Association between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5.

<h4>Background</h4>Several studies have revealed the relationship between serum magnesium levels and vascular calcification in chronic kidney disease patients. Despite excellent predictability of abdominal aorta calcification for cardiovascular disease events, the relationship between se...

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Autores principales: Mayumi Ito, Makoto Yamaguchi, Takayuki Katsuno, Hironobu Nobata, Shiho Iwagaitsu, Hirokazu Sugiyama, Hiroshi Kinashi, Shogo Banno, Masahiko Ando, Yoko Kubo, Takuji Ishimoto, Yasuhiko Ito
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Publicado: Public Library of Science (PLoS) 2021
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spelling oai:doaj.org-article:84c379b7e0654a20b5513e9d7e0998eb2021-12-02T20:10:20ZAssociation between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5.1932-620310.1371/journal.pone.0253592https://doaj.org/article/84c379b7e0654a20b5513e9d7e0998eb2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253592https://doaj.org/toc/1932-6203<h4>Background</h4>Several studies have revealed the relationship between serum magnesium levels and vascular calcification in chronic kidney disease patients. Despite excellent predictability of abdominal aorta calcification for cardiovascular disease events, the relationship between serum magnesium levels and abdominal aorta calcification, as evaluated by quantitative methods, in pre-dialysis patients remains unclear. This study aimed to determine the abdominal aorta calcification volume using computerized tomography and its association with serum magnesium levels in pre-dialysis chronic kidney disease stage 5 patients.<h4>Methods</h4>This single-center cross-sectional study included 100 consecutive patients with pre-dialysis chronic kidney disease stage 5 between January 2016 and May 2020 at Aichi Medical University Hospital, Japan. The relationships between serum magnesium levels and the abdominal aorta calcification volume were assessed using multiple linear regression models after adjusting for clinically relevant factors. We also assessed clinical factors that affect serum magnesium levels.<h4>Results</h4>The mean serum magnesium level was 2.0 mg/dL (interquartile range, 1.8 to 2.3). Multivariate analyses revealed that a higher serum magnesium level (stand. β = -0.245, p = 0.010) was significantly associated with a reduced abdominal aorta calcification volume, and that a history of cardiovascular disease (stand. β = 0.3792, p < 0.001) and older age (stand. β = 0.278, p = 0.007) were significantly associated with an increased abdominal aorta calcification volume. Moreover, multivariate analysis showed that the use of proton pump inhibitor or potassium-competitive acid blocker was significantly associated with lower serum magnesium levels (stand. β = -0.246, p = 0.019).<h4>Conclusions</h4>The present study revealed that the higher Mg level was significantly associated with lower volume of abdominal aorta calcification in pre-dialysis chronic kidney disease stage 5 patients. Further studies should be undertaken to determine the appropriate magnesium level to suppress vascular calcification.Mayumi ItoMakoto YamaguchiTakayuki KatsunoHironobu NobataShiho IwagaitsuHirokazu SugiyamaHiroshi KinashiShogo BannoMasahiko AndoYoko KuboTakuji IshimotoYasuhiko ItoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253592 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Mayumi Ito
Makoto Yamaguchi
Takayuki Katsuno
Hironobu Nobata
Shiho Iwagaitsu
Hirokazu Sugiyama
Hiroshi Kinashi
Shogo Banno
Masahiko Ando
Yoko Kubo
Takuji Ishimoto
Yasuhiko Ito
Association between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5.
description <h4>Background</h4>Several studies have revealed the relationship between serum magnesium levels and vascular calcification in chronic kidney disease patients. Despite excellent predictability of abdominal aorta calcification for cardiovascular disease events, the relationship between serum magnesium levels and abdominal aorta calcification, as evaluated by quantitative methods, in pre-dialysis patients remains unclear. This study aimed to determine the abdominal aorta calcification volume using computerized tomography and its association with serum magnesium levels in pre-dialysis chronic kidney disease stage 5 patients.<h4>Methods</h4>This single-center cross-sectional study included 100 consecutive patients with pre-dialysis chronic kidney disease stage 5 between January 2016 and May 2020 at Aichi Medical University Hospital, Japan. The relationships between serum magnesium levels and the abdominal aorta calcification volume were assessed using multiple linear regression models after adjusting for clinically relevant factors. We also assessed clinical factors that affect serum magnesium levels.<h4>Results</h4>The mean serum magnesium level was 2.0 mg/dL (interquartile range, 1.8 to 2.3). Multivariate analyses revealed that a higher serum magnesium level (stand. β = -0.245, p = 0.010) was significantly associated with a reduced abdominal aorta calcification volume, and that a history of cardiovascular disease (stand. β = 0.3792, p < 0.001) and older age (stand. β = 0.278, p = 0.007) were significantly associated with an increased abdominal aorta calcification volume. Moreover, multivariate analysis showed that the use of proton pump inhibitor or potassium-competitive acid blocker was significantly associated with lower serum magnesium levels (stand. β = -0.246, p = 0.019).<h4>Conclusions</h4>The present study revealed that the higher Mg level was significantly associated with lower volume of abdominal aorta calcification in pre-dialysis chronic kidney disease stage 5 patients. Further studies should be undertaken to determine the appropriate magnesium level to suppress vascular calcification.
format article
author Mayumi Ito
Makoto Yamaguchi
Takayuki Katsuno
Hironobu Nobata
Shiho Iwagaitsu
Hirokazu Sugiyama
Hiroshi Kinashi
Shogo Banno
Masahiko Ando
Yoko Kubo
Takuji Ishimoto
Yasuhiko Ito
author_facet Mayumi Ito
Makoto Yamaguchi
Takayuki Katsuno
Hironobu Nobata
Shiho Iwagaitsu
Hirokazu Sugiyama
Hiroshi Kinashi
Shogo Banno
Masahiko Ando
Yoko Kubo
Takuji Ishimoto
Yasuhiko Ito
author_sort Mayumi Ito
title Association between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5.
title_short Association between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5.
title_full Association between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5.
title_fullStr Association between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5.
title_full_unstemmed Association between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5.
title_sort association between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/84c379b7e0654a20b5513e9d7e0998eb
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