A scoring system to detect fixed airflow limitation in smokers from simple easy-to-use parameters

Abstract No validated screening method currently exists for Chronic Obstructive Pulmonary Disease (COPD) in smokers. Therefore, we constructed a predictive model with simple parameters that can be applied for COPD screening to detect fixed airflow limitation. This observational cross-sectional study...

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Autores principales:	Esther Román-Conejos, Antonio Palazón-Bru, David Manuel Folgado-de la Rosa, Manuel Sánchez-Molla, María Mercedes Rizo-Baeza, Vicente Francisco Gil-Guillén, Ernesto Cortés-Castell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84ba290c4ff84dff8866cb7b7c0fd138
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spelling	oai:doaj.org-article:84ba290c4ff84dff8866cb7b7c0fd1382021-12-02T15:09:07ZA scoring system to detect fixed airflow limitation in smokers from simple easy-to-use parameters10.1038/s41598-018-31198-82045-2322https://doaj.org/article/84ba290c4ff84dff8866cb7b7c0fd1382018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31198-8https://doaj.org/toc/2045-2322Abstract No validated screening method currently exists for Chronic Obstructive Pulmonary Disease (COPD) in smokers. Therefore, we constructed a predictive model with simple parameters that can be applied for COPD screening to detect fixed airflow limitation. This observational cross-sectional study included a random sample of 222 smokers with no previous diagnosis of COPD undertaken in a Spanish region in 2014–2016. The main variable was fixed airflow limitation by spirometry. The secondary variables (COPD factors) were: age, gender, smoking (pack-years and Fagerström test), body mass index, educational level, respiratory symptoms and exacerbations. A points system was developed to predict fixed airflow limitation based on secondary variables. The model was validated internally through bootstrapping, determining discrimination and calibration. The system was then integrated into a mobile application for Android. Fifty-seven patients (25.7%) presented fixed airflow limitation. The points system included as predictors: age, pack-years, Fagerström test and presence of respiratory symptoms. Internal validation of the system was very satisfactory, both in discrimination and calibration. In conclusion, a points system has been constructed to predict fixed airflow limitation in smokers with no previous COPD. This system can be integrated as a screening tool, though it should be externally validated in other geographical regions.Esther Román-ConejosAntonio Palazón-BruDavid Manuel Folgado-de la RosaManuel Sánchez-MollaMaría Mercedes Rizo-BaezaVicente Francisco Gil-GuillénErnesto Cortés-CastellNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Esther Román-Conejos Antonio Palazón-Bru David Manuel Folgado-de la Rosa Manuel Sánchez-Molla María Mercedes Rizo-Baeza Vicente Francisco Gil-Guillén Ernesto Cortés-Castell A scoring system to detect fixed airflow limitation in smokers from simple easy-to-use parameters
description	Abstract No validated screening method currently exists for Chronic Obstructive Pulmonary Disease (COPD) in smokers. Therefore, we constructed a predictive model with simple parameters that can be applied for COPD screening to detect fixed airflow limitation. This observational cross-sectional study included a random sample of 222 smokers with no previous diagnosis of COPD undertaken in a Spanish region in 2014–2016. The main variable was fixed airflow limitation by spirometry. The secondary variables (COPD factors) were: age, gender, smoking (pack-years and Fagerström test), body mass index, educational level, respiratory symptoms and exacerbations. A points system was developed to predict fixed airflow limitation based on secondary variables. The model was validated internally through bootstrapping, determining discrimination and calibration. The system was then integrated into a mobile application for Android. Fifty-seven patients (25.7%) presented fixed airflow limitation. The points system included as predictors: age, pack-years, Fagerström test and presence of respiratory symptoms. Internal validation of the system was very satisfactory, both in discrimination and calibration. In conclusion, a points system has been constructed to predict fixed airflow limitation in smokers with no previous COPD. This system can be integrated as a screening tool, though it should be externally validated in other geographical regions.
format	article
author	Esther Román-Conejos Antonio Palazón-Bru David Manuel Folgado-de la Rosa Manuel Sánchez-Molla María Mercedes Rizo-Baeza Vicente Francisco Gil-Guillén Ernesto Cortés-Castell
author_facet	Esther Román-Conejos Antonio Palazón-Bru David Manuel Folgado-de la Rosa Manuel Sánchez-Molla María Mercedes Rizo-Baeza Vicente Francisco Gil-Guillén Ernesto Cortés-Castell
author_sort	Esther Román-Conejos
title	A scoring system to detect fixed airflow limitation in smokers from simple easy-to-use parameters
title_short	A scoring system to detect fixed airflow limitation in smokers from simple easy-to-use parameters
title_full	A scoring system to detect fixed airflow limitation in smokers from simple easy-to-use parameters
title_fullStr	A scoring system to detect fixed airflow limitation in smokers from simple easy-to-use parameters
title_full_unstemmed	A scoring system to detect fixed airflow limitation in smokers from simple easy-to-use parameters
title_sort	scoring system to detect fixed airflow limitation in smokers from simple easy-to-use parameters
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/84ba290c4ff84dff8866cb7b7c0fd138
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A scoring system to detect fixed airflow limitation in smokers from simple easy-to-use parameters

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