The MRI posterior drawer test to assess posterior cruciate ligament functionality and knee joint laxity

Abstract Clinical Magnetic Resonance Imaging (MRI) of joints is limited to mere morphologic evaluation and fails to directly visualize joint or ligament function. In this controlled laboratory study, we show that knee joint functionality may be quantified in situ and as a function of graded posterio...

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Autores principales:	Lena Marie Wollschläger, Karl Ludger Radke, Justus Schock, Niklas Kotowski, David Latz, Dominika Kanschik, Timm Joachim Filler, Svenja Caspers, Gerald Antoch, Joachim Windolf, Daniel Benjamin Abrar, Sven Nebelung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84ec21f4e20942189fa0c1080d2c81c1
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spelling	oai:doaj.org-article:84ec21f4e20942189fa0c1080d2c81c12021-12-02T18:07:52ZThe MRI posterior drawer test to assess posterior cruciate ligament functionality and knee joint laxity10.1038/s41598-021-99216-w2045-2322https://doaj.org/article/84ec21f4e20942189fa0c1080d2c81c12021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99216-whttps://doaj.org/toc/2045-2322Abstract Clinical Magnetic Resonance Imaging (MRI) of joints is limited to mere morphologic evaluation and fails to directly visualize joint or ligament function. In this controlled laboratory study, we show that knee joint functionality may be quantified in situ and as a function of graded posterior cruciate ligament (PCL)-deficiency by combining MRI and standardized loading. 11 human knee joints underwent MRI under standardized posterior loading in the unloaded and loaded (147 N) configurations and in the intact, partially, and completely PCL-injured conditions. For each specimen, configuration, and condition, 3D joint models were implemented to analyse joint kinematics based on 3D Euclidean vectors and their projections on the Cartesian planes. Manual 2D measurements served as reference. With increasing PCL deficiency, vector projections increased significantly in the anteroposterior dimension under loading and manual measurements demonstrated similar patterns of change. Consequently, if combined with advanced image post-processing, stress MRI is a powerful diagnostic adjunct to evaluate ligament functionality and joint laxity in multiple dimensions and may have a role in differentiating PCL injury patterns, therapeutic decision-making, and treatment monitoring.Lena Marie WollschlägerKarl Ludger RadkeJustus SchockNiklas KotowskiDavid LatzDominika KanschikTimm Joachim FillerSvenja CaspersGerald AntochJoachim WindolfDaniel Benjamin AbrarSven NebelungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lena Marie Wollschläger Karl Ludger Radke Justus Schock Niklas Kotowski David Latz Dominika Kanschik Timm Joachim Filler Svenja Caspers Gerald Antoch Joachim Windolf Daniel Benjamin Abrar Sven Nebelung The MRI posterior drawer test to assess posterior cruciate ligament functionality and knee joint laxity
description	Abstract Clinical Magnetic Resonance Imaging (MRI) of joints is limited to mere morphologic evaluation and fails to directly visualize joint or ligament function. In this controlled laboratory study, we show that knee joint functionality may be quantified in situ and as a function of graded posterior cruciate ligament (PCL)-deficiency by combining MRI and standardized loading. 11 human knee joints underwent MRI under standardized posterior loading in the unloaded and loaded (147 N) configurations and in the intact, partially, and completely PCL-injured conditions. For each specimen, configuration, and condition, 3D joint models were implemented to analyse joint kinematics based on 3D Euclidean vectors and their projections on the Cartesian planes. Manual 2D measurements served as reference. With increasing PCL deficiency, vector projections increased significantly in the anteroposterior dimension under loading and manual measurements demonstrated similar patterns of change. Consequently, if combined with advanced image post-processing, stress MRI is a powerful diagnostic adjunct to evaluate ligament functionality and joint laxity in multiple dimensions and may have a role in differentiating PCL injury patterns, therapeutic decision-making, and treatment monitoring.
format	article
author	Lena Marie Wollschläger Karl Ludger Radke Justus Schock Niklas Kotowski David Latz Dominika Kanschik Timm Joachim Filler Svenja Caspers Gerald Antoch Joachim Windolf Daniel Benjamin Abrar Sven Nebelung
author_facet	Lena Marie Wollschläger Karl Ludger Radke Justus Schock Niklas Kotowski David Latz Dominika Kanschik Timm Joachim Filler Svenja Caspers Gerald Antoch Joachim Windolf Daniel Benjamin Abrar Sven Nebelung
author_sort	Lena Marie Wollschläger
title	The MRI posterior drawer test to assess posterior cruciate ligament functionality and knee joint laxity
title_short	The MRI posterior drawer test to assess posterior cruciate ligament functionality and knee joint laxity
title_full	The MRI posterior drawer test to assess posterior cruciate ligament functionality and knee joint laxity
title_fullStr	The MRI posterior drawer test to assess posterior cruciate ligament functionality and knee joint laxity
title_full_unstemmed	The MRI posterior drawer test to assess posterior cruciate ligament functionality and knee joint laxity
title_sort	mri posterior drawer test to assess posterior cruciate ligament functionality and knee joint laxity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/84ec21f4e20942189fa0c1080d2c81c1
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The MRI posterior drawer test to assess posterior cruciate ligament functionality and knee joint laxity

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