Blink index as a response predictor of blepharospasm to botulinum neurotoxin‐A treatment

Abstract Purpose We investigated the blink profiles and blink index using ocular surface interferometer in the patients with blepharospasm (BSP) and identified points to consider predictive factor after BSP treatment. Methods In total, 117 eyelids of 59 elderly patients and 20 eyelids of 10 age‐matc...

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Autores principales:	Jeongkyeong Jang, Helen Lew
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	blepharospasm blink index blink profile botulinum neurotoxin‐A Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/84dc897faf4e468088e4775be537caa9
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spelling	oai:doaj.org-article:84dc897faf4e468088e4775be537caa92021-11-25T06:06:36ZBlink index as a response predictor of blepharospasm to botulinum neurotoxin‐A treatment2162-327910.1002/brb3.2374https://doaj.org/article/84dc897faf4e468088e4775be537caa92021-11-01T00:00:00Zhttps://doi.org/10.1002/brb3.2374https://doaj.org/toc/2162-3279Abstract Purpose We investigated the blink profiles and blink index using ocular surface interferometer in the patients with blepharospasm (BSP) and identified points to consider predictive factor after BSP treatment. Methods In total, 117 eyelids of 59 elderly patients and 20 eyelids of 10 age‐matched control group were studied. All BSP patients applied botulinum toxin‐A (BoNT‐A) injection for treatment of BSP. An ocular surface interferometer (LipiView; TearScience, Morrisville, NC, USA) was used to measure blink profile and blink index; total and incomplete blinks/20 s, and the partial blink ratio (PBR). Eyelid blink time (including lid closing time, closure time, lid opening time), interblink times (IBT), closing speeds (OS), and opening speeds (OS) were analyzed using 600 blinks recorded over 20 s. Results Total blink rate was significantly higher in BSP patients compared to the age‐matched control group (p = .029) but other time‐related and speed‐related index including interpalpebral fissure, PBR, blink time, closure time (CT), interblink time, CS, and OS were not significantly different. In the responder of BSP patients, the average age was higher, CT was shorter, CS was faster than nonresponder (age; p = .016, CT; p < .001, CS; p = .042). Conclusion The blink index by analyzing the blink profile using ocular surface interferometer, and this blink index may be used as a predictive factor for evaluating the clinical response after BoNT‐A injection in blepharospasm patients.Jeongkyeong JangHelen LewWileyarticleblepharospasmblink indexblink profilebotulinum neurotoxin‐ANeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain and Behavior, Vol 11, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blepharospasm blink index blink profile botulinum neurotoxin‐A Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	blepharospasm blink index blink profile botulinum neurotoxin‐A Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jeongkyeong Jang Helen Lew Blink index as a response predictor of blepharospasm to botulinum neurotoxin‐A treatment
description	Abstract Purpose We investigated the blink profiles and blink index using ocular surface interferometer in the patients with blepharospasm (BSP) and identified points to consider predictive factor after BSP treatment. Methods In total, 117 eyelids of 59 elderly patients and 20 eyelids of 10 age‐matched control group were studied. All BSP patients applied botulinum toxin‐A (BoNT‐A) injection for treatment of BSP. An ocular surface interferometer (LipiView; TearScience, Morrisville, NC, USA) was used to measure blink profile and blink index; total and incomplete blinks/20 s, and the partial blink ratio (PBR). Eyelid blink time (including lid closing time, closure time, lid opening time), interblink times (IBT), closing speeds (OS), and opening speeds (OS) were analyzed using 600 blinks recorded over 20 s. Results Total blink rate was significantly higher in BSP patients compared to the age‐matched control group (p = .029) but other time‐related and speed‐related index including interpalpebral fissure, PBR, blink time, closure time (CT), interblink time, CS, and OS were not significantly different. In the responder of BSP patients, the average age was higher, CT was shorter, CS was faster than nonresponder (age; p = .016, CT; p < .001, CS; p = .042). Conclusion The blink index by analyzing the blink profile using ocular surface interferometer, and this blink index may be used as a predictive factor for evaluating the clinical response after BoNT‐A injection in blepharospasm patients.
format	article
author	Jeongkyeong Jang Helen Lew
author_facet	Jeongkyeong Jang Helen Lew
author_sort	Jeongkyeong Jang
title	Blink index as a response predictor of blepharospasm to botulinum neurotoxin‐A treatment
title_short	Blink index as a response predictor of blepharospasm to botulinum neurotoxin‐A treatment
title_full	Blink index as a response predictor of blepharospasm to botulinum neurotoxin‐A treatment
title_fullStr	Blink index as a response predictor of blepharospasm to botulinum neurotoxin‐A treatment
title_full_unstemmed	Blink index as a response predictor of blepharospasm to botulinum neurotoxin‐A treatment
title_sort	blink index as a response predictor of blepharospasm to botulinum neurotoxin‐a treatment
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/84dc897faf4e468088e4775be537caa9
work_keys_str_mv	AT jeongkyeongjang blinkindexasaresponsepredictorofblepharospasmtobotulinumneurotoxinatreatment AT helenlew blinkindexasaresponsepredictorofblepharospasmtobotulinumneurotoxinatreatment
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Blink index as a response predictor of blepharospasm to botulinum neurotoxin‐A treatment

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