org-article:849aa8467d294876a5affd8a25b228222021-12-02T20:13:25ZThe prognostic value of peripheral total and differential leukocyte count in renal progression: A community-based study.1932-620310.1371/journal.pone.0258210https://doaj.org/article/849aa8467d294876a5affd8a25b228222021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258210https://doaj.org/toc/1932-6203<h4>Background</h4>Systemic inflammation is related to chronic kidney disease (CKD) patients. Elevated peripheral leukocyte count may be a herald of increased systemic inflammation and subclinical disease. Inflammation plays an important role in renal progression. The pattern of total and differential leukocyte count in CKD is not well understood. Besides, the association between total and differential leukocyte count and renal progression is still uncertain.<h4>Methods</h4>We conducted a community-based cohort study with a follow-up period of two years to evaluate the total and differential leukocyte counts and renal progression association.<h4>Results</h4>In our study population from the community with a total number of 2128, we found 15.7% (335/2128) CKD patients with a mean estimated glomerular filtration rate (eGFR) around 96 ± 26 ml/min/1.73 m2. The peripheral total leukocyte count and also differential leukocyte count were significantly negatively correlated with eGFR. A total of 56 patients (3%) experienced a rapid progression of the kidney with the definition of eGFR reduction changes of 30% or greater within two years. Univariate analysis indicated that rapid renal progression was significantly associated with male gender, co-morbidity of diabetes mellitus (DM), higher uric acid levels, higher peripheral neutrophil, monocyte, and eosinophil counts. However, only the peripheral neutrophil count was positively and independently associated with rapid renal progression after multivariate analysis. The ROC curve analysis found that the optimal cutoff value of peripheral neutrophil count for rapid progression was 2760/ mm3, with an area under the curve of 0.813.<h4>Conclusion</h4>Hyperinflammation with higher peripheral total and differential leukocyte count was noted in CKD patients. The peripheral neutrophil count was the only independent factor significantly associated with rapid renal progression. The optimal cutoff point of the peripheral neutrophil count with 2760/mm3 is useful for determining the high-risk population for rapid renal progression with a satisfying sensitivity and specificity.Chiung-Hui YenI-Wen WuChin-Chan LeeKuang-Hung HsuChiao-Yin SunChun-Yu ChenHeng-Chih PanHeng Jung HsuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258210 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chiung-Hui Yen I-Wen Wu Chin-Chan Lee Kuang-Hung Hsu Chiao-Yin Sun Chun-Yu Chen Heng-Chih Pan Heng Jung Hsu The prognostic value of peripheral total and differential leukocyte count in renal progression: A community-based study.
description	<h4>Background</h4>Systemic inflammation is related to chronic kidney disease (CKD) patients. Elevated peripheral leukocyte count may be a herald of increased systemic inflammation and subclinical disease. Inflammation plays an important role in renal progression. The pattern of total and differential leukocyte count in CKD is not well understood. Besides, the association between total and differential leukocyte count and renal progression is still uncertain.<h4>Methods</h4>We conducted a community-based cohort study with a follow-up period of two years to evaluate the total and differential leukocyte counts and renal progression association.<h4>Results</h4>In our study population from the community with a total number of 2128, we found 15.7% (335/2128) CKD patients with a mean estimated glomerular filtration rate (eGFR) around 96 ± 26 ml/min/1.73 m2. The peripheral total leukocyte count and also differential leukocyte count were significantly negatively correlated with eGFR. A total of 56 patients (3%) experienced a rapid progression of the kidney with the definition of eGFR reduction changes of 30% or greater within two years. Univariate analysis indicated that rapid renal progression was significantly associated with male gender, co-morbidity of diabetes mellitus (DM), higher uric acid levels, higher peripheral neutrophil, monocyte, and eosinophil counts. However, only the peripheral neutrophil count was positively and independently associated with rapid renal progression after multivariate analysis. The ROC curve analysis found that the optimal cutoff value of peripheral neutrophil count for rapid progression was 2760/ mm3, with an area under the curve of 0.813.<h4>Conclusion</h4>Hyperinflammation with higher peripheral total and differential leukocyte count was noted in CKD patients. The peripheral neutrophil count was the only independent factor significantly associated with rapid renal progression. The optimal cutoff point of the peripheral neutrophil count with 2760/mm3 is useful for determining the high-risk population for rapid renal progression with a satisfying sensitivity and specificity.
format	article
author	Chiung-Hui Yen I-Wen Wu Chin-Chan Lee Kuang-Hung Hsu Chiao-Yin Sun Chun-Yu Chen Heng-Chih Pan Heng Jung Hsu
author_facet	Chiung-Hui Yen I-Wen Wu Chin-Chan Lee Kuang-Hung Hsu Chiao-Yin Sun Chun-Yu Chen Heng-Chih Pan Heng Jung Hsu
author_sort	Chiung-Hui Yen
title	The prognostic value of peripheral total and differential leukocyte count in renal progression: A community-based study.
title_short	The prognostic value of peripheral total and differential leukocyte count in renal progression: A community-based study.
title_full	The prognostic value of peripheral total and differential leukocyte count in renal progression: A community-based study.
title_fullStr	The prognostic value of peripheral total and differential leukocyte count in renal progression: A community-based study.
title_full_unstemmed	The prognostic value of peripheral total and differential leukocyte count in renal progression: A community-based study.
title_sort	prognostic value of peripheral total and differential leukocyte count in renal progression: a community-based study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/849aa8467d294876a5affd8a25b22822
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The prognostic value of peripheral total and differential leukocyte count in renal progression: A community-based study.

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