SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis

SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis

Upstream pathways regulating Brg1 stability and their role in carcinogenesis are unknown. Here they show Brg1 to be phosphorylated by CK1δ to promote its ubiquitination by SCFFBW7 (FBW7), Brg1 stabilization to promote gastric cancer metastasis, and suggest targeting Brg1 in FBW7 compromised gastric...

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Autores principales: Li-Yu Huang, Junjie Zhao, Hao Chen, Lixin Wan, Hiroyuki Inuzuka, Jianping Guo, Xuhong Fu, Yangyang Zhai, Zhaoning Lu, Xuefei Wang, Ze-Guang Han, Yihong Sun, Wenyi Wei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/84dbbd4c59c645519a4588dd6fbb6578
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