Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers

B cells are well known as key mediators of humoral immune responses via the production of antibodies. Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and provides the first line of immune protection at mucosal surfaces. However, IgA has long been a divisive molecule with resp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ziwen Zhong, Ke Nan, Meilin Weng, Ying Yue, Wenchang Zhou, Zhiqiang Wang, Yiwei Chu, Ronghua Liu, Changhong Miao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	B cells plasma cells immunoglobulin A tumor immunity class switching Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/849ea2bc75c440928c6a1581b0e8b6b3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:849ea2bc75c440928c6a1581b0e8b6b3
record_format	dspace
spelling	oai:doaj.org-article:849ea2bc75c440928c6a1581b0e8b6b32021-11-19T06:05:56ZPro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers1664-322410.3389/fimmu.2021.765044https://doaj.org/article/849ea2bc75c440928c6a1581b0e8b6b32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.765044/fullhttps://doaj.org/toc/1664-3224B cells are well known as key mediators of humoral immune responses via the production of antibodies. Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and provides the first line of immune protection at mucosal surfaces. However, IgA has long been a divisive molecule with respect to tumor progression. IgA exerts anti- or pro-tumor effect in different tumor types. In this review, we summarize emerging evidence regarding the production and effects of IgA and IgA+ cells in the tumor microenvironment (TME). Moreover, we discuss that the TME cytokines, host diet, microbiome, and metabolites play a pivotal role in controlling the class-switch recombination (CSR) of IgA. The analysis of intratumoral Ig repertoires and determination of metabolites that influence CSR may help establish novel therapeutic targets for the treatment of cancers.Ziwen ZhongZiwen ZhongKe NanMeilin WengYing YueWenchang ZhouZhiqiang WangYiwei ChuYiwei ChuRonghua LiuChanghong MiaoFrontiers Media S.A.articleB cellsplasma cellsimmunoglobulin Atumor immunityclass switchingImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	B cells plasma cells immunoglobulin A tumor immunity class switching Immunologic diseases. Allergy RC581-607
spellingShingle	B cells plasma cells immunoglobulin A tumor immunity class switching Immunologic diseases. Allergy RC581-607 Ziwen Zhong Ziwen Zhong Ke Nan Meilin Weng Ying Yue Wenchang Zhou Zhiqiang Wang Yiwei Chu Yiwei Chu Ronghua Liu Changhong Miao Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers
description	B cells are well known as key mediators of humoral immune responses via the production of antibodies. Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and provides the first line of immune protection at mucosal surfaces. However, IgA has long been a divisive molecule with respect to tumor progression. IgA exerts anti- or pro-tumor effect in different tumor types. In this review, we summarize emerging evidence regarding the production and effects of IgA and IgA+ cells in the tumor microenvironment (TME). Moreover, we discuss that the TME cytokines, host diet, microbiome, and metabolites play a pivotal role in controlling the class-switch recombination (CSR) of IgA. The analysis of intratumoral Ig repertoires and determination of metabolites that influence CSR may help establish novel therapeutic targets for the treatment of cancers.
format	article
author	Ziwen Zhong Ziwen Zhong Ke Nan Meilin Weng Ying Yue Wenchang Zhou Zhiqiang Wang Yiwei Chu Yiwei Chu Ronghua Liu Changhong Miao
author_facet	Ziwen Zhong Ziwen Zhong Ke Nan Meilin Weng Ying Yue Wenchang Zhou Zhiqiang Wang Yiwei Chu Yiwei Chu Ronghua Liu Changhong Miao
author_sort	Ziwen Zhong
title	Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers
title_short	Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers
title_full	Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers
title_fullStr	Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers
title_full_unstemmed	Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers
title_sort	pro- and anti- effects of immunoglobulin a- producing b cell in tumors and its triggers
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/849ea2bc75c440928c6a1581b0e8b6b3
work_keys_str_mv	AT ziwenzhong proandantieffectsofimmunoglobulinaproducingbcellintumorsanditstriggers AT ziwenzhong proandantieffectsofimmunoglobulinaproducingbcellintumorsanditstriggers AT kenan proandantieffectsofimmunoglobulinaproducingbcellintumorsanditstriggers AT meilinweng proandantieffectsofimmunoglobulinaproducingbcellintumorsanditstriggers AT yingyue proandantieffectsofimmunoglobulinaproducingbcellintumorsanditstriggers AT wenchangzhou proandantieffectsofimmunoglobulinaproducingbcellintumorsanditstriggers AT zhiqiangwang proandantieffectsofimmunoglobulinaproducingbcellintumorsanditstriggers AT yiweichu proandantieffectsofimmunoglobulinaproducingbcellintumorsanditstriggers AT yiweichu proandantieffectsofimmunoglobulinaproducingbcellintumorsanditstriggers AT ronghualiu proandantieffectsofimmunoglobulinaproducingbcellintumorsanditstriggers AT changhongmiao proandantieffectsofimmunoglobulinaproducingbcellintumorsanditstriggers
_version_	1718420324149624832

Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers

Ejemplares similares