Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone

Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone

Lei Wang, Kai Zhang, Yongqiang Hao, Ming Liu, Wen WuDepartment of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, People’s Republic of ChinaAbstract: The porous surf...

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Autores principales: Wang L, Zhang K, Hao Y, Liu M, Wu W
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
polyetheretherketone
nanoporous lithium doped magnesium silicate
porously bioactive surface
cells responses
osteogenesis
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/84d390f291fd4d2c87a7e62df0a01cb8
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spelling oai:doaj.org-article:84d390f291fd4d2c87a7e62df0a01cb82021-12-02T06:23:56ZOsteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone1178-2013https://doaj.org/article/84d390f291fd4d2c87a7e62df0a01cb82019-07-01T00:00:00Zhttps://www.dovepress.com/osteoblastbone-tissue-responses-to-porous-surface-of-polyetheretherket-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Lei Wang, Kai Zhang, Yongqiang Hao, Ming Liu, Wen WuDepartment of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, People’s Republic of ChinaAbstract: The porous surface of a polyetheretherketone (PK)–nanoporous lithium-doped magnesium silicate (NLS) blend (PKNLS) was fabricated on a PK surface by layer-by-layer pressuring, sintering, and salt-leaching. As controls, porous surfaces of a PK/lithium-doped magnesium silicate blend (PKLS) and PK were fabricated using the same method. The results revealed that porosity, water absorption, and protein absorption of the porous surface of PKNLS containing macropores and nanopores were obviously enhanced compared to PKLS and PK containing macropores without nanopores. In addition, PKNLS, with both macroporostiy and nanoporosity, displayed the highest ability of apatite mineralization in simulated body liquid, indicating excellent bioactivity. In vitro responses (including adhesion, proliferation, and differentiation) of MC3T3E1 cells to PKNLS were significantly enhanced compared to PKLS and PK. In vivo implantation results showed that new bone grew into the macroporous surface of PKNLS, and the amount of new bone for PKNLS was the highest. In short, PKNLS integration with PK significantly promoted cells/bone-tissue responses and exhibited excellent osteogenesis in vivo, which might have great potential for bone repair.Keywords: polyetheretherketone, nanoporous lithium doped magnesium silicate, porously bioactive surface, cells responses, osteogenesisWang LZhang KHao YLiu MWu WDove Medical Pressarticlepolyetheretherketonenanoporous lithium doped magnesium silicateporously bioactive surfacecells responsesosteogenesisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4975-4989 (2019)
institution DOAJ
collection DOAJ
language EN
topic polyetheretherketone
nanoporous lithium doped magnesium silicate
porously bioactive surface
cells responses
osteogenesis
Medicine (General)
R5-920
spellingShingle polyetheretherketone
nanoporous lithium doped magnesium silicate
porously bioactive surface
cells responses
osteogenesis
Medicine (General)
R5-920
Wang L
Zhang K
Hao Y
Liu M
Wu W
Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone
description Lei Wang, Kai Zhang, Yongqiang Hao, Ming Liu, Wen WuDepartment of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, People’s Republic of ChinaAbstract: The porous surface of a polyetheretherketone (PK)–nanoporous lithium-doped magnesium silicate (NLS) blend (PKNLS) was fabricated on a PK surface by layer-by-layer pressuring, sintering, and salt-leaching. As controls, porous surfaces of a PK/lithium-doped magnesium silicate blend (PKLS) and PK were fabricated using the same method. The results revealed that porosity, water absorption, and protein absorption of the porous surface of PKNLS containing macropores and nanopores were obviously enhanced compared to PKLS and PK containing macropores without nanopores. In addition, PKNLS, with both macroporostiy and nanoporosity, displayed the highest ability of apatite mineralization in simulated body liquid, indicating excellent bioactivity. In vitro responses (including adhesion, proliferation, and differentiation) of MC3T3E1 cells to PKNLS were significantly enhanced compared to PKLS and PK. In vivo implantation results showed that new bone grew into the macroporous surface of PKNLS, and the amount of new bone for PKNLS was the highest. In short, PKNLS integration with PK significantly promoted cells/bone-tissue responses and exhibited excellent osteogenesis in vivo, which might have great potential for bone repair.Keywords: polyetheretherketone, nanoporous lithium doped magnesium silicate, porously bioactive surface, cells responses, osteogenesis
format article
author Wang L
Zhang K
Hao Y
Liu M
Wu W
author_facet Wang L
Zhang K
Hao Y
Liu M
Wu W
author_sort Wang L
title Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone
title_short Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone
title_full Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone
title_fullStr Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone
title_full_unstemmed Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone
title_sort osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/84d390f291fd4d2c87a7e62df0a01cb8
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AT haoy osteoblastbonetissueresponsestoporoussurfaceofpolyetheretherketonendashnanoporouslithiumdopedmagnesiumsilicateblendsrsquointegrationwithpolyetheretherketone
AT lium osteoblastbonetissueresponsestoporoussurfaceofpolyetheretherketonendashnanoporouslithiumdopedmagnesiumsilicateblendsrsquointegrationwithpolyetheretherketone
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