Growth-profile configuration for specific deformations of tubular organs: A study of growth-induced thinning and dilation of the human cervix.

Growth is a significant factor that results in deformations of tubular organs, and particular deformations associated with growth enable tubular organs to perform certain physiological functions. Configuring growth profiles that achieve particular deformation patterns is critical for analyzing poten...

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Autores principales:	Kun Gou, Seungik Baek, Marvin M F Lutnesky, Hai-Chao Han
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84bf3007adaf4e5b88c5d93fc637380c
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spelling	oai:doaj.org-article:84bf3007adaf4e5b88c5d93fc637380c2021-12-02T20:18:24ZGrowth-profile configuration for specific deformations of tubular organs: A study of growth-induced thinning and dilation of the human cervix.1932-620310.1371/journal.pone.0255895https://doaj.org/article/84bf3007adaf4e5b88c5d93fc637380c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255895https://doaj.org/toc/1932-6203Growth is a significant factor that results in deformations of tubular organs, and particular deformations associated with growth enable tubular organs to perform certain physiological functions. Configuring growth profiles that achieve particular deformation patterns is critical for analyzing potential pathological conditions and for developing corresponding clinical treatments for tubular organ dysfunctions. However, deformation-targeted growth is rarely studied. In this article, the human cervix during pregnancy is studied as an example to show how cervical thinning and dilation are generated by growth. An advanced hyperelasticity theory called morphoelasticity is employed to model the deformations, and a growth tensor is used to represent growth in three principle directions. The computational results demonstrate that both negative radial growth and positive circumferential growth facilitate thinning and dilation. Modeling such mixed growth represents an advancement beyond commonly used uniform growth inside tissues to study tubular deformations. The results reveal that complex growth may occur inside tissues to achieve certain tubular deformations. Integration of further biochemical and cellular activities that initiate and mediate such complex growth remains to be explored.Kun GouSeungik BaekMarvin M F LutneskyHai-Chao HanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255895 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kun Gou Seungik Baek Marvin M F Lutnesky Hai-Chao Han Growth-profile configuration for specific deformations of tubular organs: A study of growth-induced thinning and dilation of the human cervix.
description	Growth is a significant factor that results in deformations of tubular organs, and particular deformations associated with growth enable tubular organs to perform certain physiological functions. Configuring growth profiles that achieve particular deformation patterns is critical for analyzing potential pathological conditions and for developing corresponding clinical treatments for tubular organ dysfunctions. However, deformation-targeted growth is rarely studied. In this article, the human cervix during pregnancy is studied as an example to show how cervical thinning and dilation are generated by growth. An advanced hyperelasticity theory called morphoelasticity is employed to model the deformations, and a growth tensor is used to represent growth in three principle directions. The computational results demonstrate that both negative radial growth and positive circumferential growth facilitate thinning and dilation. Modeling such mixed growth represents an advancement beyond commonly used uniform growth inside tissues to study tubular deformations. The results reveal that complex growth may occur inside tissues to achieve certain tubular deformations. Integration of further biochemical and cellular activities that initiate and mediate such complex growth remains to be explored.
format	article
author	Kun Gou Seungik Baek Marvin M F Lutnesky Hai-Chao Han
author_facet	Kun Gou Seungik Baek Marvin M F Lutnesky Hai-Chao Han
author_sort	Kun Gou
title	Growth-profile configuration for specific deformations of tubular organs: A study of growth-induced thinning and dilation of the human cervix.
title_short	Growth-profile configuration for specific deformations of tubular organs: A study of growth-induced thinning and dilation of the human cervix.
title_full	Growth-profile configuration for specific deformations of tubular organs: A study of growth-induced thinning and dilation of the human cervix.
title_fullStr	Growth-profile configuration for specific deformations of tubular organs: A study of growth-induced thinning and dilation of the human cervix.
title_full_unstemmed	Growth-profile configuration for specific deformations of tubular organs: A study of growth-induced thinning and dilation of the human cervix.
title_sort	growth-profile configuration for specific deformations of tubular organs: a study of growth-induced thinning and dilation of the human cervix.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/84bf3007adaf4e5b88c5d93fc637380c
work_keys_str_mv	AT kungou growthprofileconfigurationforspecificdeformationsoftubularorgansastudyofgrowthinducedthinninganddilationofthehumancervix AT seungikbaek growthprofileconfigurationforspecificdeformationsoftubularorgansastudyofgrowthinducedthinninganddilationofthehumancervix AT marvinmflutnesky growthprofileconfigurationforspecificdeformationsoftubularorgansastudyofgrowthinducedthinninganddilationofthehumancervix AT haichaohan growthprofileconfigurationforspecificdeformationsoftubularorgansastudyofgrowthinducedthinninganddilationofthehumancervix
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Growth-profile configuration for specific deformations of tubular organs: A study of growth-induced thinning and dilation of the human cervix.

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