Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults.

<h4>Background</h4>Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adu...

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Autores principales:	Salvatore Sotgia, Angelo Zinellu, Arduino A Mangoni, Gianfranco Pintus, John Attia, Ciriaco Carru, Mark McEvoy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84a13ebc515a46c884ff0b6b4c1cdc5f
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spelling	oai:doaj.org-article:84a13ebc515a46c884ff0b6b4c1cdc5f2021-11-18T08:39:03ZClinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults.1932-620310.1371/journal.pone.0084918https://doaj.org/article/84a13ebc515a46c884ff0b6b4c1cdc5f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24392160/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults.<h4>Methods</h4>Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55-85 years) randomly selected from the Hunter Community Study.<h4>Results</h4>Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78-1.33 µmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31-0.44) to 3.08 (90% CI 2.45-3.76) µmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial = -0.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial = -0.13; P = 0.0063).<h4>Conclusions</h4>A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of community-dwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration.Salvatore SotgiaAngelo ZinelluArduino A MangoniGianfranco PintusJohn AttiaCiriaco CarruMark McEvoyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e84918 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Salvatore Sotgia Angelo Zinellu Arduino A Mangoni Gianfranco Pintus John Attia Ciriaco Carru Mark McEvoy Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults.
description	<h4>Background</h4>Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults.<h4>Methods</h4>Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55-85 years) randomly selected from the Hunter Community Study.<h4>Results</h4>Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78-1.33 µmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31-0.44) to 3.08 (90% CI 2.45-3.76) µmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial = -0.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial = -0.13; P = 0.0063).<h4>Conclusions</h4>A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of community-dwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration.
format	article
author	Salvatore Sotgia Angelo Zinellu Arduino A Mangoni Gianfranco Pintus John Attia Ciriaco Carru Mark McEvoy
author_facet	Salvatore Sotgia Angelo Zinellu Arduino A Mangoni Gianfranco Pintus John Attia Ciriaco Carru Mark McEvoy
author_sort	Salvatore Sotgia
title	Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults.
title_short	Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults.
title_full	Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults.
title_fullStr	Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults.
title_full_unstemmed	Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults.
title_sort	clinical and biochemical correlates of serum l-ergothioneine concentrations in community-dwelling middle-aged and older adults.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/84a13ebc515a46c884ff0b6b4c1cdc5f
work_keys_str_mv	AT salvatoresotgia clinicalandbiochemicalcorrelatesofserumlergothioneineconcentrationsincommunitydwellingmiddleagedandolderadults AT angelozinellu clinicalandbiochemicalcorrelatesofserumlergothioneineconcentrationsincommunitydwellingmiddleagedandolderadults AT arduinoamangoni clinicalandbiochemicalcorrelatesofserumlergothioneineconcentrationsincommunitydwellingmiddleagedandolderadults AT gianfrancopintus clinicalandbiochemicalcorrelatesofserumlergothioneineconcentrationsincommunitydwellingmiddleagedandolderadults AT johnattia clinicalandbiochemicalcorrelatesofserumlergothioneineconcentrationsincommunitydwellingmiddleagedandolderadults AT ciriacocarru clinicalandbiochemicalcorrelatesofserumlergothioneineconcentrationsincommunitydwellingmiddleagedandolderadults AT markmcevoy clinicalandbiochemicalcorrelatesofserumlergothioneineconcentrationsincommunitydwellingmiddleagedandolderadults
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Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults.

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