A network meta-analysis for neoadjuvant and adjuvant treatments for resectable squamous cell carcinoma of esophagus

Abstract The optimal treatment for resectable esophageal squamous cell carcinoma (ESCC) is still a debatable point; however, randomized trials for strategies including neoadjuvant or adjuvant chemotherapy (CT), radiotherapy, or chemoradiotherapy (CRT) are not always available. This network meta-anal...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yunpeng Zhao, Yongqiang Wang, Lei Shan, Chuanliang Peng, Wenhao Zhang, Xiaogang Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84c636098a304efe881a0c8968f6f874
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:84c636098a304efe881a0c8968f6f874
record_format	dspace
spelling	oai:doaj.org-article:84c636098a304efe881a0c8968f6f8742021-12-02T16:36:12ZA network meta-analysis for neoadjuvant and adjuvant treatments for resectable squamous cell carcinoma of esophagus10.1038/s41598-021-86102-82045-2322https://doaj.org/article/84c636098a304efe881a0c8968f6f8742021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86102-8https://doaj.org/toc/2045-2322Abstract The optimal treatment for resectable esophageal squamous cell carcinoma (ESCC) is still a debatable point; however, randomized trials for strategies including neoadjuvant or adjuvant chemotherapy (CT), radiotherapy, or chemoradiotherapy (CRT) are not always available. This network meta-analysis aimed to identify an effective approach through indirect comparisons. An extensive literature search comparing multimodality treatment and surgery was performed, and a network meta-analysis was conducted with the frequentist method. Twenty-three trials including a total of 3636 ESCC patients were included. Neoadjuvant CRT and neoadjuvant CT, which were recommended by most guidelines for esophageal cancer, were associated with an overall survival advantage compared with surgery alone (HR = 0.43, 95% CI 0.26–0.73; HR = 0.71, 95% CI 0.32–1.59). A statistically significant survival benefit from neoadjuvant CRT compared with neoadjuvant CT could not be demonstrated in our study (HR = 0.61, 95% CI 0.32–1.17, P = 0.08). Our network meta-analysis showed that both neoadjuvant CRT and neoadjuvant CT were effective in improving the survival of patients with ESCC. Individual clinical decisions need further study in the future.Yunpeng ZhaoYongqiang WangLei ShanChuanliang PengWenhao ZhangXiaogang ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yunpeng Zhao Yongqiang Wang Lei Shan Chuanliang Peng Wenhao Zhang Xiaogang Zhao A network meta-analysis for neoadjuvant and adjuvant treatments for resectable squamous cell carcinoma of esophagus
description	Abstract The optimal treatment for resectable esophageal squamous cell carcinoma (ESCC) is still a debatable point; however, randomized trials for strategies including neoadjuvant or adjuvant chemotherapy (CT), radiotherapy, or chemoradiotherapy (CRT) are not always available. This network meta-analysis aimed to identify an effective approach through indirect comparisons. An extensive literature search comparing multimodality treatment and surgery was performed, and a network meta-analysis was conducted with the frequentist method. Twenty-three trials including a total of 3636 ESCC patients were included. Neoadjuvant CRT and neoadjuvant CT, which were recommended by most guidelines for esophageal cancer, were associated with an overall survival advantage compared with surgery alone (HR = 0.43, 95% CI 0.26–0.73; HR = 0.71, 95% CI 0.32–1.59). A statistically significant survival benefit from neoadjuvant CRT compared with neoadjuvant CT could not be demonstrated in our study (HR = 0.61, 95% CI 0.32–1.17, P = 0.08). Our network meta-analysis showed that both neoadjuvant CRT and neoadjuvant CT were effective in improving the survival of patients with ESCC. Individual clinical decisions need further study in the future.
format	article
author	Yunpeng Zhao Yongqiang Wang Lei Shan Chuanliang Peng Wenhao Zhang Xiaogang Zhao
author_facet	Yunpeng Zhao Yongqiang Wang Lei Shan Chuanliang Peng Wenhao Zhang Xiaogang Zhao
author_sort	Yunpeng Zhao
title	A network meta-analysis for neoadjuvant and adjuvant treatments for resectable squamous cell carcinoma of esophagus
title_short	A network meta-analysis for neoadjuvant and adjuvant treatments for resectable squamous cell carcinoma of esophagus
title_full	A network meta-analysis for neoadjuvant and adjuvant treatments for resectable squamous cell carcinoma of esophagus
title_fullStr	A network meta-analysis for neoadjuvant and adjuvant treatments for resectable squamous cell carcinoma of esophagus
title_full_unstemmed	A network meta-analysis for neoadjuvant and adjuvant treatments for resectable squamous cell carcinoma of esophagus
title_sort	network meta-analysis for neoadjuvant and adjuvant treatments for resectable squamous cell carcinoma of esophagus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/84c636098a304efe881a0c8968f6f874
work_keys_str_mv	AT yunpengzhao anetworkmetaanalysisforneoadjuvantandadjuvanttreatmentsforresectablesquamouscellcarcinomaofesophagus AT yongqiangwang anetworkmetaanalysisforneoadjuvantandadjuvanttreatmentsforresectablesquamouscellcarcinomaofesophagus AT leishan anetworkmetaanalysisforneoadjuvantandadjuvanttreatmentsforresectablesquamouscellcarcinomaofesophagus AT chuanliangpeng anetworkmetaanalysisforneoadjuvantandadjuvanttreatmentsforresectablesquamouscellcarcinomaofesophagus AT wenhaozhang anetworkmetaanalysisforneoadjuvantandadjuvanttreatmentsforresectablesquamouscellcarcinomaofesophagus AT xiaogangzhao anetworkmetaanalysisforneoadjuvantandadjuvanttreatmentsforresectablesquamouscellcarcinomaofesophagus AT yunpengzhao networkmetaanalysisforneoadjuvantandadjuvanttreatmentsforresectablesquamouscellcarcinomaofesophagus AT yongqiangwang networkmetaanalysisforneoadjuvantandadjuvanttreatmentsforresectablesquamouscellcarcinomaofesophagus AT leishan networkmetaanalysisforneoadjuvantandadjuvanttreatmentsforresectablesquamouscellcarcinomaofesophagus AT chuanliangpeng networkmetaanalysisforneoadjuvantandadjuvanttreatmentsforresectablesquamouscellcarcinomaofesophagus AT wenhaozhang networkmetaanalysisforneoadjuvantandadjuvanttreatmentsforresectablesquamouscellcarcinomaofesophagus AT xiaogangzhao networkmetaanalysisforneoadjuvantandadjuvanttreatmentsforresectablesquamouscellcarcinomaofesophagus
_version_	1718383643048542208

A network meta-analysis for neoadjuvant and adjuvant treatments for resectable squamous cell carcinoma of esophagus

Ejemplares similares