Solid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin

Chao Li,1 Kaixiang Zhou,1 Dongmei Chen,1,2 Wei Xu,1 Yanfei Tao,1 Yuanhu Pan,2 Kuiyu Meng,2 Muhammad Abu Bakr Shabbir,2 Qianying Liu,1 Lingli Huang,2 Shuyu Xie1 1National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan H...

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Autores principales:	Li C, Zhou KX, Chen D, Xu W, Tao Y, Pan Y, Meng K, Shabbir MAB, Liu Q, Huang L, Xie S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Enrofloxacin Solid lipid nanoparticles (SLNs) Enteric coating Palatability Bioavailability Stability Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/84eeb301d6384370959df6e229e0cb8f
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spelling	oai:doaj.org-article:84eeb301d6384370959df6e229e0cb8f2021-12-02T09:05:49ZSolid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin1178-2013https://doaj.org/article/84eeb301d6384370959df6e229e0cb8f2019-03-01T00:00:00Zhttps://www.dovepress.com/solid-lipid-nanoparticles-with-enteric-coating-for-improving-stability-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chao Li,1 Kaixiang Zhou,1 Dongmei Chen,1,2 Wei Xu,1 Yanfei Tao,1 Yuanhu Pan,2 Kuiyu Meng,2 Muhammad Abu Bakr Shabbir,2 Qianying Liu,1 Lingli Huang,2 Shuyu Xie1 1National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan Hubei, China; 2MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, Wuhan Hubei, China Background: The poor palatability, variable oral bioavailability, stimulation to gastric mucosa, and light instability limited the application of enrofloxacin (ENR). The enteric granules combining solid lipid nanoparticles (SLNs) with enteric coating were explored to overcome these disadvantages. Materials and methods: ENR-loaded SLNs were produced by a hot homogenization and ultrasonic emulsification method and the enteric granules with SLNs as inner core were prepared by wet granulation followed by coating using polyacrylic resin II (PRII). The formulation was optimized by using orthogonal or single factor test screening. Results: The optimal SLNs with loading capacity (LC) and price as inspection indexes were consisted of 10 mL 3% polyvinyl alcohol per 0.8 g ENR and 2.4 g octadecanoic acid. The sizes, LC, polydispersion index, and zeta potential of the SLNs were 308.5±6.3 nm, 15.73%±0.31%, 0.352±0.015, and -22.3 mv, respectively. The best enteric granules were used 15% PRII as coating materials. The release of the enteric granules in simulated intestine fluid (SIF, pH=8) was significantly faster than in simulated gastric fluid (SGF, pH=2) and simultaneously slower than those of SLNs and native ENR. The granules showed good stability in influencing factor experiment. The granules displayed a similar daily feed intake as the control group and higher daily feed intake than ENR powder and single-coating granules. Compared to the ENR soluble powder, the area under the plasma concentration–time curve and mean retention time of the enteric granules after intragastric administration were increased from 4.26±0.85 µg h/mL and 6.80±2.28 hours to 11.24±3.33 µg h/mL and 17.97±4.01 hours, respectively. Conclusion: The enteric granules combination SLNs with enteric coating significantly improved the stability, palatability, sustained-release performance and oral bioavailability of ENR. The novel technology will be a potential measure to overcome the similar disadvantages of other drugs. Keywords: enrofloxacin, solid lipid nanoparticles, enteric coating, palatability, bioavailability, light stabilityLi CZhou KXChen DXu WTao YPan YMeng KShabbir MABLiu QHuang LXie SDove Medical PressarticleEnrofloxacinSolid lipid nanoparticles (SLNs)Enteric coatingPalatabilityBioavailabilityStabilityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 1619-1631 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Enrofloxacin Solid lipid nanoparticles (SLNs) Enteric coating Palatability Bioavailability Stability Medicine (General) R5-920
spellingShingle	Enrofloxacin Solid lipid nanoparticles (SLNs) Enteric coating Palatability Bioavailability Stability Medicine (General) R5-920 Li C Zhou KX Chen D Xu W Tao Y Pan Y Meng K Shabbir MAB Liu Q Huang L Xie S Solid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin
description	Chao Li,1 Kaixiang Zhou,1 Dongmei Chen,1,2 Wei Xu,1 Yanfei Tao,1 Yuanhu Pan,2 Kuiyu Meng,2 Muhammad Abu Bakr Shabbir,2 Qianying Liu,1 Lingli Huang,2 Shuyu Xie1 1National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan Hubei, China; 2MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, Wuhan Hubei, China Background: The poor palatability, variable oral bioavailability, stimulation to gastric mucosa, and light instability limited the application of enrofloxacin (ENR). The enteric granules combining solid lipid nanoparticles (SLNs) with enteric coating were explored to overcome these disadvantages. Materials and methods: ENR-loaded SLNs were produced by a hot homogenization and ultrasonic emulsification method and the enteric granules with SLNs as inner core were prepared by wet granulation followed by coating using polyacrylic resin II (PRII). The formulation was optimized by using orthogonal or single factor test screening. Results: The optimal SLNs with loading capacity (LC) and price as inspection indexes were consisted of 10 mL 3% polyvinyl alcohol per 0.8 g ENR and 2.4 g octadecanoic acid. The sizes, LC, polydispersion index, and zeta potential of the SLNs were 308.5±6.3 nm, 15.73%±0.31%, 0.352±0.015, and -22.3 mv, respectively. The best enteric granules were used 15% PRII as coating materials. The release of the enteric granules in simulated intestine fluid (SIF, pH=8) was significantly faster than in simulated gastric fluid (SGF, pH=2) and simultaneously slower than those of SLNs and native ENR. The granules showed good stability in influencing factor experiment. The granules displayed a similar daily feed intake as the control group and higher daily feed intake than ENR powder and single-coating granules. Compared to the ENR soluble powder, the area under the plasma concentration–time curve and mean retention time of the enteric granules after intragastric administration were increased from 4.26±0.85 µg h/mL and 6.80±2.28 hours to 11.24±3.33 µg h/mL and 17.97±4.01 hours, respectively. Conclusion: The enteric granules combination SLNs with enteric coating significantly improved the stability, palatability, sustained-release performance and oral bioavailability of ENR. The novel technology will be a potential measure to overcome the similar disadvantages of other drugs. Keywords: enrofloxacin, solid lipid nanoparticles, enteric coating, palatability, bioavailability, light stability
format	article
author	Li C Zhou KX Chen D Xu W Tao Y Pan Y Meng K Shabbir MAB Liu Q Huang L Xie S
author_facet	Li C Zhou KX Chen D Xu W Tao Y Pan Y Meng K Shabbir MAB Liu Q Huang L Xie S
author_sort	Li C
title	Solid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin
title_short	Solid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin
title_full	Solid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin
title_fullStr	Solid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin
title_full_unstemmed	Solid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin
title_sort	solid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/84eeb301d6384370959df6e229e0cb8f
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Solid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin

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