Positioning Aeromonas Infection in Inflammatory Bowel Disease: A Retrospective Analysis

Background and Aim: Aeromonas are Gram-negative rods known to cause a spectrum of diseases. Inflammatory bowel disease (IBD) is an idiopathic complex condition resulting from interaction of multiple factors. Aeromonas infection in association with IBD is still largely unknown. We aim to look for the...

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Autores principales:	Tiago Pereira Guedes, Joana Alves Silva, Sara Neves, Daniela Falcão, Paula Costa, Paula Lago, Isabel Pedroto, Marta Salgado
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	aeromonas inflammatory bowel disease crohn’s disease ulcerative colitis gi infections immunology microbiology and inflammatory bowel disease Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/84bf928d3a8b4d2787ad7a4fa4c656ea
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spelling	oai:doaj.org-article:84bf928d3a8b4d2787ad7a4fa4c656ea2021-12-02T12:40:23ZPositioning Aeromonas Infection in Inflammatory Bowel Disease: A Retrospective Analysis2341-45452387-195410.1159/000520272https://doaj.org/article/84bf928d3a8b4d2787ad7a4fa4c656ea2021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520272https://doaj.org/toc/2341-4545https://doaj.org/toc/2387-1954Background and Aim: Aeromonas are Gram-negative rods known to cause a spectrum of diseases. Inflammatory bowel disease (IBD) is an idiopathic complex condition resulting from interaction of multiple factors. Aeromonas infection in association with IBD is still largely unknown. We aim to look for the significance of Aeromonas infection and for significant differences between IBD and non-IBD patients. Methods: A retrospective observational analysis was performed of all patients positive for Aeromonas in stool cultures, during a 10-year period, from a tertiary and university hospital. Results: Fifty patients were included, 56% male with a mean age of 42.1 years. Thirty-eight (76%) were non-IBD and 12 (24%) IBD patients. IBD patients were more frequently under immunosuppressors. Two patients were asymptomatic and 44% developed mild, 44% moderate, and 16.7% severe infection. The main strains isolated were Aeromonas hydrophila/caviae. Bacterial co-isolation was found in 4 non-IBD and histological findings of cytomegalovirus in 2 IBD patients. Non-IBD patients presented more frequently with fever and IBD patients with bloody diarrhea and abdominal pain. There was higher tendency for severe infection rate in IBD patients with higher antimicrobial therapy use. Steroids were exclusively used in the IBD group. From IBD, 4 patients had the diagnosis of ulcerative colitis and 9 of Crohn’s disease with colonic involvement. Of these patients, 5 received IBD diagnosis after the acute episode of Aeromonas infection. Conclusions: Clinical presentation of Aeromonas infection differs between IBD and non-IBD patients. Non-IBD patients had milder severity of infection with less use of antibiotics. Aeromonas infection seems to greatly contribute to IBD manifestation.Tiago Pereira GuedesJoana Alves SilvaSara NevesDaniela FalcãoPaula CostaPaula LagoIsabel PedrotoMarta SalgadoKarger Publishersarticleaeromonasinflammatory bowel diseasecrohn’s diseaseulcerative colitisgi infectionsimmunologymicrobiology and inflammatory bowel diseaseDiseases of the digestive system. GastroenterologyRC799-869ENGE: Portuguese Journal of Gastroenterology, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aeromonas inflammatory bowel disease crohn’s disease ulcerative colitis gi infections immunology microbiology and inflammatory bowel disease Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	aeromonas inflammatory bowel disease crohn’s disease ulcerative colitis gi infections immunology microbiology and inflammatory bowel disease Diseases of the digestive system. Gastroenterology RC799-869 Tiago Pereira Guedes Joana Alves Silva Sara Neves Daniela Falcão Paula Costa Paula Lago Isabel Pedroto Marta Salgado Positioning Aeromonas Infection in Inflammatory Bowel Disease: A Retrospective Analysis
description	Background and Aim: Aeromonas are Gram-negative rods known to cause a spectrum of diseases. Inflammatory bowel disease (IBD) is an idiopathic complex condition resulting from interaction of multiple factors. Aeromonas infection in association with IBD is still largely unknown. We aim to look for the significance of Aeromonas infection and for significant differences between IBD and non-IBD patients. Methods: A retrospective observational analysis was performed of all patients positive for Aeromonas in stool cultures, during a 10-year period, from a tertiary and university hospital. Results: Fifty patients were included, 56% male with a mean age of 42.1 years. Thirty-eight (76%) were non-IBD and 12 (24%) IBD patients. IBD patients were more frequently under immunosuppressors. Two patients were asymptomatic and 44% developed mild, 44% moderate, and 16.7% severe infection. The main strains isolated were Aeromonas hydrophila/caviae. Bacterial co-isolation was found in 4 non-IBD and histological findings of cytomegalovirus in 2 IBD patients. Non-IBD patients presented more frequently with fever and IBD patients with bloody diarrhea and abdominal pain. There was higher tendency for severe infection rate in IBD patients with higher antimicrobial therapy use. Steroids were exclusively used in the IBD group. From IBD, 4 patients had the diagnosis of ulcerative colitis and 9 of Crohn’s disease with colonic involvement. Of these patients, 5 received IBD diagnosis after the acute episode of Aeromonas infection. Conclusions: Clinical presentation of Aeromonas infection differs between IBD and non-IBD patients. Non-IBD patients had milder severity of infection with less use of antibiotics. Aeromonas infection seems to greatly contribute to IBD manifestation.
format	article
author	Tiago Pereira Guedes Joana Alves Silva Sara Neves Daniela Falcão Paula Costa Paula Lago Isabel Pedroto Marta Salgado
author_facet	Tiago Pereira Guedes Joana Alves Silva Sara Neves Daniela Falcão Paula Costa Paula Lago Isabel Pedroto Marta Salgado
author_sort	Tiago Pereira Guedes
title	Positioning Aeromonas Infection in Inflammatory Bowel Disease: A Retrospective Analysis
title_short	Positioning Aeromonas Infection in Inflammatory Bowel Disease: A Retrospective Analysis
title_full	Positioning Aeromonas Infection in Inflammatory Bowel Disease: A Retrospective Analysis
title_fullStr	Positioning Aeromonas Infection in Inflammatory Bowel Disease: A Retrospective Analysis
title_full_unstemmed	Positioning Aeromonas Infection in Inflammatory Bowel Disease: A Retrospective Analysis
title_sort	positioning aeromonas infection in inflammatory bowel disease: a retrospective analysis
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/84bf928d3a8b4d2787ad7a4fa4c656ea
work_keys_str_mv	AT tiagopereiraguedes positioningaeromonasinfectionininflammatoryboweldiseasearetrospectiveanalysis AT joanaalvessilva positioningaeromonasinfectionininflammatoryboweldiseasearetrospectiveanalysis AT saraneves positioningaeromonasinfectionininflammatoryboweldiseasearetrospectiveanalysis AT danielafalcao positioningaeromonasinfectionininflammatoryboweldiseasearetrospectiveanalysis AT paulacosta positioningaeromonasinfectionininflammatoryboweldiseasearetrospectiveanalysis AT paulalago positioningaeromonasinfectionininflammatoryboweldiseasearetrospectiveanalysis AT isabelpedroto positioningaeromonasinfectionininflammatoryboweldiseasearetrospectiveanalysis AT martasalgado positioningaeromonasinfectionininflammatoryboweldiseasearetrospectiveanalysis
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Positioning Aeromonas Infection in Inflammatory Bowel Disease: A Retrospective Analysis

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