Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis

Abstract We aimed was to assess the factors influencing therapy choice and clinical outcome after 3–4 months in patients with cerebral venous sinus thrombosis (CVST). In a retrospective, bi-centric study, the set consisted of 82 consecutive CVST patients (61 females; mean age 33.5 ± 15.7 years). Fol...

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Autores principales:	Dagmar Krajíčková, Jiří Král, Roman Herzig, Ľudovít Klzo, Antonín Krajina, Jaroslav Havelka, Libor Šimůnek, Oldřich Vyšata, Tran Van Quang, Michal Bar, Martin Vališ
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84a94925fc5d4bd0b41bfdb89cb12f0c
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spelling	oai:doaj.org-article:84a94925fc5d4bd0b41bfdb89cb12f0c2021-12-02T11:43:36ZFactors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis10.1038/s41598-020-78434-82045-2322https://doaj.org/article/84a94925fc5d4bd0b41bfdb89cb12f0c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78434-8https://doaj.org/toc/2045-2322Abstract We aimed was to assess the factors influencing therapy choice and clinical outcome after 3–4 months in patients with cerebral venous sinus thrombosis (CVST). In a retrospective, bi-centric study, the set consisted of 82 consecutive CVST patients (61 females; mean age 33.5 ± 15.7 years). Following data were collected: baseline characteristics, presence of gender-specific risk factors (GSRF), location and extent of venous sinus impairment, clinical presentation, type of treatment, recanalization, presence of parenchymal lesions, and clinical outcome after 3–4 months (assessed using the modified Rankin Scale [mRS], with excellent outcome defined as mRS 0–1). Multivariate logistic regression analysis was used for statistical evaluation. After 3–4 months, complete recovery was achieved in 41 (50%) and excellent clinical outcome in 67 (81.7%) patients. Female sex (OR 0.11; p = 0.0189) and presence of focal neurologic deficit (OR 0.16; p = 0.0165) were identified as significant independent negative predictors and, the presence of GSRF (OR 15.63; p = 0.0011) as significant independent positive predictor of excellent clinical outcome. In conclusion, in our CVST patients, the presence of GSRF was associated with excellent clinical outcome, while the female sex itself was associated with poorer clinical outcome.Dagmar KrajíčkováJiří KrálRoman HerzigĽudovít KlzoAntonín KrajinaJaroslav HavelkaLibor ŠimůnekOldřich VyšataTran Van QuangMichal BarMartin VališNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dagmar Krajíčková Jiří Král Roman Herzig Ľudovít Klzo Antonín Krajina Jaroslav Havelka Libor Šimůnek Oldřich Vyšata Tran Van Quang Michal Bar Martin Vališ Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis
description	Abstract We aimed was to assess the factors influencing therapy choice and clinical outcome after 3–4 months in patients with cerebral venous sinus thrombosis (CVST). In a retrospective, bi-centric study, the set consisted of 82 consecutive CVST patients (61 females; mean age 33.5 ± 15.7 years). Following data were collected: baseline characteristics, presence of gender-specific risk factors (GSRF), location and extent of venous sinus impairment, clinical presentation, type of treatment, recanalization, presence of parenchymal lesions, and clinical outcome after 3–4 months (assessed using the modified Rankin Scale [mRS], with excellent outcome defined as mRS 0–1). Multivariate logistic regression analysis was used for statistical evaluation. After 3–4 months, complete recovery was achieved in 41 (50%) and excellent clinical outcome in 67 (81.7%) patients. Female sex (OR 0.11; p = 0.0189) and presence of focal neurologic deficit (OR 0.16; p = 0.0165) were identified as significant independent negative predictors and, the presence of GSRF (OR 15.63; p = 0.0011) as significant independent positive predictor of excellent clinical outcome. In conclusion, in our CVST patients, the presence of GSRF was associated with excellent clinical outcome, while the female sex itself was associated with poorer clinical outcome.
format	article
author	Dagmar Krajíčková Jiří Král Roman Herzig Ľudovít Klzo Antonín Krajina Jaroslav Havelka Libor Šimůnek Oldřich Vyšata Tran Van Quang Michal Bar Martin Vališ
author_facet	Dagmar Krajíčková Jiří Král Roman Herzig Ľudovít Klzo Antonín Krajina Jaroslav Havelka Libor Šimůnek Oldřich Vyšata Tran Van Quang Michal Bar Martin Vališ
author_sort	Dagmar Krajíčková
title	Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis
title_short	Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis
title_full	Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis
title_fullStr	Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis
title_full_unstemmed	Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis
title_sort	factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/84a94925fc5d4bd0b41bfdb89cb12f0c
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Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis

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