Seroprevalence of Yellow fever, Chikungunya, and Zika virus at a community level in the Gambella Region, South West Ethiopia.

Yellow fever (YF), Chikungunya (CHIK), and Zika(ZIK) are among re-emerging arboviral diseases of major public health concern. Despite the proximity of the Gambella Region to South Sudan where arboviral cases have been recorded repeatedly the current epidemiological situation is unclear in this part...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Getahun Asebe, Daniela Michlmayr, Gezahegne Mamo, Woldaregay Erku Abegaz, Adugna Endale, Girmay Medhin, James W Larrick, Mengistu Legesse
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/84ec5ddecf5a403e9c82791aaa6d25fc
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:84ec5ddecf5a403e9c82791aaa6d25fc
record_format dspace
spelling oai:doaj.org-article:84ec5ddecf5a403e9c82791aaa6d25fc2021-12-02T20:09:36ZSeroprevalence of Yellow fever, Chikungunya, and Zika virus at a community level in the Gambella Region, South West Ethiopia.1932-620310.1371/journal.pone.0253953https://doaj.org/article/84ec5ddecf5a403e9c82791aaa6d25fc2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253953https://doaj.org/toc/1932-6203Yellow fever (YF), Chikungunya (CHIK), and Zika(ZIK) are among re-emerging arboviral diseases of major public health concern. Despite the proximity of the Gambella Region to South Sudan where arboviral cases have been recorded repeatedly the current epidemiological situation is unclear in this part of southwest Ethiopia. Therefore, we conducted a community-based seroprevalence survey of YF virus (YFV), CHIK virus (CHIKV), and ZIK virus (ZIKV) infections in two selected districts. A cross-sectional study was conducted in two locations of the Gambella region (Lare and Itang) to investigate the seroprevalence of these viruses' infections. Blood samples were collected from the study participants and screened for IgG antibodies specific to YFV and CHIKV infections using enzyme-linked immunosorbent assays (ELISA). For the detection of ZIKV specific IgG antibodies, Blockade-of-binding ELISA was used. Data were analyzed using the STATA version 13.1 Softwares. A total of 150 individuals (96 males and 54 females, age ranging from 18 to 65 years, mean age ± SD = 35.92 ± 10.99) participated and provided blood samples. Among the 150 samples 135, 90, and 150 were screened for YFV, CHIKV, and ZIKV, respectively. Hence, 2.9% (95% CI: 1.1-7.7%), 15.6% (95% CI: 9.3-24.8%), and 27.3% (95% CI: 20.7-35.3%) of samples tested positive for IgG antibodies to YFV, CHIKV, and ZIKV infections, respectively. Among the individual seropositive for ZIKV, YFV and CHIKV, only six, one and three had a history of residence outside the Gambella region respectively. Agro-pastoral occupation was significantly associated with a higher prevalence of IgG against CHIKV (AOR = 14.17; 95%CI: 2.30, 87.30) and residency in the Lare district (AOR = 11; 95%CI: 3.31, 39.81) was found to be significantly associated with a higher prevalence of IgG against ZIKV. Our findings revealed the occurrence of YFV, CHIKV and ZIKV infections in the study locations.Getahun AsebeDaniela MichlmayrGezahegne MamoWoldaregay Erku AbegazAdugna EndaleGirmay MedhinJames W LarrickMengistu LegessePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253953 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Getahun Asebe
Daniela Michlmayr
Gezahegne Mamo
Woldaregay Erku Abegaz
Adugna Endale
Girmay Medhin
James W Larrick
Mengistu Legesse
Seroprevalence of Yellow fever, Chikungunya, and Zika virus at a community level in the Gambella Region, South West Ethiopia.
description Yellow fever (YF), Chikungunya (CHIK), and Zika(ZIK) are among re-emerging arboviral diseases of major public health concern. Despite the proximity of the Gambella Region to South Sudan where arboviral cases have been recorded repeatedly the current epidemiological situation is unclear in this part of southwest Ethiopia. Therefore, we conducted a community-based seroprevalence survey of YF virus (YFV), CHIK virus (CHIKV), and ZIK virus (ZIKV) infections in two selected districts. A cross-sectional study was conducted in two locations of the Gambella region (Lare and Itang) to investigate the seroprevalence of these viruses' infections. Blood samples were collected from the study participants and screened for IgG antibodies specific to YFV and CHIKV infections using enzyme-linked immunosorbent assays (ELISA). For the detection of ZIKV specific IgG antibodies, Blockade-of-binding ELISA was used. Data were analyzed using the STATA version 13.1 Softwares. A total of 150 individuals (96 males and 54 females, age ranging from 18 to 65 years, mean age ± SD = 35.92 ± 10.99) participated and provided blood samples. Among the 150 samples 135, 90, and 150 were screened for YFV, CHIKV, and ZIKV, respectively. Hence, 2.9% (95% CI: 1.1-7.7%), 15.6% (95% CI: 9.3-24.8%), and 27.3% (95% CI: 20.7-35.3%) of samples tested positive for IgG antibodies to YFV, CHIKV, and ZIKV infections, respectively. Among the individual seropositive for ZIKV, YFV and CHIKV, only six, one and three had a history of residence outside the Gambella region respectively. Agro-pastoral occupation was significantly associated with a higher prevalence of IgG against CHIKV (AOR = 14.17; 95%CI: 2.30, 87.30) and residency in the Lare district (AOR = 11; 95%CI: 3.31, 39.81) was found to be significantly associated with a higher prevalence of IgG against ZIKV. Our findings revealed the occurrence of YFV, CHIKV and ZIKV infections in the study locations.
format article
author Getahun Asebe
Daniela Michlmayr
Gezahegne Mamo
Woldaregay Erku Abegaz
Adugna Endale
Girmay Medhin
James W Larrick
Mengistu Legesse
author_facet Getahun Asebe
Daniela Michlmayr
Gezahegne Mamo
Woldaregay Erku Abegaz
Adugna Endale
Girmay Medhin
James W Larrick
Mengistu Legesse
author_sort Getahun Asebe
title Seroprevalence of Yellow fever, Chikungunya, and Zika virus at a community level in the Gambella Region, South West Ethiopia.
title_short Seroprevalence of Yellow fever, Chikungunya, and Zika virus at a community level in the Gambella Region, South West Ethiopia.
title_full Seroprevalence of Yellow fever, Chikungunya, and Zika virus at a community level in the Gambella Region, South West Ethiopia.
title_fullStr Seroprevalence of Yellow fever, Chikungunya, and Zika virus at a community level in the Gambella Region, South West Ethiopia.
title_full_unstemmed Seroprevalence of Yellow fever, Chikungunya, and Zika virus at a community level in the Gambella Region, South West Ethiopia.
title_sort seroprevalence of yellow fever, chikungunya, and zika virus at a community level in the gambella region, south west ethiopia.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/84ec5ddecf5a403e9c82791aaa6d25fc
work_keys_str_mv AT getahunasebe seroprevalenceofyellowfeverchikungunyaandzikavirusatacommunitylevelinthegambellaregionsouthwestethiopia
AT danielamichlmayr seroprevalenceofyellowfeverchikungunyaandzikavirusatacommunitylevelinthegambellaregionsouthwestethiopia
AT gezahegnemamo seroprevalenceofyellowfeverchikungunyaandzikavirusatacommunitylevelinthegambellaregionsouthwestethiopia
AT woldaregayerkuabegaz seroprevalenceofyellowfeverchikungunyaandzikavirusatacommunitylevelinthegambellaregionsouthwestethiopia
AT adugnaendale seroprevalenceofyellowfeverchikungunyaandzikavirusatacommunitylevelinthegambellaregionsouthwestethiopia
AT girmaymedhin seroprevalenceofyellowfeverchikungunyaandzikavirusatacommunitylevelinthegambellaregionsouthwestethiopia
AT jameswlarrick seroprevalenceofyellowfeverchikungunyaandzikavirusatacommunitylevelinthegambellaregionsouthwestethiopia
AT mengistulegesse seroprevalenceofyellowfeverchikungunyaandzikavirusatacommunitylevelinthegambellaregionsouthwestethiopia
_version_ 1718375072102612992