Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche

Mice lacking telomerase provide a model to study pathogenesis caused by critical telomere shortening. Here, the authors provide evidence that telomere shortening causes downregulation of Wnt signalling in intestinal crypts and that defects can be partially rescued by treatment with Wnt agonists.

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Bibliographic Details
Main Authors:	Ting-Lin B. Yang, Qijun Chen, Jennifer T. Deng, Geetha Jagannathan, John W. Tobias, David C. Schultz, Shan Wang, Christopher J. Lengner, Anil K. Rustgi, John P. Lynch, F. Brad Johnson
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/84db73bd9d44488982b5724af9d64be0
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spelling	oai:doaj.org-article:84db73bd9d44488982b5724af9d64be02021-12-02T14:42:07ZMutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche10.1038/ncomms147662041-1723https://doaj.org/article/84db73bd9d44488982b5724af9d64be02017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14766https://doaj.org/toc/2041-1723Mice lacking telomerase provide a model to study pathogenesis caused by critical telomere shortening. Here, the authors provide evidence that telomere shortening causes downregulation of Wnt signalling in intestinal crypts and that defects can be partially rescued by treatment with Wnt agonists.Ting-Lin B. YangQijun ChenJennifer T. DengGeetha JagannathanJohn W. TobiasDavid C. SchultzShan WangChristopher J. LengnerAnil K. RustgiJohn P. LynchF. Brad JohnsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ting-Lin B. Yang Qijun Chen Jennifer T. Deng Geetha Jagannathan John W. Tobias David C. Schultz Shan Wang Christopher J. Lengner Anil K. Rustgi John P. Lynch F. Brad Johnson Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche
description	Mice lacking telomerase provide a model to study pathogenesis caused by critical telomere shortening. Here, the authors provide evidence that telomere shortening causes downregulation of Wnt signalling in intestinal crypts and that defects can be partially rescued by treatment with Wnt agonists.
format	article
author	Ting-Lin B. Yang Qijun Chen Jennifer T. Deng Geetha Jagannathan John W. Tobias David C. Schultz Shan Wang Christopher J. Lengner Anil K. Rustgi John P. Lynch F. Brad Johnson
author_facet	Ting-Lin B. Yang Qijun Chen Jennifer T. Deng Geetha Jagannathan John W. Tobias David C. Schultz Shan Wang Christopher J. Lengner Anil K. Rustgi John P. Lynch F. Brad Johnson
author_sort	Ting-Lin B. Yang
title	Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche
title_short	Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche
title_full	Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche
title_fullStr	Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche
title_full_unstemmed	Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche
title_sort	mutual reinforcement between telomere capping and canonical wnt signalling in the intestinal stem cell niche
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/84db73bd9d44488982b5724af9d64be0
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Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche

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