The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease
Rwei-Ling Yu,1 Chun-Hsiang Tan,2 Ruey-Meei Wu3 1Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Wolfson Centre for Age Related Diseases, King’s College London, London, UK; 3Department of Neurology, National Taiwan University Hospital...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2015
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/84c2d5fcfe224626a9299ad4f569b559 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:84c2d5fcfe224626a9299ad4f569b559 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:84c2d5fcfe224626a9299ad4f569b5592021-12-02T03:35:30ZThe impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease1178-2021https://doaj.org/article/84c2d5fcfe224626a9299ad4f569b5592015-08-01T00:00:00Zhttp://www.dovepress.com/the-impact-of-nocturnal-disturbances-on-daily-quality-of-life-in-patie-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Rwei-Ling Yu,1 Chun-Hsiang Tan,2 Ruey-Meei Wu3 1Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Wolfson Centre for Age Related Diseases, King’s College London, London, UK; 3Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Objectives: The aims of this study were to explore nocturnal disturbances in patients with Parkinson’s disease (PD) and to assess their impact on quality of life (QoL).Methods: A total of 211 patients with PD were recruited for this study, and each participant was evaluated using the mini-mental state examination, PD sleep scale – second version (PDSS-2), pittsburgh sleep quality index (PSQI), PD QoL questionnaire (PDQ), Epworth sleepiness scale, Hoehn and Yahr (H&Y) staging, and unified Parkinson’s disease rating scale (UPDRS). Multiple regression analyses were performed to determine the contribution of the predictive variables on QoL.Results: There were 56.4% males (mean age: 64.08 years; disease duration: 6.02 years; H&Y stage: 2.25; and UPDRS: 33.01) in this study. Our patients’ actual sleep time was 5.96±1.16 hours and the average sleep efficiency was 82.93%±12.79%. Up to 64.4% of patients were classified as “poor” sleepers and 23.8% suffered from daytime sleepiness. The final stepwise regression model revealed that UPDRS parts I and II, the sleep disturbance and daytime dysfunction components of the PSQI, the PD symptoms at night subscale of the PDSS-2, and the levodopa equivalent dose were significant predictors of the PDQ score (R2=53, F7,165=28.746; P<0.001).Conclusion: Most of the PD patients have sleep problems, and nearly one-quarter of them have abnormal daytime somnolence. The nocturnal disturbances were found to result in worse QoL in PD patients. Ethnicity-specific effects of susceptibility to sleep disturbances were discussed, and these results also highlighted the direction for further studies to explore when examining effective management programs toward these disturbances. Keywords: sleep, non-motor symptoms, Parkinson’s disease, quality of lifeYu RLTan CHWu RMDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2005-2012 (2015) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yu RL Tan CH Wu RM The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease |
| description |
Rwei-Ling Yu,1 Chun-Hsiang Tan,2 Ruey-Meei Wu3 1Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Wolfson Centre for Age Related Diseases, King’s College London, London, UK; 3Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Objectives: The aims of this study were to explore nocturnal disturbances in patients with Parkinson’s disease (PD) and to assess their impact on quality of life (QoL).Methods: A total of 211 patients with PD were recruited for this study, and each participant was evaluated using the mini-mental state examination, PD sleep scale – second version (PDSS-2), pittsburgh sleep quality index (PSQI), PD QoL questionnaire (PDQ), Epworth sleepiness scale, Hoehn and Yahr (H&Y) staging, and unified Parkinson’s disease rating scale (UPDRS). Multiple regression analyses were performed to determine the contribution of the predictive variables on QoL.Results: There were 56.4% males (mean age: 64.08 years; disease duration: 6.02 years; H&Y stage: 2.25; and UPDRS: 33.01) in this study. Our patients’ actual sleep time was 5.96±1.16 hours and the average sleep efficiency was 82.93%±12.79%. Up to 64.4% of patients were classified as “poor” sleepers and 23.8% suffered from daytime sleepiness. The final stepwise regression model revealed that UPDRS parts I and II, the sleep disturbance and daytime dysfunction components of the PSQI, the PD symptoms at night subscale of the PDSS-2, and the levodopa equivalent dose were significant predictors of the PDQ score (R2=53, F7,165=28.746; P<0.001).Conclusion: Most of the PD patients have sleep problems, and nearly one-quarter of them have abnormal daytime somnolence. The nocturnal disturbances were found to result in worse QoL in PD patients. Ethnicity-specific effects of susceptibility to sleep disturbances were discussed, and these results also highlighted the direction for further studies to explore when examining effective management programs toward these disturbances. Keywords: sleep, non-motor symptoms, Parkinson’s disease, quality of life |
| format |
article |
| author |
Yu RL Tan CH Wu RM |
| author_facet |
Yu RL Tan CH Wu RM |
| author_sort |
Yu RL |
| title |
The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease |
| title_short |
The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease |
| title_full |
The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease |
| title_fullStr |
The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease |
| title_full_unstemmed |
The impact of nocturnal disturbances on daily quality of life in patients with Parkinson’s disease |
| title_sort |
impact of nocturnal disturbances on daily quality of life in patients with parkinson’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/84c2d5fcfe224626a9299ad4f569b559 |
| work_keys_str_mv |
AT yurl theimpactofnocturnaldisturbancesondailyqualityoflifeinpatientswithparkinsonrsquosdisease AT tanch theimpactofnocturnaldisturbancesondailyqualityoflifeinpatientswithparkinsonrsquosdisease AT wurm theimpactofnocturnaldisturbancesondailyqualityoflifeinpatientswithparkinsonrsquosdisease AT yurl impactofnocturnaldisturbancesondailyqualityoflifeinpatientswithparkinsonrsquosdisease AT tanch impactofnocturnaldisturbancesondailyqualityoflifeinpatientswithparkinsonrsquosdisease AT wurm impactofnocturnaldisturbancesondailyqualityoflifeinpatientswithparkinsonrsquosdisease |
| _version_ |
1718401739377344512 |