Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

Macrophages play an important role in wound healing but the guidance cues driving macrophages to sites of repair are still not clear. Here the authors discover that macrophages are attracted to contracting fibroblasts by responding to locally sensed displacements of collagen fibres.

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Autores principales:	Pardis Pakshir, Moien Alizadehgiashi, Boaz Wong, Nuno Miranda Coelho, Xingyu Chen, Ze Gong, Vivek B. Shenoy, Christopher A. McCulloch, Boris Hinz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84d14772127947a79875197d524838dc
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spelling	oai:doaj.org-article:84d14772127947a79875197d524838dc2021-12-02T17:01:58ZDynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix10.1038/s41467-019-09709-62041-1723https://doaj.org/article/84d14772127947a79875197d524838dc2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09709-6https://doaj.org/toc/2041-1723Macrophages play an important role in wound healing but the guidance cues driving macrophages to sites of repair are still not clear. Here the authors discover that macrophages are attracted to contracting fibroblasts by responding to locally sensed displacements of collagen fibres.Pardis PakshirMoien AlizadehgiashiBoaz WongNuno Miranda CoelhoXingyu ChenZe GongVivek B. ShenoyChristopher A. McCullochBoris HinzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pardis Pakshir Moien Alizadehgiashi Boaz Wong Nuno Miranda Coelho Xingyu Chen Ze Gong Vivek B. Shenoy Christopher A. McCulloch Boris Hinz Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix
description	Macrophages play an important role in wound healing but the guidance cues driving macrophages to sites of repair are still not clear. Here the authors discover that macrophages are attracted to contracting fibroblasts by responding to locally sensed displacements of collagen fibres.
format	article
author	Pardis Pakshir Moien Alizadehgiashi Boaz Wong Nuno Miranda Coelho Xingyu Chen Ze Gong Vivek B. Shenoy Christopher A. McCulloch Boris Hinz
author_facet	Pardis Pakshir Moien Alizadehgiashi Boaz Wong Nuno Miranda Coelho Xingyu Chen Ze Gong Vivek B. Shenoy Christopher A. McCulloch Boris Hinz
author_sort	Pardis Pakshir
title	Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix
title_short	Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix
title_full	Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix
title_fullStr	Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix
title_full_unstemmed	Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix
title_sort	dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/84d14772127947a79875197d524838dc
work_keys_str_mv	AT pardispakshir dynamicfibroblastcontractionsattractremotemacrophagesinfibrillarcollagenmatrix AT moienalizadehgiashi dynamicfibroblastcontractionsattractremotemacrophagesinfibrillarcollagenmatrix AT boazwong dynamicfibroblastcontractionsattractremotemacrophagesinfibrillarcollagenmatrix AT nunomirandacoelho dynamicfibroblastcontractionsattractremotemacrophagesinfibrillarcollagenmatrix AT xingyuchen dynamicfibroblastcontractionsattractremotemacrophagesinfibrillarcollagenmatrix AT zegong dynamicfibroblastcontractionsattractremotemacrophagesinfibrillarcollagenmatrix AT vivekbshenoy dynamicfibroblastcontractionsattractremotemacrophagesinfibrillarcollagenmatrix AT christopheramcculloch dynamicfibroblastcontractionsattractremotemacrophagesinfibrillarcollagenmatrix AT borishinz dynamicfibroblastcontractionsattractremotemacrophagesinfibrillarcollagenmatrix
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Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

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