Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis

Abstract The Sec61 complex translocates nascent polypeptides into and across the membrane of the endoplasmic reticulum (ER), providing access to the secretory pathway. In this study, we show that Ipomoeassin-F (Ipom-F), a selective inhibitor of protein entry into the ER lumen, blocks the in vitro tr...

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Auteurs principaux: Peristera Roboti, Sarah O’Keefe, Kwabena B. Duah, Wei Q. Shi, Stephen High
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/84a590a1a842429faa233bc88b29e96b
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