No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol

Abstract Inconsistent results have been reported for the association between alcohol use and pancreatic cancer, particularly at low levels of alcohol consumption. Individuals genetically susceptible to the carcinogenic effect of alcohol might have higher pancreatic cancer risk after drinking alcohol...

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Autores principales:	Yan-Shen Shan, Li-Tzong Chen, Chih-Hsing Wu, Yin-Fan Chang, Chih-Ting Lee, Nai-Jung Chiang, Ying-Jui Chao, Chia-Jui Yen, Hui-Jen Tsai, Hsin-En Huang, Chia-Rung Tsai, Ya-Ling Weng, Han-Chien Yang, Hui-Chin Liu, Jeffrey S. Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84b4b726eb174a59ad94d3a3577f65f1
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spelling	oai:doaj.org-article:84b4b726eb174a59ad94d3a3577f65f12021-12-02T16:08:07ZNo association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol10.1038/s41598-021-94111-w2045-2322https://doaj.org/article/84b4b726eb174a59ad94d3a3577f65f12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94111-whttps://doaj.org/toc/2045-2322Abstract Inconsistent results have been reported for the association between alcohol use and pancreatic cancer, particularly at low levels of alcohol consumption. Individuals genetically susceptible to the carcinogenic effect of alcohol might have higher pancreatic cancer risk after drinking alcohol. The current study investigated the association between alcohol use and pancreatic cancer with 419 pancreatic cancer cases and 963 controls recruited by a hospital-based case–control study in Taiwan. Gene-environment interaction between alcohol use and polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on pancreatic risk was evaluated. Our results showed no significant association between alcohol drinking and an increased pancreatic cancer risk, even at high levels of alcohol consumption. Even among those genetically susceptible to the carcinogenic effect of alcohol (carriers of ADH1B2/2(fast activity) combined with ALDH21/2(slow activity) or ALDH22/2(almost non-functional)), no significant association between alcohol use and pancreatic cancer was observed. Overall, our results suggested that alcohol drinking is not a significant contributor to the occurrence of pancreatic cancer in Taiwan.Yan-Shen ShanLi-Tzong ChenChih-Hsing WuYin-Fan ChangChih-Ting LeeNai-Jung ChiangYing-Jui ChaoChia-Jui YenHui-Jen TsaiHsin-En HuangChia-Rung TsaiYa-Ling WengHan-Chien YangHui-Chin LiuJeffrey S. ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan-Shen Shan Li-Tzong Chen Chih-Hsing Wu Yin-Fan Chang Chih-Ting Lee Nai-Jung Chiang Ying-Jui Chao Chia-Jui Yen Hui-Jen Tsai Hsin-En Huang Chia-Rung Tsai Ya-Ling Weng Han-Chien Yang Hui-Chin Liu Jeffrey S. Chang No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol
description	Abstract Inconsistent results have been reported for the association between alcohol use and pancreatic cancer, particularly at low levels of alcohol consumption. Individuals genetically susceptible to the carcinogenic effect of alcohol might have higher pancreatic cancer risk after drinking alcohol. The current study investigated the association between alcohol use and pancreatic cancer with 419 pancreatic cancer cases and 963 controls recruited by a hospital-based case–control study in Taiwan. Gene-environment interaction between alcohol use and polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on pancreatic risk was evaluated. Our results showed no significant association between alcohol drinking and an increased pancreatic cancer risk, even at high levels of alcohol consumption. Even among those genetically susceptible to the carcinogenic effect of alcohol (carriers of ADH1B2/2(fast activity) combined with ALDH21/2(slow activity) or ALDH22/2(almost non-functional)), no significant association between alcohol use and pancreatic cancer was observed. Overall, our results suggested that alcohol drinking is not a significant contributor to the occurrence of pancreatic cancer in Taiwan.
format	article
author	Yan-Shen Shan Li-Tzong Chen Chih-Hsing Wu Yin-Fan Chang Chih-Ting Lee Nai-Jung Chiang Ying-Jui Chao Chia-Jui Yen Hui-Jen Tsai Hsin-En Huang Chia-Rung Tsai Ya-Ling Weng Han-Chien Yang Hui-Chin Liu Jeffrey S. Chang
author_facet	Yan-Shen Shan Li-Tzong Chen Chih-Hsing Wu Yin-Fan Chang Chih-Ting Lee Nai-Jung Chiang Ying-Jui Chao Chia-Jui Yen Hui-Jen Tsai Hsin-En Huang Chia-Rung Tsai Ya-Ling Weng Han-Chien Yang Hui-Chin Liu Jeffrey S. Chang
author_sort	Yan-Shen Shan
title	No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol
title_short	No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol
title_full	No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol
title_fullStr	No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol
title_full_unstemmed	No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol
title_sort	no association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/84b4b726eb174a59ad94d3a3577f65f1
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No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol

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