Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives

Heart failure with preserved ejection fraction (HFpEF) is increasing in incidence and has a higher prevalence compared with heart failure with reduced ejection fraction. So far, no effective treatment of HFpEF is available, due to its complex underlying pathophysiology and clinical heterogeneity. Th...

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Autores principales:	Sebastian Rosch, Karl-Philipp Rommel, Markus Scholz, Holger Thiele, Philipp Lurz
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2020
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/84de4d52b6064609b3a63dd99348b445
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spelling	oai:doaj.org-article:84de4d52b6064609b3a63dd99348b4452021-12-04T16:03:35ZTranscriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives10.15420/cfr.2019.192057-75592057-7540https://doaj.org/article/84de4d52b6064609b3a63dd99348b4452020-09-01T00:00:00Zhttps://www.cfrjournal.com/articles/transcriptomic-research-in-heart-failure-with-preservedhttps://doaj.org/toc/2057-7540https://doaj.org/toc/2057-7559Heart failure with preserved ejection fraction (HFpEF) is increasing in incidence and has a higher prevalence compared with heart failure with reduced ejection fraction. So far, no effective treatment of HFpEF is available, due to its complex underlying pathophysiology and clinical heterogeneity. This article aims to provide an overview and a future perspective of transcriptomic biomarker research in HFpEF. Detailed characterisation of the HFpEF phenotype and its underlying molecular pathomechanisms may open new perspectives regarding early diagnosis, improved prognostication, new therapeutic targets and tailored therapies accounting for patient heterogeneity, which may improve quality of life. A combination of cross-sectional and longitudinal study designs with sufficiently large sample sizes are required to support this concept.Sebastian RoschKarl-Philipp RommelMarkus ScholzHolger ThielePhilipp LurzRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENCardiac Failure Review , Vol 6, Iss , Pp - (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Sebastian Rosch Karl-Philipp Rommel Markus Scholz Holger Thiele Philipp Lurz Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives
description	Heart failure with preserved ejection fraction (HFpEF) is increasing in incidence and has a higher prevalence compared with heart failure with reduced ejection fraction. So far, no effective treatment of HFpEF is available, due to its complex underlying pathophysiology and clinical heterogeneity. This article aims to provide an overview and a future perspective of transcriptomic biomarker research in HFpEF. Detailed characterisation of the HFpEF phenotype and its underlying molecular pathomechanisms may open new perspectives regarding early diagnosis, improved prognostication, new therapeutic targets and tailored therapies accounting for patient heterogeneity, which may improve quality of life. A combination of cross-sectional and longitudinal study designs with sufficiently large sample sizes are required to support this concept.
format	article
author	Sebastian Rosch Karl-Philipp Rommel Markus Scholz Holger Thiele Philipp Lurz
author_facet	Sebastian Rosch Karl-Philipp Rommel Markus Scholz Holger Thiele Philipp Lurz
author_sort	Sebastian Rosch
title	Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives
title_short	Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives
title_full	Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives
title_fullStr	Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives
title_full_unstemmed	Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives
title_sort	transcriptomic research in heart failure with preserved ejection fraction: current state and future perspectives
publisher	Radcliffe Medical Media
publishDate	2020
url	https://doaj.org/article/84de4d52b6064609b3a63dd99348b445
work_keys_str_mv	AT sebastianrosch transcriptomicresearchinheartfailurewithpreservedejectionfractioncurrentstateandfutureperspectives AT karlphilipprommel transcriptomicresearchinheartfailurewithpreservedejectionfractioncurrentstateandfutureperspectives AT markusscholz transcriptomicresearchinheartfailurewithpreservedejectionfractioncurrentstateandfutureperspectives AT holgerthiele transcriptomicresearchinheartfailurewithpreservedejectionfractioncurrentstateandfutureperspectives AT philipplurz transcriptomicresearchinheartfailurewithpreservedejectionfractioncurrentstateandfutureperspectives
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Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives

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