Predictors for affected stroke territory and outcome of acute stroke treatments are different for posterior versus anterior circulation stroke

Abstract Distinct patient characteristics have been proposed for ischaemic stroke in the anterior versus posterior circulation. However, data on functional outcome according to stroke territory in patients with acute stroke treatment are conflicting and information on outcome predictors is scarce. I...

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Autores principales:	H. Handelsmann, L. Herzog, Z. Kulcsar, A. R. Luft, S. Wegener
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84aaadb6ae064dfba8c16e36dd17a8c2
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spelling	oai:doaj.org-article:84aaadb6ae064dfba8c16e36dd17a8c22021-12-02T15:53:10ZPredictors for affected stroke territory and outcome of acute stroke treatments are different for posterior versus anterior circulation stroke10.1038/s41598-021-89871-42045-2322https://doaj.org/article/84aaadb6ae064dfba8c16e36dd17a8c22021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89871-4https://doaj.org/toc/2045-2322Abstract Distinct patient characteristics have been proposed for ischaemic stroke in the anterior versus posterior circulation. However, data on functional outcome according to stroke territory in patients with acute stroke treatment are conflicting and information on outcome predictors is scarce. In this retrospective study, we analysed functional outcome in 517 patients with stroke and thrombolysis and/or thrombectomy treated at the University Hospital Zurich. We compared clinical factors and performed multivariate logistic regression analyses investigating the effect of outcome predictors according to stroke territory. Of the 517 patients included, 80 (15.5%) suffered a posterior circulation stroke (PCS). PCS patients were less often female (32.5% vs. 45.5%, p = 0.031), received thrombectomy less often (28.7% vs. 48.3%, p = 0.001), and had lower median admission NIHSS scores (5 vs. 10, p < 0.001) as well as a better median three months functional outcome (mRS 1 vs. 2, p = 0.010). Predictors for functional outcome were admission NIHSS (OR 0.864, 95% CI 0.790–0.944, p = 0.001) in PCS and age (OR 0.952, 95% CI 0.935–0.970, p < 0.001), known symptom onset (OR 1.869, 95% CI 1.111–3.144, p = 0.018) and admission NIHSS (OR 0.840, 95% CI 0.806–0.876, p < 0.001) in ACS. Acutely treated PCS and ACS patients differed in their baseline and treatment characteristics. We identified specific functional outcome predictors of thrombolysis and/or thrombectomy success for each stroke territory.H. HandelsmannL. HerzogZ. KulcsarA. R. LuftS. WegenerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q H. Handelsmann L. Herzog Z. Kulcsar A. R. Luft S. Wegener Predictors for affected stroke territory and outcome of acute stroke treatments are different for posterior versus anterior circulation stroke
description	Abstract Distinct patient characteristics have been proposed for ischaemic stroke in the anterior versus posterior circulation. However, data on functional outcome according to stroke territory in patients with acute stroke treatment are conflicting and information on outcome predictors is scarce. In this retrospective study, we analysed functional outcome in 517 patients with stroke and thrombolysis and/or thrombectomy treated at the University Hospital Zurich. We compared clinical factors and performed multivariate logistic regression analyses investigating the effect of outcome predictors according to stroke territory. Of the 517 patients included, 80 (15.5%) suffered a posterior circulation stroke (PCS). PCS patients were less often female (32.5% vs. 45.5%, p = 0.031), received thrombectomy less often (28.7% vs. 48.3%, p = 0.001), and had lower median admission NIHSS scores (5 vs. 10, p < 0.001) as well as a better median three months functional outcome (mRS 1 vs. 2, p = 0.010). Predictors for functional outcome were admission NIHSS (OR 0.864, 95% CI 0.790–0.944, p = 0.001) in PCS and age (OR 0.952, 95% CI 0.935–0.970, p < 0.001), known symptom onset (OR 1.869, 95% CI 1.111–3.144, p = 0.018) and admission NIHSS (OR 0.840, 95% CI 0.806–0.876, p < 0.001) in ACS. Acutely treated PCS and ACS patients differed in their baseline and treatment characteristics. We identified specific functional outcome predictors of thrombolysis and/or thrombectomy success for each stroke territory.
format	article
author	H. Handelsmann L. Herzog Z. Kulcsar A. R. Luft S. Wegener
author_facet	H. Handelsmann L. Herzog Z. Kulcsar A. R. Luft S. Wegener
author_sort	H. Handelsmann
title	Predictors for affected stroke territory and outcome of acute stroke treatments are different for posterior versus anterior circulation stroke
title_short	Predictors for affected stroke territory and outcome of acute stroke treatments are different for posterior versus anterior circulation stroke
title_full	Predictors for affected stroke territory and outcome of acute stroke treatments are different for posterior versus anterior circulation stroke
title_fullStr	Predictors for affected stroke territory and outcome of acute stroke treatments are different for posterior versus anterior circulation stroke
title_full_unstemmed	Predictors for affected stroke territory and outcome of acute stroke treatments are different for posterior versus anterior circulation stroke
title_sort	predictors for affected stroke territory and outcome of acute stroke treatments are different for posterior versus anterior circulation stroke
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/84aaadb6ae064dfba8c16e36dd17a8c2
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Predictors for affected stroke territory and outcome of acute stroke treatments are different for posterior versus anterior circulation stroke

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