Ikk2 regulates cytokinesis during vertebrate development

Abstract NFκB signaling has a pivotal role in regulation of development, innate immunity, and inflammation. Ikk2 is one of the two critical kinases that regulate the NFκB signaling pathway. While the role of Ikk2 in immunity, inflammation and oncogenesis has received attention, an understanding of t...

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Autores principales:	Hongyuan Shen, Eun Myoung Shin, Serene Lee, Sinnakaruppan Mathavan, Hiromi Koh, Motomi Osato, Hyungwon Choi, Vinay Tergaonkar, Vladimir Korzh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84d378fde22c4460a6c133a1234478c2
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spelling	oai:doaj.org-article:84d378fde22c4460a6c133a1234478c22021-12-02T12:32:16ZIkk2 regulates cytokinesis during vertebrate development10.1038/s41598-017-06904-72045-2322https://doaj.org/article/84d378fde22c4460a6c133a1234478c22017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06904-7https://doaj.org/toc/2045-2322Abstract NFκB signaling has a pivotal role in regulation of development, innate immunity, and inflammation. Ikk2 is one of the two critical kinases that regulate the NFκB signaling pathway. While the role of Ikk2 in immunity, inflammation and oncogenesis has received attention, an understanding of the role of Ikk2 in vertebrate development has been compounded by the embryonic lethality seen in mice lacking Ikk2. We find that despite abnormal angiogenesis in IKK2 zygotic mutants of zebrafish, the maternal activity of Ikk2 supports embryogenesis and maturation of fertile animals and allows to study the role of IKK2 in development. Maternal-zygotic ikk2 mutants represent the first vertebrates globally devoid of maternal and zygotic Ikk2 activity. They are defective in cell proliferation as evidenced by abnormal cytokinesis, nuclear enlargement and syncytialisation of a significant portion of blastoderm. We further document that reduced phosphorylation of Aurora A by Ikk2 could underlie the basis of these defects in cell division.Hongyuan ShenEun Myoung ShinSerene LeeSinnakaruppan MathavanHiromi KohMotomi OsatoHyungwon ChoiVinay TergaonkarVladimir KorzhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hongyuan Shen Eun Myoung Shin Serene Lee Sinnakaruppan Mathavan Hiromi Koh Motomi Osato Hyungwon Choi Vinay Tergaonkar Vladimir Korzh Ikk2 regulates cytokinesis during vertebrate development
description	Abstract NFκB signaling has a pivotal role in regulation of development, innate immunity, and inflammation. Ikk2 is one of the two critical kinases that regulate the NFκB signaling pathway. While the role of Ikk2 in immunity, inflammation and oncogenesis has received attention, an understanding of the role of Ikk2 in vertebrate development has been compounded by the embryonic lethality seen in mice lacking Ikk2. We find that despite abnormal angiogenesis in IKK2 zygotic mutants of zebrafish, the maternal activity of Ikk2 supports embryogenesis and maturation of fertile animals and allows to study the role of IKK2 in development. Maternal-zygotic ikk2 mutants represent the first vertebrates globally devoid of maternal and zygotic Ikk2 activity. They are defective in cell proliferation as evidenced by abnormal cytokinesis, nuclear enlargement and syncytialisation of a significant portion of blastoderm. We further document that reduced phosphorylation of Aurora A by Ikk2 could underlie the basis of these defects in cell division.
format	article
author	Hongyuan Shen Eun Myoung Shin Serene Lee Sinnakaruppan Mathavan Hiromi Koh Motomi Osato Hyungwon Choi Vinay Tergaonkar Vladimir Korzh
author_facet	Hongyuan Shen Eun Myoung Shin Serene Lee Sinnakaruppan Mathavan Hiromi Koh Motomi Osato Hyungwon Choi Vinay Tergaonkar Vladimir Korzh
author_sort	Hongyuan Shen
title	Ikk2 regulates cytokinesis during vertebrate development
title_short	Ikk2 regulates cytokinesis during vertebrate development
title_full	Ikk2 regulates cytokinesis during vertebrate development
title_fullStr	Ikk2 regulates cytokinesis during vertebrate development
title_full_unstemmed	Ikk2 regulates cytokinesis during vertebrate development
title_sort	ikk2 regulates cytokinesis during vertebrate development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/84d378fde22c4460a6c133a1234478c2
work_keys_str_mv	AT hongyuanshen ikk2regulatescytokinesisduringvertebratedevelopment AT eunmyoungshin ikk2regulatescytokinesisduringvertebratedevelopment AT serenelee ikk2regulatescytokinesisduringvertebratedevelopment AT sinnakaruppanmathavan ikk2regulatescytokinesisduringvertebratedevelopment AT hiromikoh ikk2regulatescytokinesisduringvertebratedevelopment AT motomiosato ikk2regulatescytokinesisduringvertebratedevelopment AT hyungwonchoi ikk2regulatescytokinesisduringvertebratedevelopment AT vinaytergaonkar ikk2regulatescytokinesisduringvertebratedevelopment AT vladimirkorzh ikk2regulatescytokinesisduringvertebratedevelopment
_version_	1718394104592728064

Ikk2 regulates cytokinesis during vertebrate development

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