Edematous severe acute malnutrition is characterized by hypomethylation of DNA
The edematous form of severe acute childhood malnutrition (ESAM) presents with more severe multi-organ dysfunction than non-edematous SAM (NESAM). Here the authors assess genome-wide DNA methylation in buccal cells of SAM children and find that ESAM is characterized by hypomethylation at genes assoc...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/84e6b256abe147388cbba5a420607002 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:84e6b256abe147388cbba5a420607002 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:84e6b256abe147388cbba5a4206070022021-12-02T15:35:27ZEdematous severe acute malnutrition is characterized by hypomethylation of DNA10.1038/s41467-019-13433-62041-1723https://doaj.org/article/84e6b256abe147388cbba5a4206070022019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13433-6https://doaj.org/toc/2041-1723The edematous form of severe acute childhood malnutrition (ESAM) presents with more severe multi-organ dysfunction than non-edematous SAM (NESAM). Here the authors assess genome-wide DNA methylation in buccal cells of SAM children and find that ESAM is characterized by hypomethylation at genes associated with disorders of nutrition and metabolism, including fatty liver and diabetes.Katharina V. SchulzeShanker SwaminathanSharon HowellAarti JajooNatasha C. LieOrgen BrownRoa SadatNancy HallLiang ZhaoKwesi MarshallThaddaeus MayMarvin E. ReidCarolyn Taylor-BryanXueqing WangJohn W. BelmontYongtao GuanMark J. ManaryIndi TrehanColin A. McKenzieNeil A. HanchardNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Katharina V. Schulze Shanker Swaminathan Sharon Howell Aarti Jajoo Natasha C. Lie Orgen Brown Roa Sadat Nancy Hall Liang Zhao Kwesi Marshall Thaddaeus May Marvin E. Reid Carolyn Taylor-Bryan Xueqing Wang John W. Belmont Yongtao Guan Mark J. Manary Indi Trehan Colin A. McKenzie Neil A. Hanchard Edematous severe acute malnutrition is characterized by hypomethylation of DNA |
| description |
The edematous form of severe acute childhood malnutrition (ESAM) presents with more severe multi-organ dysfunction than non-edematous SAM (NESAM). Here the authors assess genome-wide DNA methylation in buccal cells of SAM children and find that ESAM is characterized by hypomethylation at genes associated with disorders of nutrition and metabolism, including fatty liver and diabetes. |
| format |
article |
| author |
Katharina V. Schulze Shanker Swaminathan Sharon Howell Aarti Jajoo Natasha C. Lie Orgen Brown Roa Sadat Nancy Hall Liang Zhao Kwesi Marshall Thaddaeus May Marvin E. Reid Carolyn Taylor-Bryan Xueqing Wang John W. Belmont Yongtao Guan Mark J. Manary Indi Trehan Colin A. McKenzie Neil A. Hanchard |
| author_facet |
Katharina V. Schulze Shanker Swaminathan Sharon Howell Aarti Jajoo Natasha C. Lie Orgen Brown Roa Sadat Nancy Hall Liang Zhao Kwesi Marshall Thaddaeus May Marvin E. Reid Carolyn Taylor-Bryan Xueqing Wang John W. Belmont Yongtao Guan Mark J. Manary Indi Trehan Colin A. McKenzie Neil A. Hanchard |
| author_sort |
Katharina V. Schulze |
| title |
Edematous severe acute malnutrition is characterized by hypomethylation of DNA |
| title_short |
Edematous severe acute malnutrition is characterized by hypomethylation of DNA |
| title_full |
Edematous severe acute malnutrition is characterized by hypomethylation of DNA |
| title_fullStr |
Edematous severe acute malnutrition is characterized by hypomethylation of DNA |
| title_full_unstemmed |
Edematous severe acute malnutrition is characterized by hypomethylation of DNA |
| title_sort |
edematous severe acute malnutrition is characterized by hypomethylation of dna |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/84e6b256abe147388cbba5a420607002 |
| work_keys_str_mv |
AT katharinavschulze edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT shankerswaminathan edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT sharonhowell edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT aartijajoo edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT natashaclie edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT orgenbrown edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT roasadat edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT nancyhall edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT liangzhao edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT kwesimarshall edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT thaddaeusmay edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT marvinereid edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT carolyntaylorbryan edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT xueqingwang edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT johnwbelmont edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT yongtaoguan edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT markjmanary edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT inditrehan edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT colinamckenzie edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna AT neilahanchard edematoussevereacutemalnutritionischaracterizedbyhypomethylationofdna |
| _version_ |
1718386544078749696 |