Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

The genomic characterisation of nasopharyngeal carcinoma (NPC) remains crucial. Here, the authors perform whole-genome sequencing for 70 NPCs with EBV gene expression, report the somatic alterations and EBV-mediated effects converging on NF-κB activation and immune escape and identify targetable hom...

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Autores principales:	Jeff P. Bruce, Ka-Fai To, Vivian W. Y. Lui, Grace T. Y. Chung, Yuk-Yu Chan, Chi Man Tsang, Kevin Y. Yip, Brigette B. Y. Ma, John K. S. Woo, Edwin P. Hui, Michael K. F. Mak, Sau-Dan Lee, Chit Chow, Sharmila Velapasamy, Yvonne Y. Y. Or, Pui Kei Siu, Samah El Ghamrasni, Stephenie Prokopec, Man Wu, Johnny S. H. Kwan, Yuchen Liu, Jason Y. K. Chan, C. Andrew van Hasselt, Lawrence S. Young, Christopher W. Dawson, Ian C. Paterson, Lee-Fah Yap, Sai-Wah Tsao, Fei-Fei Liu, Anthony T. C. Chan, Trevor J. Pugh, Kwok-Wai Lo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84b65b92c11446b886dec64811b68199
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spelling	oai:doaj.org-article:84b65b92c11446b886dec64811b681992021-12-02T18:34:21ZWhole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape10.1038/s41467-021-24348-62041-1723https://doaj.org/article/84b65b92c11446b886dec64811b681992021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24348-6https://doaj.org/toc/2041-1723The genomic characterisation of nasopharyngeal carcinoma (NPC) remains crucial. Here, the authors perform whole-genome sequencing for 70 NPCs with EBV gene expression, report the somatic alterations and EBV-mediated effects converging on NF-κB activation and immune escape and identify targetable homozygous MTAP deletions.Jeff P. BruceKa-Fai ToVivian W. Y. LuiGrace T. Y. ChungYuk-Yu ChanChi Man TsangKevin Y. YipBrigette B. Y. MaJohn K. S. WooEdwin P. HuiMichael K. F. MakSau-Dan LeeChit ChowSharmila VelapasamyYvonne Y. Y. OrPui Kei SiuSamah El GhamrasniStephenie ProkopecMan WuJohnny S. H. KwanYuchen LiuJason Y. K. ChanC. Andrew van HasseltLawrence S. YoungChristopher W. DawsonIan C. PatersonLee-Fah YapSai-Wah TsaoFei-Fei LiuAnthony T. C. ChanTrevor J. PughKwok-Wai LoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeff P. Bruce Ka-Fai To Vivian W. Y. Lui Grace T. Y. Chung Yuk-Yu Chan Chi Man Tsang Kevin Y. Yip Brigette B. Y. Ma John K. S. Woo Edwin P. Hui Michael K. F. Mak Sau-Dan Lee Chit Chow Sharmila Velapasamy Yvonne Y. Y. Or Pui Kei Siu Samah El Ghamrasni Stephenie Prokopec Man Wu Johnny S. H. Kwan Yuchen Liu Jason Y. K. Chan C. Andrew van Hasselt Lawrence S. Young Christopher W. Dawson Ian C. Paterson Lee-Fah Yap Sai-Wah Tsao Fei-Fei Liu Anthony T. C. Chan Trevor J. Pugh Kwok-Wai Lo Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape
description	The genomic characterisation of nasopharyngeal carcinoma (NPC) remains crucial. Here, the authors perform whole-genome sequencing for 70 NPCs with EBV gene expression, report the somatic alterations and EBV-mediated effects converging on NF-κB activation and immune escape and identify targetable homozygous MTAP deletions.
format	article
author	Jeff P. Bruce Ka-Fai To Vivian W. Y. Lui Grace T. Y. Chung Yuk-Yu Chan Chi Man Tsang Kevin Y. Yip Brigette B. Y. Ma John K. S. Woo Edwin P. Hui Michael K. F. Mak Sau-Dan Lee Chit Chow Sharmila Velapasamy Yvonne Y. Y. Or Pui Kei Siu Samah El Ghamrasni Stephenie Prokopec Man Wu Johnny S. H. Kwan Yuchen Liu Jason Y. K. Chan C. Andrew van Hasselt Lawrence S. Young Christopher W. Dawson Ian C. Paterson Lee-Fah Yap Sai-Wah Tsao Fei-Fei Liu Anthony T. C. Chan Trevor J. Pugh Kwok-Wai Lo
author_facet	Jeff P. Bruce Ka-Fai To Vivian W. Y. Lui Grace T. Y. Chung Yuk-Yu Chan Chi Man Tsang Kevin Y. Yip Brigette B. Y. Ma John K. S. Woo Edwin P. Hui Michael K. F. Mak Sau-Dan Lee Chit Chow Sharmila Velapasamy Yvonne Y. Y. Or Pui Kei Siu Samah El Ghamrasni Stephenie Prokopec Man Wu Johnny S. H. Kwan Yuchen Liu Jason Y. K. Chan C. Andrew van Hasselt Lawrence S. Young Christopher W. Dawson Ian C. Paterson Lee-Fah Yap Sai-Wah Tsao Fei-Fei Liu Anthony T. C. Chan Trevor J. Pugh Kwok-Wai Lo
author_sort	Jeff P. Bruce
title	Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape
title_short	Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape
title_full	Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape
title_fullStr	Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape
title_full_unstemmed	Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape
title_sort	whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory nf-κb activation and immune escape
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/84b65b92c11446b886dec64811b68199
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Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

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