SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis

Upstream pathways regulating Brg1 stability and their role in carcinogenesis are unknown. Here they show Brg1 to be phosphorylated by CK1δ to promote its ubiquitination by SCFFBW7 (FBW7), Brg1 stabilization to promote gastric cancer metastasis, and suggest targeting Brg1 in FBW7 compromised gastric...

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Autores principales:	Li-Yu Huang, Junjie Zhao, Hao Chen, Lixin Wan, Hiroyuki Inuzuka, Jianping Guo, Xuhong Fu, Yangyang Zhai, Zhaoning Lu, Xuefei Wang, Ze-Guang Han, Yihong Sun, Wenyi Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84dbbd4c59c645519a4588dd6fbb6578
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spelling	oai:doaj.org-article:84dbbd4c59c645519a4588dd6fbb65782021-12-02T17:32:16ZSCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis10.1038/s41467-018-06038-y2041-1723https://doaj.org/article/84dbbd4c59c645519a4588dd6fbb65782018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06038-yhttps://doaj.org/toc/2041-1723Upstream pathways regulating Brg1 stability and their role in carcinogenesis are unknown. Here they show Brg1 to be phosphorylated by CK1δ to promote its ubiquitination by SCFFBW7 (FBW7), Brg1 stabilization to promote gastric cancer metastasis, and suggest targeting Brg1 in FBW7 compromised gastric cancer.Li-Yu HuangJunjie ZhaoHao ChenLixin WanHiroyuki InuzukaJianping GuoXuhong FuYangyang ZhaiZhaoning LuXuefei WangZe-Guang HanYihong SunWenyi WeiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li-Yu Huang Junjie Zhao Hao Chen Lixin Wan Hiroyuki Inuzuka Jianping Guo Xuhong Fu Yangyang Zhai Zhaoning Lu Xuefei Wang Ze-Guang Han Yihong Sun Wenyi Wei SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis
description	Upstream pathways regulating Brg1 stability and their role in carcinogenesis are unknown. Here they show Brg1 to be phosphorylated by CK1δ to promote its ubiquitination by SCFFBW7 (FBW7), Brg1 stabilization to promote gastric cancer metastasis, and suggest targeting Brg1 in FBW7 compromised gastric cancer.
format	article
author	Li-Yu Huang Junjie Zhao Hao Chen Lixin Wan Hiroyuki Inuzuka Jianping Guo Xuhong Fu Yangyang Zhai Zhaoning Lu Xuefei Wang Ze-Guang Han Yihong Sun Wenyi Wei
author_facet	Li-Yu Huang Junjie Zhao Hao Chen Lixin Wan Hiroyuki Inuzuka Jianping Guo Xuhong Fu Yangyang Zhai Zhaoning Lu Xuefei Wang Ze-Guang Han Yihong Sun Wenyi Wei
author_sort	Li-Yu Huang
title	SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis
title_short	SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis
title_full	SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis
title_fullStr	SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis
title_full_unstemmed	SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis
title_sort	scffbw7-mediated degradation of brg1 suppresses gastric cancer metastasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/84dbbd4c59c645519a4588dd6fbb6578
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SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis

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