Inflammatory mediators: Parallels between cancer biology and stem cell therapy

Shyam A Patel1,2,3, Andrew C Heinrich2,3, Bobby Y Reddy2, Pranela Rameshwar21Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA; 2Department of Medicine &ndash; Division of Hematology/Oncology, New Jersey Medical School, University of...

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Autores principales:	A Patel, Andrew C Heinrich, Bobby Y Reddy, Pranela Rameshwar
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/84b6a2b1b3f142d39540f5072eb3ef3a
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spelling	oai:doaj.org-article:84b6a2b1b3f142d39540f5072eb3ef3a2021-12-02T06:10:22ZInflammatory mediators: Parallels between cancer biology and stem cell therapy1178-7031https://doaj.org/article/84b6a2b1b3f142d39540f5072eb3ef3a2009-02-01T00:00:00Zhttp://www.dovepress.com/inflammatory-mediators-parallels-between-cancer-biology-and-stem-cell--a2845https://doaj.org/toc/1178-7031Shyam A Patel1,2,3, Andrew C Heinrich2,3, Bobby Y Reddy2, Pranela Rameshwar21Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA; 2Department of Medicine &ndash; Division of Hematology/Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA; 3These authors contributed equally to this workAbstract: Inflammation encompasses diverse molecular pathways, and it is intertwined with a wide array of biological processes. Recently, there has been an upsurge of interest in the interactions between mediators of inflammation and other cells such as stem cells and cancer cells. Since tissue injuries are associated with the release of inflammatory mediators, it would be difficult to address this subject without considering the implications of their systemic effects. In this review, we discuss the effects of inflammatory reactions on stem cells and extrapolate on information pertaining to cancer biology. The discussion focuses on integrins and cytokines, and identifies the transcription factor, nuclear factor-kappa B (NF&kappa;B) as central to the inflammatory response. Since stem cell therapy has been proposed for type II diabetes mellitus, metabolic syndrome, pulmonary edema, these disorders are used as examples to discuss the roles of inflammatory mediators. We propose prospects for future research on targeting the NF&kappa;B signaling pathway. Finally, we explore the bridge between inflammation and stem cells, including neural stem cells and adult stem cells from the bone marrow. The implications of mesenchymal stem cells in regenerative medicine as pertaining to inflammation are vast based on their anti-inflammatory and immunosuppressive effects. Such features of stem cells offer great potential for therapy in graft-versus-host disease, conditions with a significant inflammatory component, and tissue regeneration.Keywords: mesenchymal stem cells, cancer, cytokines, NF kappa B A PatelAndrew C HeinrichBobby Y ReddyPranela RameshwarDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2009, Iss default, Pp 13-19 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 A Patel Andrew C Heinrich Bobby Y Reddy Pranela Rameshwar Inflammatory mediators: Parallels between cancer biology and stem cell therapy
description	Shyam A Patel1,2,3, Andrew C Heinrich2,3, Bobby Y Reddy2, Pranela Rameshwar21Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA; 2Department of Medicine &ndash; Division of Hematology/Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA; 3These authors contributed equally to this workAbstract: Inflammation encompasses diverse molecular pathways, and it is intertwined with a wide array of biological processes. Recently, there has been an upsurge of interest in the interactions between mediators of inflammation and other cells such as stem cells and cancer cells. Since tissue injuries are associated with the release of inflammatory mediators, it would be difficult to address this subject without considering the implications of their systemic effects. In this review, we discuss the effects of inflammatory reactions on stem cells and extrapolate on information pertaining to cancer biology. The discussion focuses on integrins and cytokines, and identifies the transcription factor, nuclear factor-kappa B (NF&kappa;B) as central to the inflammatory response. Since stem cell therapy has been proposed for type II diabetes mellitus, metabolic syndrome, pulmonary edema, these disorders are used as examples to discuss the roles of inflammatory mediators. We propose prospects for future research on targeting the NF&kappa;B signaling pathway. Finally, we explore the bridge between inflammation and stem cells, including neural stem cells and adult stem cells from the bone marrow. The implications of mesenchymal stem cells in regenerative medicine as pertaining to inflammation are vast based on their anti-inflammatory and immunosuppressive effects. Such features of stem cells offer great potential for therapy in graft-versus-host disease, conditions with a significant inflammatory component, and tissue regeneration.Keywords: mesenchymal stem cells, cancer, cytokines, NF kappa B
format	article
author	A Patel Andrew C Heinrich Bobby Y Reddy Pranela Rameshwar
author_facet	A Patel Andrew C Heinrich Bobby Y Reddy Pranela Rameshwar
author_sort	A Patel
title	Inflammatory mediators: Parallels between cancer biology and stem cell therapy
title_short	Inflammatory mediators: Parallels between cancer biology and stem cell therapy
title_full	Inflammatory mediators: Parallels between cancer biology and stem cell therapy
title_fullStr	Inflammatory mediators: Parallels between cancer biology and stem cell therapy
title_full_unstemmed	Inflammatory mediators: Parallels between cancer biology and stem cell therapy
title_sort	inflammatory mediators: parallels between cancer biology and stem cell therapy
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/84b6a2b1b3f142d39540f5072eb3ef3a
work_keys_str_mv	AT apatel inflammatorymediatorsparallelsbetweencancerbiologyandstemcelltherapy AT andrewcheinrich inflammatorymediatorsparallelsbetweencancerbiologyandstemcelltherapy AT bobbyyreddy inflammatorymediatorsparallelsbetweencancerbiologyandstemcelltherapy AT pranelarameshwar inflammatorymediatorsparallelsbetweencancerbiologyandstemcelltherapy
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Inflammatory mediators: Parallels between cancer biology and stem cell therapy

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