Distinct epigenetic signatures between adult-onset and late-onset depression
Abstract The heterogeneity of major depressive disorder (MDD) is attributed to the fact that diagnostic criteria (e.g., DSM-5) are only based on clinical symptoms. The discovery of blood biomarkers has the potential to change the diagnosis of MDD. The purpose of this study was to identify blood biom...
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2021
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oai:doaj.org-article:84b8df44d1fd4515b91b2bc9e4e3a7f32021-12-02T13:57:25ZDistinct epigenetic signatures between adult-onset and late-onset depression10.1038/s41598-021-81758-82045-2322https://doaj.org/article/84b8df44d1fd4515b91b2bc9e4e3a7f32021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81758-8https://doaj.org/toc/2045-2322Abstract The heterogeneity of major depressive disorder (MDD) is attributed to the fact that diagnostic criteria (e.g., DSM-5) are only based on clinical symptoms. The discovery of blood biomarkers has the potential to change the diagnosis of MDD. The purpose of this study was to identify blood biomarkers of DNA methylation by strategically subtyping patients with MDD by onset age. We analyzed genome-wide DNA methylation of patients with adult-onset depression (AOD; age ≥ 50 years, age at depression onset < 50 years; N = 10) and late-onset depression (LOD; age ≥ 50 years, age at depression onset ≥ 50 years; N = 25) in comparison to that of 30 healthy subjects. The methylation profile of the AOD group was not only different from that of the LOD group but also more homogenous. Six identified methylation CpG sites were validated by pyrosequencing and amplicon bisulfite sequencing as potential markers for AOD in a second set of independent patients with AOD and healthy control subjects (N = 11). The combination of three specific methylation markers achieved the highest accuracy (sensitivity, 64%; specificity, 91%; accuracy, 77%). Taken together, our findings suggest that DNA methylation markers are more suitable for AOD than for LOD patients.Hirotaka YamagataHiroyuki OgiharaKoji MatsuoShusaku UchidaAyumi KobayashiTomoe SekiMasaaki KobayashiKenichiro HaradaChong ChenShigeo MiyataMasato FukudaMasahiko MikuniYoshihiko HamamotoYoshifumi WatanabeShin NakagawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Hirotaka Yamagata Hiroyuki Ogihara Koji Matsuo Shusaku Uchida Ayumi Kobayashi Tomoe Seki Masaaki Kobayashi Kenichiro Harada Chong Chen Shigeo Miyata Masato Fukuda Masahiko Mikuni Yoshihiko Hamamoto Yoshifumi Watanabe Shin Nakagawa Distinct epigenetic signatures between adult-onset and late-onset depression |
| description |
Abstract The heterogeneity of major depressive disorder (MDD) is attributed to the fact that diagnostic criteria (e.g., DSM-5) are only based on clinical symptoms. The discovery of blood biomarkers has the potential to change the diagnosis of MDD. The purpose of this study was to identify blood biomarkers of DNA methylation by strategically subtyping patients with MDD by onset age. We analyzed genome-wide DNA methylation of patients with adult-onset depression (AOD; age ≥ 50 years, age at depression onset < 50 years; N = 10) and late-onset depression (LOD; age ≥ 50 years, age at depression onset ≥ 50 years; N = 25) in comparison to that of 30 healthy subjects. The methylation profile of the AOD group was not only different from that of the LOD group but also more homogenous. Six identified methylation CpG sites were validated by pyrosequencing and amplicon bisulfite sequencing as potential markers for AOD in a second set of independent patients with AOD and healthy control subjects (N = 11). The combination of three specific methylation markers achieved the highest accuracy (sensitivity, 64%; specificity, 91%; accuracy, 77%). Taken together, our findings suggest that DNA methylation markers are more suitable for AOD than for LOD patients. |
| format |
article |
| author |
Hirotaka Yamagata Hiroyuki Ogihara Koji Matsuo Shusaku Uchida Ayumi Kobayashi Tomoe Seki Masaaki Kobayashi Kenichiro Harada Chong Chen Shigeo Miyata Masato Fukuda Masahiko Mikuni Yoshihiko Hamamoto Yoshifumi Watanabe Shin Nakagawa |
| author_facet |
Hirotaka Yamagata Hiroyuki Ogihara Koji Matsuo Shusaku Uchida Ayumi Kobayashi Tomoe Seki Masaaki Kobayashi Kenichiro Harada Chong Chen Shigeo Miyata Masato Fukuda Masahiko Mikuni Yoshihiko Hamamoto Yoshifumi Watanabe Shin Nakagawa |
| author_sort |
Hirotaka Yamagata |
| title |
Distinct epigenetic signatures between adult-onset and late-onset depression |
| title_short |
Distinct epigenetic signatures between adult-onset and late-onset depression |
| title_full |
Distinct epigenetic signatures between adult-onset and late-onset depression |
| title_fullStr |
Distinct epigenetic signatures between adult-onset and late-onset depression |
| title_full_unstemmed |
Distinct epigenetic signatures between adult-onset and late-onset depression |
| title_sort |
distinct epigenetic signatures between adult-onset and late-onset depression |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/84b8df44d1fd4515b91b2bc9e4e3a7f3 |
| work_keys_str_mv |
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1718392332382896128 |