Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study

Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study

Abstract To evaluate the effect of cryoprecipitate (CRYO) transfusion in women referred for postpartum hemorrhage (PPH). This retrospective cohort study included patients with primary PPH referred to Gifu University Hospital between April 2013 and March 2020. We analyzed the effect of CRYO transfusi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ryo Kamidani, Takahito Miyake, Hideshi Okada, Genki Yoshimura, Keigo Kusuzawa, Tomotaka Miura, Ryuichi Shimaoka, Hideaki Oiwa, Fuminori Yamaji, Yosuke Mizuno, Ryu Yasuda, Yuichiro Kitagawa, Tetsuya Fukuta, Takuma Ishihara, Tomomi Shiga, Haruka Okamoto, Masahito Tachi, Masato Shiba, Norihide Kanda, Sho Nachi, Tomoaki Doi, Takahiro Yoshida, Shozo Yoshida, Kenichiro Morishige, Shinji Ogura
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/84de643b2aac4da58f55180c1883857f
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:84de643b2aac4da58f55180c1883857f
record_format dspace
spelling oai:doaj.org-article:84de643b2aac4da58f55180c1883857f2021-12-02T18:50:03ZEffect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study10.1038/s41598-021-97954-52045-2322https://doaj.org/article/84de643b2aac4da58f55180c1883857f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97954-5https://doaj.org/toc/2045-2322Abstract To evaluate the effect of cryoprecipitate (CRYO) transfusion in women referred for postpartum hemorrhage (PPH). This retrospective cohort study included patients with primary PPH referred to Gifu University Hospital between April 2013 and March 2020. We analyzed the effect of CRYO transfusion on fluid balance 24 h after the initial examination using a multivariable linear regression model adjusted for several confounding variables. To evaluate whether outcomes were modified by active bleeding, an interaction term of CRYO*active bleeding was incorporated into the multivariable model. We identified 157 women: 38 in the CRYO group (cases) and 119 in the control group. Fluid balance in the aforementioned period tended to decrease in the CRYO group compared with that in the control group (coefficient − 398.91; 95% CI − 1298.08 to + 500.26; p = 0.382). Active bleeding on contrast-enhanced computed tomography affected the relationship between CRYO transfusion and fluid balance (p = 0.016). Other outcomes, except for the overall transfusion requirement, were not significantly different; however, the interaction effect of active bleeding was significant (p = 0.016). CRYO transfusion may decrease the fluid balance in the first 24 h in PPH patients, especially in those without active bleeding.Ryo KamidaniTakahito MiyakeHideshi OkadaGenki YoshimuraKeigo KusuzawaTomotaka MiuraRyuichi ShimaokaHideaki OiwaFuminori YamajiYosuke MizunoRyu YasudaYuichiro KitagawaTetsuya FukutaTakuma IshiharaTomomi ShigaHaruka OkamotoMasahito TachiMasato ShibaNorihide KandaSho NachiTomoaki DoiTakahiro YoshidaShozo YoshidaKenichiro MorishigeShinji OguraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ryo Kamidani
Takahito Miyake
Hideshi Okada
Genki Yoshimura
Keigo Kusuzawa
Tomotaka Miura
Ryuichi Shimaoka
Hideaki Oiwa
Fuminori Yamaji
Yosuke Mizuno
Ryu Yasuda
Yuichiro Kitagawa
Tetsuya Fukuta
Takuma Ishihara
Tomomi Shiga
Haruka Okamoto
Masahito Tachi
Masato Shiba
Norihide Kanda
Sho Nachi
Tomoaki Doi
Takahiro Yoshida
Shozo Yoshida
Kenichiro Morishige
Shinji Ogura
Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study
description Abstract To evaluate the effect of cryoprecipitate (CRYO) transfusion in women referred for postpartum hemorrhage (PPH). This retrospective cohort study included patients with primary PPH referred to Gifu University Hospital between April 2013 and March 2020. We analyzed the effect of CRYO transfusion on fluid balance 24 h after the initial examination using a multivariable linear regression model adjusted for several confounding variables. To evaluate whether outcomes were modified by active bleeding, an interaction term of CRYO*active bleeding was incorporated into the multivariable model. We identified 157 women: 38 in the CRYO group (cases) and 119 in the control group. Fluid balance in the aforementioned period tended to decrease in the CRYO group compared with that in the control group (coefficient − 398.91; 95% CI − 1298.08 to + 500.26; p = 0.382). Active bleeding on contrast-enhanced computed tomography affected the relationship between CRYO transfusion and fluid balance (p = 0.016). Other outcomes, except for the overall transfusion requirement, were not significantly different; however, the interaction effect of active bleeding was significant (p = 0.016). CRYO transfusion may decrease the fluid balance in the first 24 h in PPH patients, especially in those without active bleeding.
format article
author Ryo Kamidani
Takahito Miyake
Hideshi Okada
Genki Yoshimura
Keigo Kusuzawa
Tomotaka Miura
Ryuichi Shimaoka
Hideaki Oiwa
Fuminori Yamaji
Yosuke Mizuno
Ryu Yasuda
Yuichiro Kitagawa
Tetsuya Fukuta
Takuma Ishihara
Tomomi Shiga
Haruka Okamoto
Masahito Tachi
Masato Shiba
Norihide Kanda
Sho Nachi
Tomoaki Doi
Takahiro Yoshida
Shozo Yoshida
Kenichiro Morishige
Shinji Ogura
author_facet Ryo Kamidani
Takahito Miyake
Hideshi Okada
Genki Yoshimura
Keigo Kusuzawa
Tomotaka Miura
Ryuichi Shimaoka
Hideaki Oiwa
Fuminori Yamaji
Yosuke Mizuno
Ryu Yasuda
Yuichiro Kitagawa
Tetsuya Fukuta
Takuma Ishihara
Tomomi Shiga
Haruka Okamoto
Masahito Tachi
Masato Shiba
Norihide Kanda
Sho Nachi
Tomoaki Doi
Takahiro Yoshida
Shozo Yoshida
Kenichiro Morishige
Shinji Ogura
author_sort Ryo Kamidani
title Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study
title_short Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study
title_full Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study
title_fullStr Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study
title_full_unstemmed Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study
title_sort effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/84de643b2aac4da58f55180c1883857f
work_keys_str_mv AT ryokamidani effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT takahitomiyake effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT hideshiokada effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT genkiyoshimura effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT keigokusuzawa effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT tomotakamiura effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT ryuichishimaoka effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT hideakioiwa effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT fuminoriyamaji effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT yosukemizuno effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT ryuyasuda effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT yuichirokitagawa effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT tetsuyafukuta effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT takumaishihara effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT tomomishiga effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT harukaokamoto effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT masahitotachi effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT masatoshiba effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT norihidekanda effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT shonachi effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT tomoakidoi effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT takahiroyoshida effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT shozoyoshida effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT kenichiromorishige effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
AT shinjiogura effectofcryoprecipitatetransfusiontherapyinpatientswithpostpartumhemorrhagearetrospectivecohortstudy
_version_ 1718377515680006144

Ejemplares similares