Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity

Mohyeddin Assali,1 Abdel Naser Zaid,1 Farah Abdallah,1 Motasem Almasri,2 Rasha Khayyat3 1Department of Pharmacy, Faculty of Medicine and Health Sciences, An Najah National University, Nablus, Palestine; 2Department of Biology and Biotechnology, Faculty of Science, An Najah Nationa...

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Autores principales:	Assali M, Zaid AN, Abdallah F, Almasri M, Khayyat R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Covalent functionalization hydrophilic/hydrophobic balance carbon nanotubes nanoantibiotic. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/84bf7dbb677c45e5a41479112c9fa817
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spelling	oai:doaj.org-article:84bf7dbb677c45e5a41479112c9fa8172021-12-02T02:37:16ZSingle-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity1178-2013https://doaj.org/article/84bf7dbb677c45e5a41479112c9fa8172017-09-01T00:00:00Zhttps://www.dovepress.com/single-walled-carbon-nanotubes-ciprofloxacin-nanoantibiotic-strategy-t-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mohyeddin Assali,1 Abdel Naser Zaid,1 Farah Abdallah,1 Motasem Almasri,2 Rasha Khayyat3 1Department of Pharmacy, Faculty of Medicine and Health Sciences, An Najah National University, Nablus, Palestine; 2Department of Biology and Biotechnology, Faculty of Science, An Najah National University, Nablus, Palestine; 3Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An Najah National University, Nablus, Palestine Abstract: As infectious diseases continue to be one of the greatest health challenges worldwide, the demand toward alternative agents is continuously increasing. Recent advancement in nanotechnology has expanded our ability to design and construct nanomaterials to treat bacterial infections. Carbon nanotubes are one among these nanomaterials. Herein, we describe the covalent functionalization of the single-walled carbon nanotubes (SWCNTs) with multiple molecules of ciprofloxacin. The prepared nanoantibiotics were characterized using different techniques, including transmission electron microscopy, Raman spectroscopy, and thermogravimetric analysis. The characterization of the nanoantibiotics confirmed the successful covalent functionalization of the SWCNTs with 55% of functionalization as has been observed by thermogravimetric analysis. The release profile revealed that 90% of the loaded ciprofloxacin was released within 2.5 h at pH 7.4 showing a first-order release profile with R2>0.99. Interestingly, the results of the antibacterial activity indicated that the functionalized SWCNTs have significant increase in the antibacterial activity against the three strains of bacteria – by 16-fold for Staphylococcus aureus and Pseudomonas aeruginosa and by 8-fold for Escherichia coli – in comparison to the ciprofloxacin free drug. Moreover, the synthesized nanoantibiotic showed high hemocompatibility and cytocompatibility over a wide concentration range. Keywords: covalent functionalization, hydrophilic/hydrophobic balance, carbon nanotubes, nanoantibiotic Assali MZaid ANAbdallah FAlmasri MKhayyat RDove Medical PressarticleCovalent functionalizationhydrophilic/hydrophobic balancecarbon nanotubesnanoantibiotic.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6647-6659 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Covalent functionalization hydrophilic/hydrophobic balance carbon nanotubes nanoantibiotic. Medicine (General) R5-920
spellingShingle	Covalent functionalization hydrophilic/hydrophobic balance carbon nanotubes nanoantibiotic. Medicine (General) R5-920 Assali M Zaid AN Abdallah F Almasri M Khayyat R Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity
description	Mohyeddin Assali,1 Abdel Naser Zaid,1 Farah Abdallah,1 Motasem Almasri,2 Rasha Khayyat3 1Department of Pharmacy, Faculty of Medicine and Health Sciences, An Najah National University, Nablus, Palestine; 2Department of Biology and Biotechnology, Faculty of Science, An Najah National University, Nablus, Palestine; 3Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An Najah National University, Nablus, Palestine Abstract: As infectious diseases continue to be one of the greatest health challenges worldwide, the demand toward alternative agents is continuously increasing. Recent advancement in nanotechnology has expanded our ability to design and construct nanomaterials to treat bacterial infections. Carbon nanotubes are one among these nanomaterials. Herein, we describe the covalent functionalization of the single-walled carbon nanotubes (SWCNTs) with multiple molecules of ciprofloxacin. The prepared nanoantibiotics were characterized using different techniques, including transmission electron microscopy, Raman spectroscopy, and thermogravimetric analysis. The characterization of the nanoantibiotics confirmed the successful covalent functionalization of the SWCNTs with 55% of functionalization as has been observed by thermogravimetric analysis. The release profile revealed that 90% of the loaded ciprofloxacin was released within 2.5 h at pH 7.4 showing a first-order release profile with R2>0.99. Interestingly, the results of the antibacterial activity indicated that the functionalized SWCNTs have significant increase in the antibacterial activity against the three strains of bacteria – by 16-fold for Staphylococcus aureus and Pseudomonas aeruginosa and by 8-fold for Escherichia coli – in comparison to the ciprofloxacin free drug. Moreover, the synthesized nanoantibiotic showed high hemocompatibility and cytocompatibility over a wide concentration range. Keywords: covalent functionalization, hydrophilic/hydrophobic balance, carbon nanotubes, nanoantibiotic
format	article
author	Assali M Zaid AN Abdallah F Almasri M Khayyat R
author_facet	Assali M Zaid AN Abdallah F Almasri M Khayyat R
author_sort	Assali M
title	Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity
title_short	Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity
title_full	Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity
title_fullStr	Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity
title_full_unstemmed	Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity
title_sort	single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/84bf7dbb677c45e5a41479112c9fa817
work_keys_str_mv	AT assalim singlewalledcarbonnanotubesciprofloxacinnanoantibioticstrategytoimproveciprofloxacinantibacterialactivity AT zaidan singlewalledcarbonnanotubesciprofloxacinnanoantibioticstrategytoimproveciprofloxacinantibacterialactivity AT abdallahf singlewalledcarbonnanotubesciprofloxacinnanoantibioticstrategytoimproveciprofloxacinantibacterialactivity AT almasrim singlewalledcarbonnanotubesciprofloxacinnanoantibioticstrategytoimproveciprofloxacinantibacterialactivity AT khayyatr singlewalledcarbonnanotubesciprofloxacinnanoantibioticstrategytoimproveciprofloxacinantibacterialactivity
_version_	1718402299851702272

Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity

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