Kinesin-1 activity recorded in living cells with a precipitating dye

Monitoring the activity of the processive motor protein kinesin-1 in live cells is currently difficult. Here the authors report the fluorogenic small molecule QPD-OTf, a kinesin-1 substrate that causes activity-dependent dye precipitation.

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Autores principales:	Simona Angerani, Eric Lindberg, Nikolai Klena, Christopher K. E. Bleck, Charlotte Aumeier, Nicolas Winssinger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84c103ff473b4a30af353c47c941bdf3
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spelling	oai:doaj.org-article:84c103ff473b4a30af353c47c941bdf32021-12-02T15:52:50ZKinesin-1 activity recorded in living cells with a precipitating dye10.1038/s41467-021-21626-12041-1723https://doaj.org/article/84c103ff473b4a30af353c47c941bdf32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21626-1https://doaj.org/toc/2041-1723Monitoring the activity of the processive motor protein kinesin-1 in live cells is currently difficult. Here the authors report the fluorogenic small molecule QPD-OTf, a kinesin-1 substrate that causes activity-dependent dye precipitation.Simona AngeraniEric LindbergNikolai KlenaChristopher K. E. BleckCharlotte AumeierNicolas WinssingerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simona Angerani Eric Lindberg Nikolai Klena Christopher K. E. Bleck Charlotte Aumeier Nicolas Winssinger Kinesin-1 activity recorded in living cells with a precipitating dye
description	Monitoring the activity of the processive motor protein kinesin-1 in live cells is currently difficult. Here the authors report the fluorogenic small molecule QPD-OTf, a kinesin-1 substrate that causes activity-dependent dye precipitation.
format	article
author	Simona Angerani Eric Lindberg Nikolai Klena Christopher K. E. Bleck Charlotte Aumeier Nicolas Winssinger
author_facet	Simona Angerani Eric Lindberg Nikolai Klena Christopher K. E. Bleck Charlotte Aumeier Nicolas Winssinger
author_sort	Simona Angerani
title	Kinesin-1 activity recorded in living cells with a precipitating dye
title_short	Kinesin-1 activity recorded in living cells with a precipitating dye
title_full	Kinesin-1 activity recorded in living cells with a precipitating dye
title_fullStr	Kinesin-1 activity recorded in living cells with a precipitating dye
title_full_unstemmed	Kinesin-1 activity recorded in living cells with a precipitating dye
title_sort	kinesin-1 activity recorded in living cells with a precipitating dye
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/84c103ff473b4a30af353c47c941bdf3
work_keys_str_mv	AT simonaangerani kinesin1activityrecordedinlivingcellswithaprecipitatingdye AT ericlindberg kinesin1activityrecordedinlivingcellswithaprecipitatingdye AT nikolaiklena kinesin1activityrecordedinlivingcellswithaprecipitatingdye AT christopherkebleck kinesin1activityrecordedinlivingcellswithaprecipitatingdye AT charlotteaumeier kinesin1activityrecordedinlivingcellswithaprecipitatingdye AT nicolaswinssinger kinesin1activityrecordedinlivingcellswithaprecipitatingdye
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Kinesin-1 activity recorded in living cells with a precipitating dye

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