Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

Macrophages play an important role in wound healing but the guidance cues driving macrophages to sites of repair are still not clear. Here the authors discover that macrophages are attracted to contracting fibroblasts by responding to locally sensed displacements of collagen fibres.

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Detalles Bibliográficos
Autores principales: Pardis Pakshir, Moien Alizadehgiashi, Boaz Wong, Nuno Miranda Coelho, Xingyu Chen, Ze Gong, Vivek B. Shenoy, Christopher A. McCulloch, Boris Hinz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/84d14772127947a79875197d524838dc
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Sumario:Macrophages play an important role in wound healing but the guidance cues driving macrophages to sites of repair are still not clear. Here the authors discover that macrophages are attracted to contracting fibroblasts by responding to locally sensed displacements of collagen fibres.