Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study

Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study

Abstract To evaluate the effect of cryoprecipitate (CRYO) transfusion in women referred for postpartum hemorrhage (PPH). This retrospective cohort study included patients with primary PPH referred to Gifu University Hospital between April 2013 and March 2020. We analyzed the effect of CRYO transfusi...

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Autores principales: Ryo Kamidani, Takahito Miyake, Hideshi Okada, Genki Yoshimura, Keigo Kusuzawa, Tomotaka Miura, Ryuichi Shimaoka, Hideaki Oiwa, Fuminori Yamaji, Yosuke Mizuno, Ryu Yasuda, Yuichiro Kitagawa, Tetsuya Fukuta, Takuma Ishihara, Tomomi Shiga, Haruka Okamoto, Masahito Tachi, Masato Shiba, Norihide Kanda, Sho Nachi, Tomoaki Doi, Takahiro Yoshida, Shozo Yoshida, Kenichiro Morishige, Shinji Ogura
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/84de643b2aac4da58f55180c1883857f
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Sumario:Abstract To evaluate the effect of cryoprecipitate (CRYO) transfusion in women referred for postpartum hemorrhage (PPH). This retrospective cohort study included patients with primary PPH referred to Gifu University Hospital between April 2013 and March 2020. We analyzed the effect of CRYO transfusion on fluid balance 24 h after the initial examination using a multivariable linear regression model adjusted for several confounding variables. To evaluate whether outcomes were modified by active bleeding, an interaction term of CRYO*active bleeding was incorporated into the multivariable model. We identified 157 women: 38 in the CRYO group (cases) and 119 in the control group. Fluid balance in the aforementioned period tended to decrease in the CRYO group compared with that in the control group (coefficient − 398.91; 95% CI − 1298.08 to + 500.26; p = 0.382). Active bleeding on contrast-enhanced computed tomography affected the relationship between CRYO transfusion and fluid balance (p = 0.016). Other outcomes, except for the overall transfusion requirement, were not significantly different; however, the interaction effect of active bleeding was significant (p = 0.016). CRYO transfusion may decrease the fluid balance in the first 24 h in PPH patients, especially in those without active bleeding.

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