SPECIFIC IMMUNOTHERAPY AND CELLULAR IMMUNITY IN PATIENTS WITH CERVICAL CANCER

Cellular mechanisms are quite important immunological components of tumor surveillance, being, however, most vulnerable to influence of different adverse factors, including surgery-associated stress and ionizing radiation. Our study was aimed for assessing specific effects of immunotherapy upon indi...

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Autores principales:	D. K. Kenbaeva, A. F. Lazarev, Z. A. Manambaeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cervical cancer specific immunotherapy cellular immunity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/849b32c3144546319a77c87f61ed8098
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spelling	oai:doaj.org-article:849b32c3144546319a77c87f61ed80982021-11-18T08:03:37ZSPECIFIC IMMUNOTHERAPY AND CELLULAR IMMUNITY IN PATIENTS WITH CERVICAL CANCER1563-06252313-741X10.15789/1563-0625-2013-1-55-60https://doaj.org/article/849b32c3144546319a77c87f61ed80982014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/39https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XCellular mechanisms are quite important immunological components of tumor surveillance, being, however, most vulnerable to influence of different adverse factors, including surgery-associated stress and ionizing radiation. Our study was aimed for assessing specific effects of immunotherapy upon indices of cellular immunity in patients with cervical cancer. Eighty-eight patients with cervical cancer (clinical stage I-IIA, Т1аN0M0-T2aN0M0), who underwent appropriate surgery (for IA stage), or a combined treatment, including surgery gamma-ray teletherapy (IB, IIA stages) are under study. The patients were distributed in two groups, depending on the therapy applied. Group 1 included patients subjected to surgical treatment plus and radiation therapy, Group 2 included those patients who were treated according to this protocol, with addition of a specific immunotherapy. Contents of T cells and various CD subpopulations of T-lymphocytes were identified by immunofluorescence techniques. Among patients with cervical cancer at clinical stages IA, IB, IIA, a reliable decrease in cellular immunity indices was registered, both after surgery, and during combined treatment. Introduction of specific immunotherapy to the conventional treatment schedule was associated with increase of cellular immune indices, and, in first line, the antineoplastic mechanisms (e.g., NK’s and NKT cell contents). One should point to a relatively low efficiency of this immunotherapy in combined treatment of patients with cervical cancer at IIA stage.D. K. KenbaevaA. F. LazarevZ. A. ManambaevaSPb RAACIarticlecervical cancerspecific immunotherapycellular immunityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 1, Pp 55-60 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cervical cancer specific immunotherapy cellular immunity Immunologic diseases. Allergy RC581-607
spellingShingle	cervical cancer specific immunotherapy cellular immunity Immunologic diseases. Allergy RC581-607 D. K. Kenbaeva A. F. Lazarev Z. A. Manambaeva SPECIFIC IMMUNOTHERAPY AND CELLULAR IMMUNITY IN PATIENTS WITH CERVICAL CANCER
description	Cellular mechanisms are quite important immunological components of tumor surveillance, being, however, most vulnerable to influence of different adverse factors, including surgery-associated stress and ionizing radiation. Our study was aimed for assessing specific effects of immunotherapy upon indices of cellular immunity in patients with cervical cancer. Eighty-eight patients with cervical cancer (clinical stage I-IIA, Т1аN0M0-T2aN0M0), who underwent appropriate surgery (for IA stage), or a combined treatment, including surgery gamma-ray teletherapy (IB, IIA stages) are under study. The patients were distributed in two groups, depending on the therapy applied. Group 1 included patients subjected to surgical treatment plus and radiation therapy, Group 2 included those patients who were treated according to this protocol, with addition of a specific immunotherapy. Contents of T cells and various CD subpopulations of T-lymphocytes were identified by immunofluorescence techniques. Among patients with cervical cancer at clinical stages IA, IB, IIA, a reliable decrease in cellular immunity indices was registered, both after surgery, and during combined treatment. Introduction of specific immunotherapy to the conventional treatment schedule was associated with increase of cellular immune indices, and, in first line, the antineoplastic mechanisms (e.g., NK’s and NKT cell contents). One should point to a relatively low efficiency of this immunotherapy in combined treatment of patients with cervical cancer at IIA stage.
format	article
author	D. K. Kenbaeva A. F. Lazarev Z. A. Manambaeva
author_facet	D. K. Kenbaeva A. F. Lazarev Z. A. Manambaeva
author_sort	D. K. Kenbaeva
title	SPECIFIC IMMUNOTHERAPY AND CELLULAR IMMUNITY IN PATIENTS WITH CERVICAL CANCER
title_short	SPECIFIC IMMUNOTHERAPY AND CELLULAR IMMUNITY IN PATIENTS WITH CERVICAL CANCER
title_full	SPECIFIC IMMUNOTHERAPY AND CELLULAR IMMUNITY IN PATIENTS WITH CERVICAL CANCER
title_fullStr	SPECIFIC IMMUNOTHERAPY AND CELLULAR IMMUNITY IN PATIENTS WITH CERVICAL CANCER
title_full_unstemmed	SPECIFIC IMMUNOTHERAPY AND CELLULAR IMMUNITY IN PATIENTS WITH CERVICAL CANCER
title_sort	specific immunotherapy and cellular immunity in patients with cervical cancer
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/849b32c3144546319a77c87f61ed8098
work_keys_str_mv	AT dkkenbaeva specificimmunotherapyandcellularimmunityinpatientswithcervicalcancer AT aflazarev specificimmunotherapyandcellularimmunityinpatientswithcervicalcancer AT zamanambaeva specificimmunotherapyandcellularimmunityinpatientswithcervicalcancer
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SPECIFIC IMMUNOTHERAPY AND CELLULAR IMMUNITY IN PATIENTS WITH CERVICAL CANCER

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