Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/Superoxide dismutase/Catalase expressions, suppress lipid peroxidation and regulates histopathological changes

Streptozotocin (STZ) 60 mg/kg, i.p.-induced diabetes in rat’s results into hyperglycemia, impaired oxidative stress, lipid profile, insulin levels and changes in body weight. Treatment with antihyperglycemics and antioxidants are accounted to produce favorable effect in this paradigm. Fustin, a flav...

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Autores principales:	Sadaf Jamal Gilani, May Nasser Bin-Jumah, Fahad A. Al-Abbasi, Muhammad Shahid Nadeem, Muhammad Afzal, Nadeem Sayyed, Imran Kazmi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Blood glucose Body weight Diabetes Fustin Glyburide Lipid profile Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/84c949e613dd4f4fb92da3fed84cbc74
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spelling	oai:doaj.org-article:84c949e613dd4f4fb92da3fed84cbc742021-11-20T04:56:33ZFustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/Superoxide dismutase/Catalase expressions, suppress lipid peroxidation and regulates histopathological changes1319-562X10.1016/j.sjbs.2021.07.070https://doaj.org/article/84c949e613dd4f4fb92da3fed84cbc742021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21006537https://doaj.org/toc/1319-562XStreptozotocin (STZ) 60 mg/kg, i.p.-induced diabetes in rat’s results into hyperglycemia, impaired oxidative stress, lipid profile, insulin levels and changes in body weight. Treatment with antihyperglycemics and antioxidants are accounted to produce favorable effect in this paradigm. Fustin, a flavonoid derived from Rhus verniciflua, extract of Rhus verniciflua reported to exhibit anti-hyperglycemic, antioxidant, anti-microbial, anti-arthritic effects, anti-obesity effects, antiplatelet effects and anti-cancer effects. However, no evidence is existing on effect of fustin on STZ-induction diabetes. Thus, we evaluated its effects against diabetes in STZ-induced rodents. Blood glucose, Insulin, lipid peroxidation (MDA), superoxide dismutase (SOD), catalase activity (CAT), glutathione (GSH) and lipid profile levels was assessed. After 30 days diabetes induction rodents showed a severe increased blood sugar level, MDA, high density lipid and decreased cholestrol, triglyceride, GSH, SOD, CAT, respectively.Oppositely, treatment with fustin (50–100 mg/kg/p.o., two times daily, 30 days) enhanced blood glucose, lipid profile levels Insulin. Meanwhile, reduced MDA and enhanced GSH, SOD, and CAT in diabetic rats. Glibenclamide 5 mg/kg/p.o. also enhanced diabetes-induced complications and decreased oxidative stress. Further histopathology of pancreas confirms the protective effect fustin in STZ-induction diabetes in animals. In conclusion, the study revealed treatments with fustin avoid the changes in body weight, blood glucose, lipid profile and oxidative stress. As a results of these finding may lead to the growth of a choice of medicine for hyperglycemic in the future.Sadaf Jamal GilaniMay Nasser Bin-JumahFahad A. Al-AbbasiMuhammad Shahid NadeemMuhammad AfzalNadeem SayyedImran KazmiElsevierarticleBlood glucoseBody weightDiabetesFustinGlyburideLipid profileBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 6963-6971 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Blood glucose Body weight Diabetes Fustin Glyburide Lipid profile Biology (General) QH301-705.5
spellingShingle	Blood glucose Body weight Diabetes Fustin Glyburide Lipid profile Biology (General) QH301-705.5 Sadaf Jamal Gilani May Nasser Bin-Jumah Fahad A. Al-Abbasi Muhammad Shahid Nadeem Muhammad Afzal Nadeem Sayyed Imran Kazmi Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/Superoxide dismutase/Catalase expressions, suppress lipid peroxidation and regulates histopathological changes
description	Streptozotocin (STZ) 60 mg/kg, i.p.-induced diabetes in rat’s results into hyperglycemia, impaired oxidative stress, lipid profile, insulin levels and changes in body weight. Treatment with antihyperglycemics and antioxidants are accounted to produce favorable effect in this paradigm. Fustin, a flavonoid derived from Rhus verniciflua, extract of Rhus verniciflua reported to exhibit anti-hyperglycemic, antioxidant, anti-microbial, anti-arthritic effects, anti-obesity effects, antiplatelet effects and anti-cancer effects. However, no evidence is existing on effect of fustin on STZ-induction diabetes. Thus, we evaluated its effects against diabetes in STZ-induced rodents. Blood glucose, Insulin, lipid peroxidation (MDA), superoxide dismutase (SOD), catalase activity (CAT), glutathione (GSH) and lipid profile levels was assessed. After 30 days diabetes induction rodents showed a severe increased blood sugar level, MDA, high density lipid and decreased cholestrol, triglyceride, GSH, SOD, CAT, respectively.Oppositely, treatment with fustin (50–100 mg/kg/p.o., two times daily, 30 days) enhanced blood glucose, lipid profile levels Insulin. Meanwhile, reduced MDA and enhanced GSH, SOD, and CAT in diabetic rats. Glibenclamide 5 mg/kg/p.o. also enhanced diabetes-induced complications and decreased oxidative stress. Further histopathology of pancreas confirms the protective effect fustin in STZ-induction diabetes in animals. In conclusion, the study revealed treatments with fustin avoid the changes in body weight, blood glucose, lipid profile and oxidative stress. As a results of these finding may lead to the growth of a choice of medicine for hyperglycemic in the future.
format	article
author	Sadaf Jamal Gilani May Nasser Bin-Jumah Fahad A. Al-Abbasi Muhammad Shahid Nadeem Muhammad Afzal Nadeem Sayyed Imran Kazmi
author_facet	Sadaf Jamal Gilani May Nasser Bin-Jumah Fahad A. Al-Abbasi Muhammad Shahid Nadeem Muhammad Afzal Nadeem Sayyed Imran Kazmi
author_sort	Sadaf Jamal Gilani
title	Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/Superoxide dismutase/Catalase expressions, suppress lipid peroxidation and regulates histopathological changes
title_short	Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/Superoxide dismutase/Catalase expressions, suppress lipid peroxidation and regulates histopathological changes
title_full	Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/Superoxide dismutase/Catalase expressions, suppress lipid peroxidation and regulates histopathological changes
title_fullStr	Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/Superoxide dismutase/Catalase expressions, suppress lipid peroxidation and regulates histopathological changes
title_full_unstemmed	Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/Superoxide dismutase/Catalase expressions, suppress lipid peroxidation and regulates histopathological changes
title_sort	fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/superoxide dismutase/catalase expressions, suppress lipid peroxidation and regulates histopathological changes
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/84c949e613dd4f4fb92da3fed84cbc74
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Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/Superoxide dismutase/Catalase expressions, suppress lipid peroxidation and regulates histopathological changes

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