Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study

Bernhard T Baune,1– 3 Ioana Florea,4 Bjarke Ebert,5 Maëlys Touya,6 Anders Ettrup,5 Monica Hadi,7 Hongye Ren8 1Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany; 2Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia;...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Baune BT, Florea I, Ebert B, Touya M, Ettrup A, Hadi M, Ren H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	antidepressant therapy major depressive disorder onset of treatment effect patient experience symptoms quality of life Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/84dedaa58b0f4ca2bbbeb8b081acea9b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:84dedaa58b0f4ca2bbbeb8b081acea9b
record_format	dspace
spelling	oai:doaj.org-article:84dedaa58b0f4ca2bbbeb8b081acea9b2021-12-02T18:47:16ZPatient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study1178-2021https://doaj.org/article/84dedaa58b0f4ca2bbbeb8b081acea9b2021-09-01T00:00:00Zhttps://www.dovepress.com/patient-expectations-and-experiences-of-antidepressant-therapy-for-maj-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Bernhard T Baune,1– 3 Ioana Florea,4 Bjarke Ebert,5 Maëlys Touya,6 Anders Ettrup,5 Monica Hadi,7 Hongye Ren8 1Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany; 2Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia; 3The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia; 4Clinical Development, H. Lundbeck A/S, Valby, Denmark; 5Medical Strategy & Communication, H. Lundbeck A/S, Valby, Denmark; 6Value Evidence, Lundbeck, Deerfield, IL, USA; 7Patient-Centered Research, Evidera, London, UK; 8Value Evidence, H. Lundbeck A/S, Valby, DenmarkCorrespondence: Hongye Ren Email HNRE@lundbeck.comPurpose: This qualitative study explored patient perceptions of the most burdensome symptoms of major depressive disorder (MDD), the impact of symptoms on patients’ daily lives, and patient expectations and experiences regarding the timing of onset of antidepressant pharmacotherapy.Patients and Methods: Data were collected through facilitated, patient focus-group sessions in the USA between May and June 2019. Participants were adults with confirmed MDD who reported a major depressive episode within the past 2 years, for which they had received pharmacologic treatment for ≥ 6 weeks. The semi-structured discussion focused on the key topics of bothersome symptoms of MDD, the impact of symptoms on quality of life, and the effects of antidepressant treatment. Interviews were audio-recorded; findings were summarized using a content-analysis approach.Results: Five focus-group sessions were undertaken, involving a total of 29 patients (each attended one session; mean age, 43.4 years; 72.4% female). Mean time since confirmed diagnosis of MDD was 13.1 years. The most commonly prescribed antidepressants received were bupropion (41.4% of participants), escitalopram (34.5%), and sertraline (34.5%). The most frequently reported bothersome MDD symptoms were fatigue (mentioned by 58.6% of participants), lack of motivation/loss of interest (51.7%), anxiety/panic (44.8%), sadness (41.4%), and lack of concentration/brain fog (41.4%). Socialization, family life, and work were the areas in which quality of life was most impacted. Participants expressed dissatisfaction with their antidepressant treatment. Fast symptom resolution was mentioned as a priority (defined as < 1 week by 38.5% of participants and ≤ 1 month by 65.4%). Most participants had not experienced fast relief from their symptoms with current or previous antidepressant medications.Conclusion: Results of this qualitative study suggest that fatigue, anhedonia, cognitive symptoms, and anxiety are some of the most bothersome symptoms for patients with MDD and highlight the importance of obtaining rapid relief from these symptoms in order to improve outcomes and patient satisfaction with antidepressant medication.Keywords: antidepressant therapy, major depressive disorder, onset of treatment effect, patient experience, symptoms, quality of lifeBaune BTFlorea IEbert BTouya MEttrup AHadi MRen HDove Medical Pressarticleantidepressant therapymajor depressive disorderonset of treatment effectpatient experiencesymptomsquality of lifeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2995-3006 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antidepressant therapy major depressive disorder onset of treatment effect patient experience symptoms quality of life Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	antidepressant therapy major depressive disorder onset of treatment effect patient experience symptoms quality of life Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Baune BT Florea I Ebert B Touya M Ettrup A Hadi M Ren H Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study
description	Bernhard T Baune,1– 3 Ioana Florea,4 Bjarke Ebert,5 Maëlys Touya,6 Anders Ettrup,5 Monica Hadi,7 Hongye Ren8 1Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany; 2Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia; 3The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia; 4Clinical Development, H. Lundbeck A/S, Valby, Denmark; 5Medical Strategy & Communication, H. Lundbeck A/S, Valby, Denmark; 6Value Evidence, Lundbeck, Deerfield, IL, USA; 7Patient-Centered Research, Evidera, London, UK; 8Value Evidence, H. Lundbeck A/S, Valby, DenmarkCorrespondence: Hongye Ren Email HNRE@lundbeck.comPurpose: This qualitative study explored patient perceptions of the most burdensome symptoms of major depressive disorder (MDD), the impact of symptoms on patients’ daily lives, and patient expectations and experiences regarding the timing of onset of antidepressant pharmacotherapy.Patients and Methods: Data were collected through facilitated, patient focus-group sessions in the USA between May and June 2019. Participants were adults with confirmed MDD who reported a major depressive episode within the past 2 years, for which they had received pharmacologic treatment for ≥ 6 weeks. The semi-structured discussion focused on the key topics of bothersome symptoms of MDD, the impact of symptoms on quality of life, and the effects of antidepressant treatment. Interviews were audio-recorded; findings were summarized using a content-analysis approach.Results: Five focus-group sessions were undertaken, involving a total of 29 patients (each attended one session; mean age, 43.4 years; 72.4% female). Mean time since confirmed diagnosis of MDD was 13.1 years. The most commonly prescribed antidepressants received were bupropion (41.4% of participants), escitalopram (34.5%), and sertraline (34.5%). The most frequently reported bothersome MDD symptoms were fatigue (mentioned by 58.6% of participants), lack of motivation/loss of interest (51.7%), anxiety/panic (44.8%), sadness (41.4%), and lack of concentration/brain fog (41.4%). Socialization, family life, and work were the areas in which quality of life was most impacted. Participants expressed dissatisfaction with their antidepressant treatment. Fast symptom resolution was mentioned as a priority (defined as < 1 week by 38.5% of participants and ≤ 1 month by 65.4%). Most participants had not experienced fast relief from their symptoms with current or previous antidepressant medications.Conclusion: Results of this qualitative study suggest that fatigue, anhedonia, cognitive symptoms, and anxiety are some of the most bothersome symptoms for patients with MDD and highlight the importance of obtaining rapid relief from these symptoms in order to improve outcomes and patient satisfaction with antidepressant medication.Keywords: antidepressant therapy, major depressive disorder, onset of treatment effect, patient experience, symptoms, quality of life
format	article
author	Baune BT Florea I Ebert B Touya M Ettrup A Hadi M Ren H
author_facet	Baune BT Florea I Ebert B Touya M Ettrup A Hadi M Ren H
author_sort	Baune BT
title	Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study
title_short	Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study
title_full	Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study
title_fullStr	Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study
title_full_unstemmed	Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study
title_sort	patient expectations and experiences of antidepressant therapy for major depressive disorder: a qualitative study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/84dedaa58b0f4ca2bbbeb8b081acea9b
work_keys_str_mv	AT baunebt patientexpectationsandexperiencesofantidepressanttherapyformajordepressivedisorderaqualitativestudy AT floreai patientexpectationsandexperiencesofantidepressanttherapyformajordepressivedisorderaqualitativestudy AT ebertb patientexpectationsandexperiencesofantidepressanttherapyformajordepressivedisorderaqualitativestudy AT touyam patientexpectationsandexperiencesofantidepressanttherapyformajordepressivedisorderaqualitativestudy AT ettrupa patientexpectationsandexperiencesofantidepressanttherapyformajordepressivedisorderaqualitativestudy AT hadim patientexpectationsandexperiencesofantidepressanttherapyformajordepressivedisorderaqualitativestudy AT renh patientexpectationsandexperiencesofantidepressanttherapyformajordepressivedisorderaqualitativestudy
_version_	1718377634950283264

Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study

Ejemplares similares