Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2

Proteinuria promotes chronic kidney disease progression. Karoui et al. show that proteinuria stimulates overexpression of iron transporting protein lipocalin-2 via Ca2+release-induced ER stress, which leads to tubular apoptosis, and that inhibition of this pathway by PBA delays renal deterioration i...

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Autores principales:	Khalil El Karoui, Amandine Viau, Olivier Dellis, Alessia Bagattin, Clément Nguyen, William Baron, Martine Burtin, Mélanie Broueilh, Laurence Heidet, Géraldine Mollet, Anne Druilhe, Corinne Antignac, Bertrand Knebelmann, Gérard Friedlander, Frank Bienaimé, Morgan Gallazzini, Fabiola Terzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84d6beb4c2bc4aa9bafacf3ebe31468b
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spelling	oai:doaj.org-article:84d6beb4c2bc4aa9bafacf3ebe31468b2021-12-02T15:35:41ZEndoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 210.1038/ncomms103302041-1723https://doaj.org/article/84d6beb4c2bc4aa9bafacf3ebe31468b2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10330https://doaj.org/toc/2041-1723Proteinuria promotes chronic kidney disease progression. Karoui et al. show that proteinuria stimulates overexpression of iron transporting protein lipocalin-2 via Ca2+release-induced ER stress, which leads to tubular apoptosis, and that inhibition of this pathway by PBA delays renal deterioration in proteinuric mice.Khalil El KarouiAmandine ViauOlivier DellisAlessia BagattinClément NguyenWilliam BaronMartine BurtinMélanie BroueilhLaurence HeidetGéraldine MolletAnne DruilheCorinne AntignacBertrand KnebelmannGérard FriedlanderFrank BienaiméMorgan GallazziniFabiola TerziNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Khalil El Karoui Amandine Viau Olivier Dellis Alessia Bagattin Clément Nguyen William Baron Martine Burtin Mélanie Broueilh Laurence Heidet Géraldine Mollet Anne Druilhe Corinne Antignac Bertrand Knebelmann Gérard Friedlander Frank Bienaimé Morgan Gallazzini Fabiola Terzi Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2
description	Proteinuria promotes chronic kidney disease progression. Karoui et al. show that proteinuria stimulates overexpression of iron transporting protein lipocalin-2 via Ca2+release-induced ER stress, which leads to tubular apoptosis, and that inhibition of this pathway by PBA delays renal deterioration in proteinuric mice.
format	article
author	Khalil El Karoui Amandine Viau Olivier Dellis Alessia Bagattin Clément Nguyen William Baron Martine Burtin Mélanie Broueilh Laurence Heidet Géraldine Mollet Anne Druilhe Corinne Antignac Bertrand Knebelmann Gérard Friedlander Frank Bienaimé Morgan Gallazzini Fabiola Terzi
author_facet	Khalil El Karoui Amandine Viau Olivier Dellis Alessia Bagattin Clément Nguyen William Baron Martine Burtin Mélanie Broueilh Laurence Heidet Géraldine Mollet Anne Druilhe Corinne Antignac Bertrand Knebelmann Gérard Friedlander Frank Bienaimé Morgan Gallazzini Fabiola Terzi
author_sort	Khalil El Karoui
title	Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2
title_short	Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2
title_full	Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2
title_fullStr	Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2
title_full_unstemmed	Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2
title_sort	endoplasmic reticulum stress drives proteinuria-induced kidney lesions via lipocalin 2
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/84d6beb4c2bc4aa9bafacf3ebe31468b
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Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2

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