Assessment of a Non-Invasive Brain Oximeter in a Sheep Model of Acute Brain Injury

Barry Dixon,1 Renee Turner,2 Chris Christou3 1Cyban Pty Ltd, Melbourne, VIC, Australia; 2Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia; 3Preclinical Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Adelaide, SA, AustraliaCorrespond...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dixon B, Turner R, Christou C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	oximetry traumatic brain injury brain sheep. Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/84d4cb5cc573446f8a5e17da7f3ff529
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:84d4cb5cc573446f8a5e17da7f3ff529
record_format	dspace
spelling	oai:doaj.org-article:84d4cb5cc573446f8a5e17da7f3ff5292021-12-02T07:57:27ZAssessment of a Non-Invasive Brain Oximeter in a Sheep Model of Acute Brain Injury1179-1470https://doaj.org/article/84d4cb5cc573446f8a5e17da7f3ff5292019-12-01T00:00:00Zhttps://www.dovepress.com/assessment-of-a-non-invasive-brain-oximeter-in-a-sheep-model-of-acute--peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470Barry Dixon,1 Renee Turner,2 Chris Christou3 1Cyban Pty Ltd, Melbourne, VIC, Australia; 2Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia; 3Preclinical Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Adelaide, SA, AustraliaCorrespondence: Barry DixonCyban Pty Ltd, Melbourne, VIC, AustraliaTel +61 439618815Email bazalgette.dixon@gmail.comIntroduction: Evidence suggests treatments guided by brain oxygen levels improve patient outcomes following severe traumatic brain injury; however, brain oxygen levels are not routinely monitored as an effective non-invasive method has not been established. We undertook a study, in a sheep model of acute brain injury, to assess a new non-invasive brain oximeter. The monitor uses the principles of pulse oximetry to record a pulse and oxygen levels.Methods: We studied 8 sheep. An acute increase in intracranial pressure was induced with an injection of blood into the cranial vault. The temporal changes in the brain oximeter, intracranial pressure and cerebral perfusion pressure were recorded. Simultaneous conventional skin pulse oximetry was also recorded to assess the possible influence of skin blood flow on the brain oximeter signal.Results: At baseline, a pulsatile waveform consistent with the brain circulation was obtained in 7 animals. The baseline brain pulse was quite distinct from the simultaneous conventional skin pulse and similar in shape to a central venous pressure waveform. Injection of blood into the cranial vault triggered an immediate increase in intracranial pressure and fall in cerebral perfusion pressure, by 60-s cerebral perfusion pressure recovered. The brain oximeter oxygen levels demonstrated similar changes with an immediate fall and recovery by 60 s. Periods of high intracranial pressure were also associated with high-frequency oscillations in the brain pulse waveform; there was, however, no change in the conventional skin pulse oximeter pulse waveform.Conclusion: The brain oximeter detected acute changes in both oxygen levels and the brain pulse waveform following an increase in intracranial pressure levels. The brain oximeter could assist clinicians in the management of acute brain injury.Keywords: oximetry, traumatic brain injury, brain, sheepDixon BTurner RChristou CDove Medical Pressarticleoximetrytraumatic brain injurybrainsheep.Medical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol Volume 12, Pp 479-487 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	oximetry traumatic brain injury brain sheep. Medical technology R855-855.5
spellingShingle	oximetry traumatic brain injury brain sheep. Medical technology R855-855.5 Dixon B Turner R Christou C Assessment of a Non-Invasive Brain Oximeter in a Sheep Model of Acute Brain Injury
description	Barry Dixon,1 Renee Turner,2 Chris Christou3 1Cyban Pty Ltd, Melbourne, VIC, Australia; 2Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia; 3Preclinical Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Adelaide, SA, AustraliaCorrespondence: Barry DixonCyban Pty Ltd, Melbourne, VIC, AustraliaTel +61 439618815Email bazalgette.dixon@gmail.comIntroduction: Evidence suggests treatments guided by brain oxygen levels improve patient outcomes following severe traumatic brain injury; however, brain oxygen levels are not routinely monitored as an effective non-invasive method has not been established. We undertook a study, in a sheep model of acute brain injury, to assess a new non-invasive brain oximeter. The monitor uses the principles of pulse oximetry to record a pulse and oxygen levels.Methods: We studied 8 sheep. An acute increase in intracranial pressure was induced with an injection of blood into the cranial vault. The temporal changes in the brain oximeter, intracranial pressure and cerebral perfusion pressure were recorded. Simultaneous conventional skin pulse oximetry was also recorded to assess the possible influence of skin blood flow on the brain oximeter signal.Results: At baseline, a pulsatile waveform consistent with the brain circulation was obtained in 7 animals. The baseline brain pulse was quite distinct from the simultaneous conventional skin pulse and similar in shape to a central venous pressure waveform. Injection of blood into the cranial vault triggered an immediate increase in intracranial pressure and fall in cerebral perfusion pressure, by 60-s cerebral perfusion pressure recovered. The brain oximeter oxygen levels demonstrated similar changes with an immediate fall and recovery by 60 s. Periods of high intracranial pressure were also associated with high-frequency oscillations in the brain pulse waveform; there was, however, no change in the conventional skin pulse oximeter pulse waveform.Conclusion: The brain oximeter detected acute changes in both oxygen levels and the brain pulse waveform following an increase in intracranial pressure levels. The brain oximeter could assist clinicians in the management of acute brain injury.Keywords: oximetry, traumatic brain injury, brain, sheep
format	article
author	Dixon B Turner R Christou C
author_facet	Dixon B Turner R Christou C
author_sort	Dixon B
title	Assessment of a Non-Invasive Brain Oximeter in a Sheep Model of Acute Brain Injury
title_short	Assessment of a Non-Invasive Brain Oximeter in a Sheep Model of Acute Brain Injury
title_full	Assessment of a Non-Invasive Brain Oximeter in a Sheep Model of Acute Brain Injury
title_fullStr	Assessment of a Non-Invasive Brain Oximeter in a Sheep Model of Acute Brain Injury
title_full_unstemmed	Assessment of a Non-Invasive Brain Oximeter in a Sheep Model of Acute Brain Injury
title_sort	assessment of a non-invasive brain oximeter in a sheep model of acute brain injury
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/84d4cb5cc573446f8a5e17da7f3ff529
work_keys_str_mv	AT dixonb assessmentofanoninvasivebrainoximeterinasheepmodelofacutebraininjury AT turnerr assessmentofanoninvasivebrainoximeterinasheepmodelofacutebraininjury AT christouc assessmentofanoninvasivebrainoximeterinasheepmodelofacutebraininjury
_version_	1718399051372691456

Assessment of a Non-Invasive Brain Oximeter in a Sheep Model of Acute Brain Injury

Ejemplares similares