High burden of cerebral white matter lesion in 9 Asian cities

Abstract Age-related white matter lesion (WML) is considered a manifestation of sporadic cerebral small vessel disease and an important pathological substrate for dementia. Asia is notable for its large population with a looming dementia epidemic. Yet, the burden of WML and its associated risk facto...

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Autores principales:	Bonnie Yin Ka Lam, Brian Yiu, Encarnita Ampil, Christopher Li-Hsian Chen, Yustiani Dikot, Jacqueline C. Dominguez, Patel Vishal Ganeshbhai, Saima Hilal, Nagaendran Kandiah, SangYun Kim, Jun-Young Lee, Anam Paulus Ong, Vorapun Senanarong, Kam Tat Leung, Huali Wang, Yuan-Han Yang, Tingting Yong, Faheem Arshad, Suvarna Alladi, Samuel Wong, Ho Ko, Alexander Yuk Lun Lau, Vincent Chung Tong Mok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84af5f65d5c644439b039c732a61e419
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spelling	oai:doaj.org-article:84af5f65d5c644439b039c732a61e4192021-12-02T15:02:57ZHigh burden of cerebral white matter lesion in 9 Asian cities10.1038/s41598-021-90746-x2045-2322https://doaj.org/article/84af5f65d5c644439b039c732a61e4192021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90746-xhttps://doaj.org/toc/2045-2322Abstract Age-related white matter lesion (WML) is considered a manifestation of sporadic cerebral small vessel disease and an important pathological substrate for dementia. Asia is notable for its large population with a looming dementia epidemic. Yet, the burden of WML and its associated risk factors across different Asian societies are unknown. Subjects from 9 Asian cities (Bangkok, Bandung, Beijing, Bengaluru, Hong Kong, Kaohsiung, Manila, Seoul, and Singapore) were recruited (n = 5701) and classified into (i) stroke/transient ischemic attack (TIA), (ii) Alzheimer’s disease (AD)/mild cognitive impairment (MCI), or (iii) control groups. Data on vascular risk factors and cognitive performance were collected. The severity of WML was visually rated on MRI or CT. The prevalence of moderate-to-severe WML was the highest in subjects with stroke/TIA (43.3%). Bandung Indonesia showed the highest prevalence of WML, adjusted for age, sex, education, disease groups, and imaging modality. Hypertension and hyperlipidemia were significant risk factors for WML, and WML was negatively associated with MMSE in all groups. WML is highly prevalent in Asia and is associated with increasing age, hypertension, hyperlipidemia, and worse cognitive performance. Concerted efforts to prevent WML will alleviate the huge dementia burden in the rapidly aging Asian societies.Bonnie Yin Ka LamBrian YiuEncarnita AmpilChristopher Li-Hsian ChenYustiani DikotJacqueline C. DominguezPatel Vishal GaneshbhaiSaima HilalNagaendran KandiahSangYun KimJun-Young LeeAnam Paulus OngVorapun SenanarongKam Tat LeungHuali WangYuan-Han YangTingting YongFaheem ArshadSuvarna AlladiSamuel WongHo KoAlexander Yuk Lun LauVincent Chung Tong MokNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bonnie Yin Ka Lam Brian Yiu Encarnita Ampil Christopher Li-Hsian Chen Yustiani Dikot Jacqueline C. Dominguez Patel Vishal Ganeshbhai Saima Hilal Nagaendran Kandiah SangYun Kim Jun-Young Lee Anam Paulus Ong Vorapun Senanarong Kam Tat Leung Huali Wang Yuan-Han Yang Tingting Yong Faheem Arshad Suvarna Alladi Samuel Wong Ho Ko Alexander Yuk Lun Lau Vincent Chung Tong Mok High burden of cerebral white matter lesion in 9 Asian cities
description	Abstract Age-related white matter lesion (WML) is considered a manifestation of sporadic cerebral small vessel disease and an important pathological substrate for dementia. Asia is notable for its large population with a looming dementia epidemic. Yet, the burden of WML and its associated risk factors across different Asian societies are unknown. Subjects from 9 Asian cities (Bangkok, Bandung, Beijing, Bengaluru, Hong Kong, Kaohsiung, Manila, Seoul, and Singapore) were recruited (n = 5701) and classified into (i) stroke/transient ischemic attack (TIA), (ii) Alzheimer’s disease (AD)/mild cognitive impairment (MCI), or (iii) control groups. Data on vascular risk factors and cognitive performance were collected. The severity of WML was visually rated on MRI or CT. The prevalence of moderate-to-severe WML was the highest in subjects with stroke/TIA (43.3%). Bandung Indonesia showed the highest prevalence of WML, adjusted for age, sex, education, disease groups, and imaging modality. Hypertension and hyperlipidemia were significant risk factors for WML, and WML was negatively associated with MMSE in all groups. WML is highly prevalent in Asia and is associated with increasing age, hypertension, hyperlipidemia, and worse cognitive performance. Concerted efforts to prevent WML will alleviate the huge dementia burden in the rapidly aging Asian societies.
format	article
author	Bonnie Yin Ka Lam Brian Yiu Encarnita Ampil Christopher Li-Hsian Chen Yustiani Dikot Jacqueline C. Dominguez Patel Vishal Ganeshbhai Saima Hilal Nagaendran Kandiah SangYun Kim Jun-Young Lee Anam Paulus Ong Vorapun Senanarong Kam Tat Leung Huali Wang Yuan-Han Yang Tingting Yong Faheem Arshad Suvarna Alladi Samuel Wong Ho Ko Alexander Yuk Lun Lau Vincent Chung Tong Mok
author_facet	Bonnie Yin Ka Lam Brian Yiu Encarnita Ampil Christopher Li-Hsian Chen Yustiani Dikot Jacqueline C. Dominguez Patel Vishal Ganeshbhai Saima Hilal Nagaendran Kandiah SangYun Kim Jun-Young Lee Anam Paulus Ong Vorapun Senanarong Kam Tat Leung Huali Wang Yuan-Han Yang Tingting Yong Faheem Arshad Suvarna Alladi Samuel Wong Ho Ko Alexander Yuk Lun Lau Vincent Chung Tong Mok
author_sort	Bonnie Yin Ka Lam
title	High burden of cerebral white matter lesion in 9 Asian cities
title_short	High burden of cerebral white matter lesion in 9 Asian cities
title_full	High burden of cerebral white matter lesion in 9 Asian cities
title_fullStr	High burden of cerebral white matter lesion in 9 Asian cities
title_full_unstemmed	High burden of cerebral white matter lesion in 9 Asian cities
title_sort	high burden of cerebral white matter lesion in 9 asian cities
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/84af5f65d5c644439b039c732a61e419
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High burden of cerebral white matter lesion in 9 Asian cities

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