Relationship Between Fibroblast Growth Factor 19 and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus

Jin Ook Chung,1 Seon-Young Park,2 Dong Hyeok Cho,1 Dong Jin Chung,1 Min Young Chung1 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, 501-757, Republic of Korea; 2Division of Gastroenterology and Hepatology, Department o...

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Autores principales:	Chung JO, Park SY, Cho DH, Chung DJ, Chung MY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetic retinopathy fibroblast growth factor 19 type 2 diabetes mellitus Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/84e4c76bb79b4db7be3a1b7abbc1e6dd
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spelling	oai:doaj.org-article:84e4c76bb79b4db7be3a1b7abbc1e6dd2021-12-02T19:17:36ZRelationship Between Fibroblast Growth Factor 19 and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus1178-7007https://doaj.org/article/84e4c76bb79b4db7be3a1b7abbc1e6dd2021-12-01T00:00:00Zhttps://www.dovepress.com/relationship-between-fibroblast-growth-factor-19-and-diabetic-retinopa-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Jin Ook Chung,1 Seon-Young Park,2 Dong Hyeok Cho,1 Dong Jin Chung,1 Min Young Chung1 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, 501-757, Republic of Korea; 2Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, 501-757, Republic of KoreaCorrespondence: Jin Ook Chung; Min Young ChungDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju, 501-757, Republic of KoreaTel +82-62-220-6296; +82-62-220-6297Fax +82-62-225-8578Email imagine-jjo@hanmail.net; jrjjo222@gmail.comAim: This study aimed to evaluate whether fibroblast growth factor 19 (FGF19) is associated with the risk of diabetic retinopathy in patients with type 2 diabetes mellitus (T2DM).Methods: A total of 357 patients with T2DM were investigated in this cross-sectional study. Logistic regression analysis was performed to assess the association between FGF19 level and diabetic retinopathy.Results: Serum FGF19 level was significantly lower in patients with diabetic retinopathy in those without diabetic retinopathy. The multivariable analysis revealed a significant association between serum FGF19 level and diabetic retinopathy (odds ratio for every 1 standard deviation increase in logarithmic value = 0.69, 95% confidence interval 0.51– 0.94, p = 0.019).Conclusion: Serum FGF19 level was negatively associated with diabetic retinopathy in patients with T2DM.Keywords: diabetic retinopathy, fibroblast growth factor 19, type 2 diabetes mellitusChung JOPark SYCho DHChung DJChung MYDove Medical Pressarticlediabetic retinopathyfibroblast growth factor 19type 2 diabetes mellitusSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4715-4721 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic retinopathy fibroblast growth factor 19 type 2 diabetes mellitus Specialties of internal medicine RC581-951
spellingShingle	diabetic retinopathy fibroblast growth factor 19 type 2 diabetes mellitus Specialties of internal medicine RC581-951 Chung JO Park SY Cho DH Chung DJ Chung MY Relationship Between Fibroblast Growth Factor 19 and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus
description	Jin Ook Chung,1 Seon-Young Park,2 Dong Hyeok Cho,1 Dong Jin Chung,1 Min Young Chung1 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, 501-757, Republic of Korea; 2Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, 501-757, Republic of KoreaCorrespondence: Jin Ook Chung; Min Young ChungDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju, 501-757, Republic of KoreaTel +82-62-220-6296; +82-62-220-6297Fax +82-62-225-8578Email imagine-jjo@hanmail.net; jrjjo222@gmail.comAim: This study aimed to evaluate whether fibroblast growth factor 19 (FGF19) is associated with the risk of diabetic retinopathy in patients with type 2 diabetes mellitus (T2DM).Methods: A total of 357 patients with T2DM were investigated in this cross-sectional study. Logistic regression analysis was performed to assess the association between FGF19 level and diabetic retinopathy.Results: Serum FGF19 level was significantly lower in patients with diabetic retinopathy in those without diabetic retinopathy. The multivariable analysis revealed a significant association between serum FGF19 level and diabetic retinopathy (odds ratio for every 1 standard deviation increase in logarithmic value = 0.69, 95% confidence interval 0.51– 0.94, p = 0.019).Conclusion: Serum FGF19 level was negatively associated with diabetic retinopathy in patients with T2DM.Keywords: diabetic retinopathy, fibroblast growth factor 19, type 2 diabetes mellitus
format	article
author	Chung JO Park SY Cho DH Chung DJ Chung MY
author_facet	Chung JO Park SY Cho DH Chung DJ Chung MY
author_sort	Chung JO
title	Relationship Between Fibroblast Growth Factor 19 and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus
title_short	Relationship Between Fibroblast Growth Factor 19 and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus
title_full	Relationship Between Fibroblast Growth Factor 19 and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus
title_fullStr	Relationship Between Fibroblast Growth Factor 19 and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus
title_full_unstemmed	Relationship Between Fibroblast Growth Factor 19 and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus
title_sort	relationship between fibroblast growth factor 19 and diabetic retinopathy in patients with type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/84e4c76bb79b4db7be3a1b7abbc1e6dd
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_version_	1718376862746411008

Relationship Between Fibroblast Growth Factor 19 and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus

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